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Isao Kubota Selected Research

Diacylglycerol Kinase

1/2014Diacylglycerol kinase α exacerbates cardiac injury after ischemia/reperfusion.
1/2011Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure.
1/2009Diacylglycerol kinase zeta inhibits G(alpha)q-induced atrial remodeling in transgenic mice.
2/2008Diacylglycerol kinase zeta inhibits myocardial atrophy and restores cardiac dysfunction in streptozotocin-induced diabetes mellitus.
2/2008Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice.
9/2007Role of diacylglycerol kinase in cellular regulatory processes: a new regulator for cardiomyocyte hypertrophy.
2/2007Cardiac-specific overexpression of diacylglycerol kinase zeta attenuates left ventricular remodeling and improves survival after myocardial infarction.
2/2007Diacylglycerol kinase zeta attenuates pressure overload-induced cardiac hypertrophy.
1/2006Cardiac-specific overexpression of diacylglycerol kinase zeta prevents Gq protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice.
3/2005Adenovirus-mediated overexpression of diacylglycerol kinase-zeta inhibits endothelin-1-induced cardiomyocyte hypertrophy.

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Isao Kubota Research Topics

Disease

47Heart Failure
01/2018 - 05/2003
38Cardiovascular Diseases (Cardiovascular Disease)
02/2018 - 02/2005
12Myocardial Infarction
07/2018 - 07/2003
12Cardiomegaly (Heart Hypertrophy)
05/2016 - 01/2003
11Atrial Fibrillation
01/2016 - 01/2003
10Chronic Obstructive Pulmonary Disease (COPD)
01/2016 - 11/2003
10Hypertension (High Blood Pressure)
01/2015 - 05/2006
9Albuminuria
01/2018 - 01/2008
9Death (Near-Death Experience)
07/2012 - 02/2005
8Inflammation (Inflammations)
04/2014 - 11/2005
7Stroke (Strokes)
07/2018 - 06/2008
7Renal Insufficiency (Renal Failure)
05/2016 - 12/2003
7Obesity
01/2015 - 01/2007
6Peripheral Arterial Disease
01/2018 - 01/2015
6Coronary Artery Disease (Coronary Atherosclerosis)
08/2016 - 11/2006
6Body Weight (Weight, Body)
02/2014 - 11/2005
5Metabolic Syndrome (Dysmetabolic Syndrome X)
08/2016 - 01/2007
5Insulin Resistance
08/2016 - 04/2007
5Hypertrophy
05/2016 - 04/2004
5Ischemia
04/2016 - 07/2003
5Fibrosis (Cirrhosis)
09/2013 - 12/2003
4Anemia
02/2018 - 04/2014
4Chronic Renal Insufficiency
01/2018 - 07/2009
4Chronic Kidney Failure (Chronic Renal Failure)
01/2018 - 09/2002
4Ischemic Stroke
02/2017 - 08/2006
4Proteinuria
10/2016 - 03/2007
4Neoplasms (Cancer)
04/2015 - 10/2003
4Emphysema
01/2014 - 09/2006
4Edema (Dropsy)
01/2010 - 09/2002
3Diabetes Mellitus
01/2018 - 02/2008
3Cardiac Arrhythmias (Arrythmia)
11/2017 - 11/2003
3Infarction (Infarctions)
10/2017 - 12/2015
3Infections
01/2017 - 10/2006
3Ventricular Tachycardia
05/2016 - 12/2010
3Cardiotoxicity
01/2016 - 11/2007
3Hemorrhage
08/2015 - 06/2009
3Cardiomyopathies (Cardiomyopathy)
05/2015 - 11/2003
3Kidney Diseases (Kidney Disease)
01/2015 - 08/2013
3Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
01/2013 - 04/2002
3Type 2 Diabetes Mellitus (MODY)
06/2011 - 01/2008
3Tachycardia (Tachyarrhythmias)
01/2011 - 07/2006
3Ventricular Remodeling
02/2007 - 11/2002
2Hypoxia (Hypoxemia)
01/2020 - 01/2011
2Coronary Vasospasm (Coronary Artery Vasospasm)
01/2019 - 01/2011
2Cardiac Sudden Death (Sudden Cardiac Arrest)
07/2018 - 01/2011
2Myocardial Ischemia (Ischemic Heart Diseases)
01/2018 - 05/2003
2Atherosclerosis
01/2018 - 01/2016

