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Macus Tien Kuo Selected Research

Argininosuccinate Synthase (Argininosuccinate Synthetase)

3/2015Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin.
1/2015Arginine deprivation in cancer therapy.
5/2012Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells.
8/2010Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes.
12/2009Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1alpha/Sp4.

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Macus Tien Kuo Research Topics

Disease

18Neoplasms (Cancer)
03/2015 - 03/2002
5Melanoma (Melanoma, Malignant)
03/2015 - 12/2009
3Ovarian Neoplasms (Ovarian Cancer)
06/2014 - 11/2012
2Starvation
01/2015 - 08/2010
2Hepatocellular Carcinoma (Hepatoma)
08/2010 - 03/2002
2Small Cell Lung Carcinoma (Small Cell Lung Cancer)
09/2008 - 07/2003
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
02/2012
1Breast Neoplasms (Breast Cancer)
01/2009
1Lung Neoplasms (Lung Cancer)
12/2004

Drug/Important Bio-Agent (IBA)

9PlatinumIBA
01/2015 - 03/2007
7Arginine (L-Arginine)FDA Link
03/2015 - 12/2009
7CopperIBA
06/2014 - 12/2004
6Cisplatin (Platino)FDA LinkGeneric
03/2015 - 07/2003
5Argininosuccinate Synthase (Argininosuccinate Synthetase)IBA
03/2015 - 12/2009
4ADI PEG20IBA
03/2015 - 08/2010
4arginine deiminaseIBA
11/2013 - 12/2009
3Carboplatin (JM8)FDA LinkGeneric
06/2014 - 06/2012
3Trientine (Trien)FDA Link
06/2014 - 06/2012
3Antineoplastic Agents (Antineoplastics)IBA
01/2014 - 11/2012
2ArginaseIBA
01/2015 - 08/2010
2copper transporter 1IBA
06/2014 - 02/2012
2EnzymesIBA
11/2013 - 08/2010
1Glucose (Dextrose)FDA LinkGeneric
11/2013
1Glutamine (L-Glutamine)FDA Link
11/2013
1ParaffinIBA
02/2012
1CitrullineIBA
08/2010
1Glutathione (Reduced Glutathione)IBA
01/2010
1Membrane Proteins (Integral Membrane Proteins)IBA
01/2009
1Adenosine Triphosphate (ATP)IBA
01/2009
1CadmiumIBA
09/2008
1Glutamate-Cysteine LigaseIBA
09/2008
1Complementary DNA (cDNA)IBA
07/2003
1Zidovudine (Retrovir)FDA LinkGeneric
07/2003
1P-GlycoproteinIBA
03/2002
1NADPH Oxidase (NAD(P)H oxidase)IBA
03/2002
12-Acetylaminofluorene (2 Acetylaminofluorene)IBA
03/2002

Therapy/Procedure

13Drug Therapy (Chemotherapy)
01/2015 - 07/2003