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Margaret R MacLean Selected Research

5-HT1B Serotonin Receptor

1/2017Serotonin Signaling Through the 5-HT1B Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension.
2/2010In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension.
8/2005Interdependent serotonin transporter and receptor pathways regulate S100A4/Mts1, a gene associated with pulmonary vascular disease.

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Margaret R MacLean Research Topics

Disease

28Pulmonary Arterial Hypertension
06/2021 - 03/2006
27Pulmonary Hypertension
11/2020 - 02/2002
16Hypoxia (Hypoxemia)
04/2020 - 12/2002
10Vascular Remodeling
12/2020 - 05/2004
8Right Ventricular Hypertrophy
06/2021 - 02/2002
3Familial Primary Pulmonary Hypertension
01/2021 - 01/2007
3Left Ventricular Dysfunction
05/2006 - 02/2002
2Vascular Diseases (Vascular Disease)
01/2021 - 08/2005
2Neoplasms (Cancer)
01/2021 - 03/2012
2Obesity
01/2021 - 07/2020
2Fibrosis (Cirrhosis)
10/2020 - 01/2013
2Inflammation (Inflammations)
07/2020 - 03/2012
2Vascular System Injuries
01/2017 - 03/2012
1Hypertension (High Blood Pressure)
01/2021
1Liver Diseases (Liver Disease)
01/2021
1Hypertrophy
10/2020
1Carcinoma (Carcinomatosis)
06/2020
1Heart Diseases (Heart Disease)
03/2012

Drug/Important Bio-Agent (IBA)

15Serotonin (5 Hydroxytryptamine)IBA
01/2021 - 05/2004
12Estrogens (Estrogen)FDA Link
01/2021 - 08/2012
10MicroRNAs (MicroRNA)IBA
01/2021 - 04/2010
6Proteins (Proteins, Gene)FDA Link
12/2020 - 12/2002
6Semaxinib (SU5416)IBA
04/2020 - 01/2013
6Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA
01/2017 - 08/2005
4Type II Bone Morphogenetic Protein Receptors (Bone Morphogenetic Protein Receptor Type II)IBA
01/2021 - 03/2006
4Aromatase (CYP19)IBA
01/2021 - 08/2014
3Serotonin ReceptorsIBA
06/2020 - 05/2005
3Estradiol (Delestrogen)FDA LinkGeneric
01/2020 - 05/2011
3Reactive Oxygen Species (Oxygen Radicals)IBA
01/2019 - 01/2016
3Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
01/2019 - 08/2012
35-HT1B Serotonin ReceptorIBA
01/2017 - 08/2005
3Messenger RNA (mRNA)IBA
05/2004 - 12/2002
2salicylhydroxamic acid (SHAM)IBA
10/2020 - 02/2002
2LeptinIBA
07/2020 - 01/2019
2Mitogen-Activated Protein KinasesIBA
04/2020 - 04/2003
2Anastrozole (Arimidex)FDA LinkGeneric
01/2019 - 01/2016
2Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA
06/2015 - 03/2006
2Dexfenfluramine (Redux)IBA
07/2013 - 06/2008
2EnzymesIBA
07/2013 - 08/2012
2Tryptophan HydroxylaseIBA
01/2013 - 01/2007
2Endothelin-1 (Endothelin 1)IBA
07/2006 - 02/2002
2Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
07/2006 - 12/2002
2Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
04/2003 - 12/2002
1Brain Natriuretic Peptide (Natrecor)FDA Link
06/2021
1Methamphetamine (Desoxyn)FDA LinkGeneric
06/2021
1Cytochrome P450 Family 19IBA
01/2021
1Hormones (Hormone)IBA
01/2021
1Gonadal Steroid Hormones (Sex Hormones)IBA
01/2021
1MelatoninIBA
11/2020
1Collagen Type I (Type I Collagen)IBA
10/2020
1Natriuretic PeptidesIBA
10/2020
1Atrial Natriuretic Factor (ANF)IBA
10/2020
1SteroidsIBA
07/2020
1AdiponectinIBA
07/2020
1MAP Kinase Kinase Kinase 5IBA
04/2020
1CytokinesIBA
04/2020
1Fulvestrant (Faslodex)FDA Link
11/2019
1Therapeutic UsesIBA
01/2019
12,2',4,6'-tetramethoxystilbeneIBA
01/2019
12-MethoxyestradiolIBA
01/2019
1Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA
01/2018
1Cytochrome P-450 CYP1A1 (CYP1A1)IBA
01/2018
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2018
1NADPH Oxidase 1IBA
01/2017
1AntioxidantsIBA
01/2017
1NADPH Oxidases (NAD(P)H oxidase)IBA
01/2017
1Oxidoreductases (Dehydrogenase)IBA
01/2016
1AMP-Activated Protein KinasesIBA
01/2016
1NADP (NADPH)IBA
01/2016
1Metformin (Glucophage)FDA LinkGeneric
01/2016
1Transforming Growth Factors (Transforming Growth Factor)IBA
10/2015
1Estrogen ReceptorsIBA
10/2015
1hexachlorocyclohexane x-factorIBA
10/2015
1hydralazine 4-anisaldehyde hydrazoneIBA
03/2015
1Caspase 3 (Caspase-3)IBA
07/2014
1Imatinib Mesylate (Gleevec)FDA Link
01/2013
1CollagenIBA
01/2013
1AntagomirsIBA
07/2012
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
04/2010
1MonocrotalineIBA
04/2010
1CitalopramFDA LinkGeneric
02/2010
1LY 393558IBA
02/2010
1p38 Mitogen-Activated Protein KinasesIBA
06/2008
1AminorexIBA
06/2008
1Protein Isoforms (Isoforms)IBA
07/2006
1Indomethacin (Indometacin)FDA LinkGeneric
07/2006
1Adenylyl Cyclases (Adenylyl Cyclase)IBA
07/2006
1MitogensIBA
07/2006
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
07/2006
1Cyclooxygenase InhibitorsIBA
07/2006
1U 0126 (UO 126)IBA
07/2006
1Type 4 Cyclic Nucleotide PhosphodiesterasesIBA
07/2006
1Phospholipases (Phospholipase)IBA
07/2006
1Prostaglandins EIBA
07/2006
1urotensin IIIBA
05/2006

Therapy/Procedure

2Therapeutics
12/2020 - 06/2020
2Ovariectomy (Oophorectomy)
03/2015 - 05/2011
2Ligation
05/2006 - 02/2002
1Subcutaneous Injections
04/2020
1Stents
03/2012