Drug/Important Bio-Agent (IBA)

18Fatty Acid Binding Protein 3IBA
02/2018 - 02/2005
17Proteins (Proteins, Gene)FDA Link
04/2016 - 10/2003
15Brain Natriuretic Peptide (Natrecor)FDA Link
01/2015 - 08/2005
13CreatinineIBA
01/2018 - 10/2005
11Fatty Acid-Binding ProteinsIBA
02/2018 - 02/2005
10Uric Acid (Urate)IBA
01/2018 - 05/2006
10Diacylglycerol KinaseIBA
01/2014 - 03/2005
9EnzymesIBA
01/2014 - 10/2003
8AlbuminsIBA
08/2016 - 01/2007
8DiglyceridesIBA
01/2014 - 01/2006
8ImmunosorbentsIBA
01/2014 - 10/2003
7Protein Kinase CIBA
01/2014 - 03/2005
6LipidsIBA
12/2017 - 09/2007
6Collagen Type I (Type I Collagen)IBA
02/2017 - 12/2003
6CollagenIBA
02/2017 - 04/2002
6AdiponectinIBA
01/2016 - 08/2009
6Biomarkers (Surrogate Marker)IBA
01/2015 - 04/2004
6CytokinesIBA
01/2013 - 07/2006
5Reactive Oxygen Species (Oxygen Radicals)IBA
01/2019 - 07/2006
5Cystatin CIBA
01/2018 - 10/2005
5Interleukin-6 (Interleukin 6)IBA
01/2016 - 05/2008
5Angiotensin IIIBA
09/2013 - 04/2004
4MidkineIBA
01/2020 - 04/2010
4HMGB1 Protein (HMG1)IBA
10/2017 - 10/2008
4Troponin T (Troponin T1)IBA
03/2016 - 03/2007
4DNA (Deoxyribonucleic Acid)IBA
01/2016 - 10/2005
4PTX3 proteinIBA
12/2015 - 01/2008
4Indicators and Reagents (Reagents)IBA
03/2015 - 03/2007
4SodiumIBA
01/2015 - 04/2009
4C-Reactive ProteinIBA
01/2011 - 03/2005
3Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2020 - 01/2014
3Oxygen (Dioxygen)IBA
01/2018 - 11/2003
3Warfarin (Coumadin)FDA LinkGeneric
06/2016 - 01/2013
3Messenger RNA (mRNA)IBA
01/2016 - 12/2003
3Hemoglobins (Hemoglobin)IBA
01/2015 - 04/2009
3human NPPA protein (carperitide)IBA
01/2015 - 12/2013
3TolvaptanFDA Link
01/2015 - 12/2013
3Antihypertensive Agents (Antihypertensives)IBA
01/2015 - 07/2011
3SmokeIBA
01/2013 - 03/2007
3Glucose (Dextrose)FDA LinkGeneric
06/2011 - 01/2007
3Heat-Shock Proteins (Heat-Shock Protein)IBA
09/2008 - 12/2003
3Transforming Growth Factor beta1 (TGF beta 1)IBA
02/2007 - 12/2003
2ErbB Receptors (EGF Receptor)IBA
01/2020 - 05/2016
2Acetylcholine (Acetylcholine Chloride)FDA Link
01/2019 - 12/2010
2Xanthine DehydrogenaseIBA
01/2019 - 02/2017
2Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA
01/2018 - 03/2007

Therapy/Procedure

20Therapeutics
01/2018 - 01/2003
10Patient Readmission
07/2018 - 02/2005
5Catheter Ablation
05/2016 - 12/2010
4Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
12/2016 - 01/2011
4Percutaneous Coronary Intervention
01/2015 - 01/2013
3Secondary Prevention
12/2017 - 05/2012
3Renal Dialysis (Hemodialysis)
06/2009 - 09/2002