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Yoshikuni Mizuno Selected Research

istradefylline

3/2015A long-term study of istradefylline safety and efficacy in patients with Parkinson disease.
7/2013Adenosine A2A receptor antagonist istradefylline reduces daily OFF time in Parkinson's disease.
7/2010Clinical efficacy of istradefylline (KW-6002) in Parkinson's disease: a randomized, controlled study.

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Yoshikuni Mizuno Research Topics

Disease

66Parkinson Disease (Parkinson's Disease)
09/2015 - 05/2002
14Parkinsonian Disorders (Parkinsonism)
11/2014 - 08/2002
11Dementia (Dementias)
06/2014 - 05/2002
5Neurodegenerative Diseases (Neurodegenerative Disease)
03/2006 - 12/2003
4Dyskinesias (Dyskinesia)
07/2013 - 06/2003
4Tauopathies
04/2012 - 01/2002
4Ischemia
03/2006 - 03/2002
4Stroke (Strokes)
02/2006 - 06/2002
3Nausea
06/2014 - 11/2010
3Alzheimer Disease (Alzheimer's Disease)
04/2008 - 02/2002
3Reperfusion Injury
03/2006 - 04/2004
3Infection
02/2005 - 04/2003
3Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
01/2005 - 08/2002
2Gaucher Disease (Gaucher's Disease)
05/2011 - 01/2007
2Disease Progression
08/2010 - 01/2003
2Myoclonus (Nocturnal Myoclonus)
06/2006 - 06/2003
2Infarction
02/2006 - 06/2002
2Cerebral Infarction
07/2004 - 06/2002
2Tremor (Tremors)
06/2003 - 04/2003
2Gliosis
06/2003 - 03/2003
1Multiple System Atrophy
12/2013
1Orthostatic Hypotension (Postural Hypotension)
08/2013
1Hallucinations (Hallucination)
08/2013
1Bipolar Disorder (Mania)
04/2012
1Constipation
11/2010
1Fatigue
11/2010
1Capgras Syndrome
01/2010
1Frontotemporal Lobar Degeneration (Semantic Dementia)
12/2008
1Genetic Predisposition to Disease (Genetic Predisposition)
06/2008
1Pain (Aches)
04/2007
1Spinocerebellar Degenerations (Marinesco Sjogren Syndrome)
04/2007
1Machado-Joseph Disease (Spinocerebellar Ataxia Type 3)
04/2007
1Neutropenia
11/2006
1Vitamin E Deficiency
09/2006
1Hypoparathyroidism
06/2006
1Hypocalcemia
06/2006
1Brain Ischemia (Cerebral Ischemia)
03/2006
1Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
03/2006
1Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome)
02/2006

Drug/Important Bio-Agent (IBA)

17Levodopa (L Dopa)FDA LinkGeneric
03/2015 - 04/2003
16alpha-SynucleinIBA
02/2009 - 05/2002
11UbiquitinIBA
08/2011 - 03/2003
9cytidylyl-(3'-5')-cytidine (CpC)IBA
01/2006 - 02/2002
7pramipexol (pramipexole)FDA LinkGeneric
01/2014 - 10/2003
61- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
08/2011 - 02/2004
5Phosphotransferases (Kinase)IBA
09/2015 - 02/2007
5Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
02/2006 - 08/2002
4Leucine (L-Leucine)FDA Link
09/2015 - 02/2007
4SynucleinsIBA
12/2013 - 04/2008
3DNA (Deoxyribonucleic Acid)IBA
03/2015 - 08/2002
3istradefyllineIBA
03/2015 - 07/2010
3N 0437FDA Link
12/2014 - 09/2013
3Dopamine (Intropin)FDA LinkGeneric
01/2010 - 11/2005
3Dopamine Agonists (Dopamine Agonist)IBA
10/2009 - 01/2006
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2008 - 05/2006
33-Iodobenzylguanidine (Iobenguane)IBA
08/2006 - 09/2004
3Proteins (Proteins, Gene)IBA
01/2005 - 08/2004
2ropinirole (Requip)FDA LinkGeneric
12/2014 - 10/2007
2Glutamic Acid (Glutamate)FDA Link
06/2014 - 07/2009
2Glucosylceramidase (Glucocerebrosidase)IBA
05/2011 - 01/2007
2Selegiline (E250)FDA LinkGeneric
01/2010 - 12/2002
2Granulocyte Colony-Stimulating Factor (G-CSF)IBA
11/2006 - 03/2006
2Proteasome Endopeptidase Complex (Proteasome)IBA
10/2006 - 11/2004
2enhanced green fluorescent proteinIBA
03/2006 - 04/2004
2Carbon MonoxideIBA
02/2005 - 01/2002
2Bromocriptine (Parlodel)FDA LinkGeneric
10/2003 - 04/2003
2Creatine Kinase (Creatine Phosphokinase)IBA
04/2003 - 04/2003
1donepezil (Aricept)FDA LinkGeneric
06/2014
1pamidronate (APD)FDA LinkGeneric
01/2014
1SpectrinIBA
12/2013
1calbindinIBA
12/2013
1CalpainIBA
12/2013
1Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA
12/2013
1Dopamine and cAMP-Regulated Phosphoprotein 32IBA
12/2013
1Adenosine A2A Receptor (Adenosine A2A Receptors)IBA
07/2013
1Glycogen Synthase (Synthase I)IBA
04/2012
1LithiumIBA
04/2012
1Lithium ChlorideIBA
04/2012
1Glycogen Synthase Kinase 3IBA
04/2012
1tensins (tensin)IBA
06/2009
1PTEN-induced putative kinaseIBA
06/2009
1glycogen synthase kinase 3 betaIBA
12/2008
1pigment epithelium-derived factorIBA
08/2007
1Nerve Growth Factors (Neurotrophins)IBA
08/2007
1Protein Phosphatase 2 (Protein Phosphatase 2A)IBA
04/2007
1tributyl phosphate (TBP)IBA
04/2007
1Adrenal Cortex Hormones (Corticosteroids)IBA
04/2007
1TATA-Box Binding Protein (TATA-Binding Protein)IBA
04/2007
1entacapone (Comtan)FDA Link
01/2007
1Dopa DecarboxylaseIBA
01/2007
1thymidine 5'-triphosphate (TTP)IBA
09/2006
1A-Form DNA (A-DNA)IBA
08/2006
1Mitochondrial DNA (mtDNA)IBA
08/2006
1polysialic acidIBA
05/2006
1Intravenous Immunoglobulins (IVIG)FDA Link
03/2006
1CytokinesIBA
03/2006
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
03/2006
1SteroidsIBA
03/2006

Therapy/Procedure

4Activities of Daily Living (ADL)
09/2013 - 10/2007
1Thyroidectomy
06/2006