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Mahtab Moayeri Selected Research

anthrax toxin (anthrax lethal factor)

3/2015A heterodimer of a VHH (variable domains of camelid heavy chain-only) antibody that inhibits anthrax toxin cell binding linked to a VHH antibody that blocks oligomer formation is highly protective in an anthrax spore challenge model.
3/2013Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumors.
1/2013Anthrax edema factor toxicity is strongly mediated by the N-end rule.
1/2012Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages.
11/2011Mouse monoclonal antibodies to anthrax edema factor protect against infection.
11/2010Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice.
12/2009Cellular and systemic effects of anthrax lethal toxin and edema toxin.
7/2009Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo.
1/2008Role of N-terminal amino acids in the potency of anthrax lethal factor.
12/2005Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge.
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Mahtab Moayeri Research Topics

Disease

40Anthrax
10/2015 - 02/2002
13Edema
10/2015 - 11/2005
12Infection
09/2015 - 05/2003
4Shock
08/2010 - 04/2004
3Neoplasms (Cancer)
03/2013 - 01/2008
2Peritonitis
03/2015 - 01/2014
2Sepsis (Septicemia)
06/2007 - 02/2005
1Tuberculosis (Tuberculoses)
09/2015
1Pulmonary Tuberculosis
09/2015
1Gout
03/2015
1Toxoplasmosis
01/2014
1Inflammation
10/2012
1Necrosis
12/2009
1Melanoma (Melanoma, Malignant)
01/2008
1Anoxia (Hypoxia)
09/2003

Drug/Important Bio-Agent (IBA)

12AntigensIBA
10/2015 - 02/2005
12anthrax toxin (anthrax lethal factor)IBA
03/2015 - 02/2002
5Virulence Factors (Pathogenicity Factors)IBA
10/2015 - 12/2009
5edema factorIBA
10/2015 - 08/2009
4Adenylate Cyclase (Adenylyl Cyclase)IBA
01/2013 - 11/2005
3Caspase 1 (ICE Protease)IBA
01/2014 - 12/2008
3Monoclonal AntibodiesIBA
09/2013 - 03/2006
2Matrix MetalloproteinasesIBA
09/2015 - 01/2008
2Uric Acid (Urate)IBA
03/2015 - 01/2014
2FlagellinIBA
01/2014 - 10/2012
2InflammasomesIBA
01/2014 - 01/2014
2Proteins (Proteins, Gene)IBA
09/2013 - 07/2009
2Anti-Bacterial Agents (Antibiotics)IBA
09/2013 - 10/2005
2Calmodulin (Calcium-Dependent Activator Protein)IBA
01/2013 - 08/2009
2CA 074 methyl esterIBA
08/2010 - 10/2009
2Proteasome Endopeptidase Complex (Proteasome)IBA
12/2008 - 02/2008
2Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2008 - 01/2008
2Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
06/2004 - 05/2003
1PeptidesIBA
10/2015
1Heme Oxygenase-1IBA
09/2015
1Matrix Metalloproteinase 1 (Interstitial Collagenase)IBA
09/2015
115-deoxyprostaglandin J2IBA
03/2015
1AntibodiesIBA
03/2015
1sodium arseniteIBA
01/2014
1Arsenicals (Arsenic Compounds)IBA
01/2014
1arsenic trioxide (Trisenox)FDA Link
01/2014
1NigericinIBA
01/2014
1Leucine (L-Leucine)FDA Link
01/2014
1marenostrin (pyrin)IBA
01/2014
1Interleukin-18 (Interleukin 18)IBA
01/2014
1ExotoxinsIBA
09/2013
1Peptide Hydrolases (Proteases)IBA
03/2013
1Adenosine Monophosphate (AMP)IBA
01/2013
1Adenosine Triphosphate (ATP)IBA
01/2013
1ProstaglandinsIBA
10/2012
1LipidsIBA
10/2012
1Cyclooxygenase 1IBA
10/2012
1LeukotrienesIBA
10/2012
1EpitopesIBA
08/2011
1DobutamineFDA LinkGeneric
03/2011
1adefovirIBA
03/2011
1Auranofin (Ridaura)FDA Link
03/2011
1Cathepsin BIBA
08/2010
1Quinidine (Chinidin)FDA LinkGeneric
08/2010
1Interleukin-1 (Interleukin 1)IBA
01/2010
1Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
01/2010
1Cyclic AMP (AMP, Cyclic)IBA
08/2009
1von Willebrand FactorIBA
07/2009
1Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA
05/2009
1Norepinephrine (Noradrenaline)FDA LinkGeneric
04/2009
1Protein Kinases (Protein Kinase)IBA
12/2008
1Protein SIBA
12/2008
1betadex (beta-cyclodextrin)IBA
06/2008
1beta-CyclodextrinsIBA
06/2008
1anthrax toxin receptorsIBA
01/2008
1Cisplatin (Platino)FDA LinkGeneric
08/2006
1Pseudomonas aeruginosa toxA proteinIBA
08/2006
1periodate-oxidized adenosine 5'-triphosphateIBA
07/2006
1Diphtheria ToxinIBA
07/2006
12',3'-dialdehyde ATPIBA
07/2006
1Single-Chain AntibodiesIBA
03/2006
1Ketotifen (Ketotifene)FDA Link
02/2006
1Nitric Oxide (Nitrogen Monoxide)FDA Link
04/2004
1Bacterial ToxinsIBA
04/2004
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2003
1HormonesIBA
05/2003
1DNA (Deoxyribonucleic Acid)IBA
05/2003
1KinesinIBA
02/2002

Therapy/Procedure

2Therapeutics
03/2015 - 09/2013