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Takashi Miwa Selected Research

Properdin

8/2015Properdin Contributes to Allergic Airway Inflammation through Local C3a Generation.
10/2014Tissue-specific deletion of Crry from mouse proximal tubular epithelial cells increases susceptibility to renal ischemia-reperfusion injury.
4/2013Blocking properdin, the alternative pathway, and anaphylatoxin receptors ameliorates renal ischemia-reperfusion injury in decay-accelerating factor and CD59 double-knockout mice.
1/2013Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis.
10/2010Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury.
1/2008Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement.

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Takashi Miwa Research Topics

Disease

8Inflammation
08/2015 - 12/2006
3Kidney Diseases (Kidney Disease)
10/2014 - 01/2013
3Reperfusion Injury
10/2014 - 03/2004
2Asthma (Bronchial Asthma)
08/2015 - 02/2013
2Ischemia
10/2014 - 03/2004
2Hypertension (High Blood Pressure)
06/2014 - 03/2014
2Type 2 Diabetes Mellitus (MODY)
03/2014 - 06/2009
2Vascular System Injuries
02/2013 - 05/2009
2Autoimmune Diseases (Autoimmune Disease)
04/2007 - 09/2002
2Splenomegaly
04/2007 - 09/2002
2Dermatitis
04/2007 - 09/2002
2Lymphatic Diseases (Lymphadenopathy)
04/2007 - 09/2002
2Catalepsy
09/2004 - 07/2003
1Gastritis
03/2015
1Esophagitis
03/2015
1Peptic Ulcer (Peptic Ulcers)
03/2015
1Heart Injuries
06/2014
1Diabetic Nephropathies (Diabetic Nephropathy)
03/2014
1Diabetes Mellitus
03/2014
1Thrombocytopenia (Thrombopenia)
03/2013
1Endocarditis
02/2013
1Cardiovascular Diseases (Cardiovascular Disease)
02/2013
1Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II)
01/2013
1Glomerulonephritis
01/2013
1Cushing Syndrome
01/2012
1Rare Diseases (Rare Disease)
01/2012
1Hyperplasia
01/2012
1Hypercholesterolemia
01/2012
1Dementia (Dementias)
01/2011
1Alzheimer Disease (Alzheimer's Disease)
01/2011
1Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy)
01/2011
1Arthritis (Polyarthritis)
10/2010
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
07/2009
1Insulin Resistance
06/2009
1Atherosclerosis
05/2009
1Albuminuria
05/2009
1Lymphopenia (Lymphocytopenia)
03/2009
1Hypersensitivity (Allergy)
03/2009
1Meningococcal Infections
01/2008
1Hemolysis
01/2008
1Infection
09/2007
1Proteinuria
01/2007
1Nephritis
01/2007
1Schizophrenia (Dementia Praecox)
05/2005
1Neoplasms (Cancer)
02/2005
1Hypothyroidism
01/2005
1Congenital Abnormalities (Deformity)
09/2004
1Contracture
09/2004
1Rheumatic Diseases (Rheumatism)
07/2004
1Thrombosis (Thrombus)
03/2004
1Acute Kidney Injury (Acute Renal Failure)
03/2004
1Autoimmune Hemolytic Anemia (Cold Agglutinin Disease)
12/2002

Drug/Important Bio-Agent (IBA)

20Complement System Proteins (Complement)IBA
08/2015 - 05/2002
7CD55 Antigens (Decay Accelerating Factor)IBA
04/2013 - 09/2002
6ProperdinIBA
08/2015 - 01/2008
3aripiprazole (Abilify)FDA Link
05/2005 - 07/2003
2Urea (Carbamide)FDA LinkGeneric
03/2015 - 10/2014
2AnaphylatoxinsIBA
06/2014 - 04/2013
2Complement Membrane Attack Complex (Membrane Attack Complex)IBA
04/2013 - 03/2004
2ChromatinIBA
04/2007 - 09/2002
2CytokinesIBA
12/2006 - 07/2004
2Risperidone (Risperdal Consta)FDA LinkGeneric
09/2004 - 07/2003
1NitrogenIBA
10/2014
1Angiotensin IIIBA
06/2014
1Anaphylatoxin C5a ReceptorIBA
06/2014
1LDL CholesterolIBA
03/2014
1Triglycerides (Triacylglycerol)IBA
03/2014
1HDL CholesterolIBA
03/2014
1Hemoglobins (Hemoglobin)IBA
03/2014
1VancomycinFDA LinkGeneric
02/2013
1Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA
02/2013
1Complement Factor H (Factor H)IBA
01/2013
1Adrenocorticotropic Hormone (ACTH)FDA Link
01/2012
1Eicosapentaenoic AcidIBA
01/2012
1tranilast (N 5')IBA
01/2011
1Interleukin-23 (Interleukin 23)IBA
07/2009
1PPAR gammaIBA
06/2009
1pioglitazone (Actos)FDA Link
06/2009
1CholesterolIBA
05/2009
1Immunoglobulin G (IgG)IBA
05/2009
1Apolipoproteins E (ApoE)IBA
05/2009
1Nitroarginine (NG Nitro L Arginine)IBA
01/2005
1Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA
01/2005
1Adrenergic Receptors (Adrenergic Receptor)IBA
01/2005
1Methimazole (Thiamazole)FDA LinkGeneric
01/2005
1olanzapine (Zyprexa)FDA Link
09/2004
1Antipsychotic Agents (Antipsychotics)IBA
09/2004
1ApomorphineIBA
09/2004
1Interleukin-18 (Interleukin 18)IBA
07/2004
1Homovanillic AcidIBA
07/2003
1Haloperidol (Haldol)FDA LinkGeneric
07/2003
13,4-Dihydroxyphenylacetic AcidIBA
07/2003
1Dopamine (Intropin)FDA LinkGeneric
07/2003
1AntibodiesIBA
12/2002

Therapy/Procedure

1Transplantation (Transplant Recipients)
02/2013
1Adrenalectomy
01/2012
1Organ Transplantation
02/2005
1Activities of Daily Living (ADL)
09/2004
1Kidney Transplantation
03/2004
1Oral Administration
07/2003