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Marzia Malcangio Selected Research

cathepsin S

5/2014Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain.
6/2012Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen-induced arthritis model.
4/2012Microglial signalling mechanisms: Cathepsin S and Fractalkine.
11/2010Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor.
10/2008Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-cyanopyrimidines. Part 2.
9/2008Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain.
8/2007Role of the cysteine protease cathepsin S in neuropathic hyperalgesia.
6/2007Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain.

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Marzia Malcangio Research Topics

Disease

25Pain (Aches)
06/2015 - 12/2002
16Neuralgia (Stump Neuralgia)
06/2015 - 10/2002
16Hyperalgesia
06/2015 - 10/2002
6Inflammation
06/2015 - 10/2002
5Hypersensitivity (Allergy)
06/2015 - 05/2002
2Experimental Arthritis
06/2015 - 06/2012
2Neoplasms (Cancer)
05/2014 - 08/2008
1Migraine Disorders (Migraine)
01/2013
1Bone Neoplasms (Bone Cancer)
09/2010
1Neoplasm Metastasis (Metastasis)
09/2010
1Carcinoma (Carcinomatosis)
09/2010
1Multiple Sclerosis
10/2008
1Peripheral Nervous System Diseases (PNS Diseases)
08/2008
1Myelitis
11/2006
1Epilepsy (Aura)
10/2004
1Parkinson Disease (Parkinson's Disease)
10/2004
1Alzheimer Disease (Alzheimer's Disease)
10/2004
1Neurogenic Inflammation
05/2002

Drug/Important Bio-Agent (IBA)

8cathepsin SIBA
05/2014 - 06/2007
7Chemokine CX3CL1IBA
05/2014 - 05/2008
5Analgesics (Analgesic Drugs)IBA
05/2014 - 11/2004
5Brain-Derived Neurotrophic Factor (BDNF)IBA
10/2004 - 10/2002
4Cysteine Proteases (Cysteine Protease)IBA
04/2012 - 06/2007
3ZymosanIBA
06/2015 - 02/2007
3Adenosine Triphosphate (ATP)IBA
09/2013 - 09/2010
3ChemokinesIBA
01/2013 - 04/2009
3Phosphotransferases (Kinase)IBA
09/2010 - 12/2002
2Reactive Oxygen Species (Oxygen Radicals)IBA
05/2014 - 01/2009
2Vincristine (Oncovin)FDA LinkGeneric
05/2014 - 08/2008
2Neutralizing AntibodiesIBA
06/2012 - 06/2007
2V28 receptorIBA
06/2012 - 08/2010
2Purinergic P2X7 ReceptorsIBA
11/2010 - 01/2010
2Carbon MonoxideIBA
09/2010 - 11/2006
2Interleukin-1beta (Interleukin 1 beta)IBA
01/2010 - 11/2006
2gabapentin (Neurontin)FDA LinkGeneric
09/2009 - 11/2004
2Formaldehyde (Formol)FDA Link
08/2008 - 10/2002
2p38 Mitogen-Activated Protein KinasesIBA
06/2007 - 11/2006
1GTP-Binding Proteins (G-Protein)IBA
06/2015
1CollagenIBA
06/2015
1Calcitonin Gene-Related PeptideIBA
06/2015
1Antineoplastic Agents (Antineoplastics)IBA
05/2014
1Purinergic Receptors (Receptors, Purine)IBA
09/2013
1CalciumIBA
09/2013
1CytokinesIBA
01/2013
1MicroRNAs (MicroRNA)IBA
01/2013
1Biological Markers (Surrogate Marker)IBA
01/2013
1Macromolecular SubstancesIBA
01/2013
1Collagen Type II (Type II Collagen)IBA
06/2012
1Acetaminophen (Paracetamol)FDA LinkGeneric
05/2012
1Pain-FreeIBA
01/2012
1Sodium Channels (Sodium Channel)IBA
01/2012
1copolymer 1 (glatiramer acetate)FDA Link
05/2011
1Interleukin-10 (Interleukin 10)IBA
05/2011
1Interleukin-4 (Interleukin 4)IBA
05/2011
1TRPV1 receptorIBA
03/2011
1N- (3- methoxyphenyl)- 4- chlorocinnamanilideIBA
03/2011
1AnkyrinsIBA
03/2011
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
03/2011
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2011
15- (5- iodo- 2- isopropyl- 4- methoxyphenoxy)pyrimidine- 2,4- diamineIBA
09/2010
12',3'-dialdehyde ATPIBA
01/2010
1Messenger RNA (mRNA)IBA
05/2009
1CatalaseIBA
01/2009
1Superoxide DismutaseIBA
01/2009
1CarrageenanIBA
01/2009
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
01/2009
1CholesterolIBA
08/2008
1Streptozocin (Streptozotocin)FDA Link
08/2008
1oxime cholest-4-en-3-oneIBA
08/2008
12- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA
04/2008
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
04/2008
1Liposomes (Liposome)IBA
08/2007
1Clodronic Acid (Clodronate)IBA
08/2007
1Protein Kinases (Protein Kinase)IBA
06/2007
1fluorocitrateIBA
02/2007
1Interleukin-1 Receptors (Interleukin 1 Receptor)IBA
11/2006
1Caspase 1 (ICE Protease)IBA
11/2006
1Morphine (MS Contin)FDA LinkGeneric
11/2004
1Iodoacetates (Iodoacetate)IBA
11/2004
1Octreotide (Sandostatin)FDA LinkGeneric
02/2003
1Neurotransmitter Agents (Neurotransmitter)IBA
12/2002
1Nerve Growth Factor (NGF)IBA
10/2002
1Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
05/2002
1Substance PIBA
05/2002

Therapy/Procedure

5Spinal Injections
01/2010 - 05/2002
3Oral Administration
09/2009 - 08/2008
2Ligation
06/2015 - 08/2010
2Drug Therapy (Chemotherapy)
05/2014 - 08/2008
2Injections
01/2010 - 11/2006
1Analgesia
01/2013
1Intra-Articular Injections
03/2011
1Intravenous Injections
08/2007