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Amy S Lee Selected Research

glucose-regulated proteins

8/2014Targeted deletion of ER chaperone GRP94 in the liver results in injury, repopulation of GRP94-positive hepatocytes, and spontaneous hepatocellular carcinoma development in aged mice.
4/2014Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential.
3/2014Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis.
12/2010Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis.
1/2010Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling.
7/2006Glucose regulated proteins in cancer progression, drug resistance and immunotherapy.
12/2002Cancer-inducible transgene expression by the Grp94 promoter: spontaneous activation in tumors of various origins and cancer-associated macrophages.

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Amy S Lee Research Topics

Disease

23Neoplasms (Cancer)
03/2015 - 03/2002
6Breast Neoplasms (Breast Cancer)
07/2011 - 07/2005
5Starvation
07/2011 - 12/2002
3Neoplasm Metastasis (Metastasis)
12/2013 - 07/2005
3Anoxia (Hypoxia)
07/2005 - 03/2002
2Fibrosis (Cirrhosis)
08/2014 - 07/2011
2Hepatocellular Carcinoma (Hepatoma)
08/2014 - 03/2014
2Endometrial Neoplasms (Endometrial Cancer)
07/2013 - 03/2013
2Prostatic Neoplasms (Prostate Cancer)
10/2007 - 10/2006
2Acidosis
07/2005 - 06/2004
1Inflammation
04/2014
1Cholangiocarcinoma
03/2014
1Liver Neoplasms (Liver Cancer)
03/2014
1Leukemia
12/2013
1Osteoarthritis
04/2012
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2012
1B-Cell Lymphoma (Lymphoma, B Cell)
07/2011
1Liver Diseases (Liver Disease)
07/2011
1Fatty Liver
07/2011
1Pancreatitis
12/2010
1Mucormycosis
06/2010
1Diabetic Ketoacidosis (Ketoacidosis, Diabetic)
06/2010
1Autoimmune Diseases (Autoimmune Disease)
01/2010
1Obesity
01/2010
1Insulin Resistance
01/2010
1Shock
05/2009
1Fever (Fevers)
02/2008
1Hypoglycemia (Reactive Hypoglycemia)
01/2008
1Glioma (Gliomas)
10/2007
1Glioblastoma (Glioblastoma Multiforme)
10/2007
1Residual Neoplasm
10/2007
1Carcinoma (Carcinomatosis)
06/2004
1Adenocarcinoma
03/2002

Drug/Important Bio-Agent (IBA)

12Glucose (Dextrose)FDA LinkGeneric
03/2015 - 12/2002
7glucose-regulated proteinsIBA
08/2014 - 12/2002
4Small Interfering RNA (siRNA)IBA
10/2007 - 07/2005
3Estrogens (Estrogen)FDA Link
07/2011 - 06/2004
3Nuclear Proteins (Protein, Nuclear)IBA
07/2011 - 05/2006
3Doxorubicin (Adriamycin)FDA LinkGeneric
02/2011 - 08/2006
2ParaffinIBA
02/2011 - 10/2007
21-phenyl-3,3-dimethyltriazene (PDT)IBA
06/2004 - 03/2002
2Ganciclovir (Cytovene)FDA LinkGeneric
06/2004 - 03/2002
1Heat-Shock Proteins (Heat-Shock Protein)IBA
04/2014
1tensins (tensin)IBA
03/2014
1Transcription Factor CHOPIBA
03/2013
1phosphoinositide-3,4,5-triphosphateIBA
01/2013
1CytokinesIBA
04/2012
1ThapsigarginIBA
04/2012
1Cytarabine (Cytosar-U)FDA LinkGeneric
01/2012
1Growth Differentiation Factor 15IBA
07/2011
1EnzymesIBA
07/2011
1Carrier Proteins (Binding Protein)IBA
07/2011
1major urinary proteinsIBA
07/2011
1Cysteine (L-Cysteine)FDA Link
07/2011
1Epidermal Growth Factor (EGF)IBA
07/2011
1Formaldehyde (Formol)FDA Link
02/2011
1taxaneIBA
02/2011
1CalreticulinIBA
12/2010
1CalnexinIBA
12/2010
1Caerulein (Ceruletide)IBA
12/2010
1IronIBA
06/2010
1Cell Surface ReceptorsIBA
09/2009
1Histone Deacetylases (Histone Deacetylase)IBA
05/2009
1Histone Deacetylase InhibitorsIBA
05/2009
1Transferrin Receptors (Transferrin Receptor)IBA
02/2008
1pyrvinium (Vankin)FDA Link
01/2008
1Adenosine Triphosphate (ATP)IBA
10/2007
1Fluorouracil (Carac)FDA LinkGeneric
10/2007
1temozolomide (Temodar)FDA LinkGeneric
10/2007
1epigallocatechin gallate (epigallocatechin-3-gallate)IBA
10/2007
1irinotecan (Camptosar)FDA LinkGeneric
10/2007
1Caspase 7IBA
10/2007
1HormonesIBA
10/2007
1Prostate-Specific Antigen (Semenogelase)IBA
10/2006
1Biological Markers (Surrogate Marker)IBA
08/2006
1glucose-regulated protein 170IBA
07/2006
1Sp1 Transcription FactorIBA
05/2006
1Insulin ReceptorIBA
05/2006
1Transcription Factors (Transcription Factor)IBA
05/2006
1DNA (Deoxyribonucleic Acid)IBA
05/2006
1OxygenIBA
07/2005
1Etoposide (VP 16)FDA LinkGeneric
07/2005
1combretastatinIBA
07/2005
1contortrostatinIBA
07/2005
1beta-Galactosidase (Lactaid)IBA
12/2002
1Messenger RNA (mRNA)IBA
12/2002
1Singlet OxygenIBA
03/2002
1Thymidine KinaseIBA
03/2002

Therapy/Procedure

5Drug Therapy (Chemotherapy)
02/2011 - 12/2002
4Heterologous Transplantation (Xenotransplantation)
12/2013 - 06/2004
2Photochemotherapy (Photodynamic Therapy)
06/2004 - 03/2002
1Adjuvant Chemotherapy
02/2011
1Prostatectomy (Retropubic Prostatectomy)
10/2007
1Castration
10/2006
1Immunotherapy
07/2006