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Mary G Leonard Selected Research

IRL 1620

8/2013Endothelin B receptor agonist, IRL-1620, enhances angiogenesis and neurogenesis following cerebral ischemia in rats.
6/2012Endothelin B receptor agonist, IRL-1620, provides long-term neuroprotection in cerebral ischemia in rats.
10/2011Endothelin B receptor agonist, IRL-1620, reduces neurological damage following permanent middle cerebral artery occlusion in rats.
11/2009Repeated administration of ET(B) receptor agonist, IRL-1620, produces tachyphylaxis only to its hypotensive effect.

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Mary G Leonard Research Topics

Disease

3Brain Ischemia (Cerebral Ischemia)
08/2013 - 10/2011
3Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
08/2013 - 10/2011
1Brain Edema (Cerebral Edema)
06/2012
1Stroke (Strokes)
10/2011
1Hypotension (Low Blood Pressure)
11/2009
1Carcinoma (Carcinomatosis)
11/2009

Drug/Important Bio-Agent (IBA)

4IRL 1620IBA
08/2013 - 11/2009
3Endothelin B ReceptorIBA
08/2013 - 10/2011
2Endothelin-1 (Endothelin 1)IBA
08/2013 - 10/2011
1STF 62247IBA
08/2013
1Endothelin Receptors (Endothelin Receptor)IBA
06/2012
1Endothelin A ReceptorIBA
06/2012
1Endothelins (Endothelin)IBA
10/2011

Therapy/Procedure

1Intravenous Injections
08/2013