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John H Krystal Selected Research

Ketamine

9/2015Perceptual distortions and delusional thinking following ketamine administration are related to increased pharmacological MRI signal changes in the parietal lobe.
3/2015N-methyl-D-aspartate receptor antagonist effects on prefrontal cortical connectivity better model early than chronic schizophrenia.
2/2015Preliminary analysis of positive and negative syndrome scale in ketamine-associated psychosis in comparison with schizophrenia.
1/2015Ketamine and rapid-acting antidepressants: a window into a new neurobiology for mood disorder therapeutics.
4/2014Linking microcircuit dysfunction to cognitive impairment: effects of disinhibition associated with schizophrenia in a cortical working memory model.
1/2013Connectivity, pharmacology, and computation: toward a mechanistic understanding of neural system dysfunction in schizophrenia.
12/2012Effects of ketamine in treatment-refractory obsessive-compulsive disorder.
6/2012Glutamatergic modulation of auditory information processing in the human brain.
2/2011The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS.
7/2010Capgras syndrome induced by ketamine in a healthy subject.
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John H Krystal Research Topics

Disease

40Schizophrenia (Dementia Praecox)
12/2015 - 06/2002
20Alcoholism (Alcohol Abuse)
02/2015 - 07/2003
10Post-Traumatic Stress Disorders (PTSD)
10/2015 - 05/2008
8Psychotic Disorders (Schizoaffective Disorder)
01/2014 - 06/2002
7Mood Disorders (Mood Disorder)
01/2015 - 11/2003
7Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)
12/2012 - 05/2003
6Major Depressive Disorder (Major Depressive Disorders)
12/2014 - 05/2003
5Substance-Related Disorders (Drug Abuse)
09/2014 - 08/2006
5Anxiety Disorders (Anxiety Disorder)
08/2010 - 12/2004
3Panic Disorder (Panic Attack)
02/2010 - 03/2004
3Epilepsy (Aura)
08/2008 - 03/2002
3Substance Withdrawal Syndrome (Withdrawal Symptoms)
04/2007 - 09/2006
3Hallucinations (Hallucination)
04/2006 - 01/2003
2Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2008 - 01/2006
2Bipolar Disorder (Mania)
01/2008 - 04/2006
1Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
10/2015
1Neurobehavioral Manifestations
09/2015
1Cocaine-Related Disorders (Cocaine Addiction)
09/2014
1Tics (Tic)
01/2014
1Tourette Syndrome (Tourette's Syndrome)
01/2014
1Autistic Disorder (Autism)
07/2013
1Tobacco Use Disorder (Nicotine Dependence)
09/2011
1Wounds and Injuries (Trauma)
09/2011
1Sialorrhea
08/2011
1Fatigue
08/2011
1Weight Gain
08/2011
1Capgras Syndrome
07/2010
1Atrophy
08/2008
1Temporal Lobe Epilepsy
08/2008
1Borderline Personality Disorder (Personality Disorders, Borderline)
11/2005
1Seizures (Seizure)
02/2005
1Paranoid Disorders (Paranoia)
04/2002

Drug/Important Bio-Agent (IBA)

23N-Methylaspartate (NMDA)IBA
03/2015 - 07/2002
15Glutamic Acid (Glutamate)FDA Link
01/2015 - 11/2003
13KetamineFDA LinkGeneric
09/2015 - 09/2005
11gamma-Aminobutyric Acid (GABA)IBA
08/2008 - 03/2004
9Glutamate Receptors (Glutamate Receptor)IBA
03/2015 - 07/2003
8Ethanol (Ethyl Alcohol)IBA
10/2013 - 07/2003
6Risperidone (Risperdal Consta)FDA LinkGeneric
05/2014 - 03/2011
5Naltrexone (ReVia)FDA LinkGeneric
03/2012 - 03/2004
5RiluzoleFDA LinkGeneric
01/2008 - 05/2003
4Antidepressive Agents (Antidepressants)IBA
01/2015 - 01/2008
4NicotineFDA Link
01/2014 - 04/2004
4Antipsychotic Agents (Antipsychotics)IBA
01/2014 - 07/2005
3Memantine (Namenda)FDA Link
02/2015 - 04/2006
3Carbon MonoxideIBA
01/2015 - 04/2011
3Serotonin (5 Hydroxytryptamine)IBA
09/2011 - 01/2006
2Dopamine (Intropin)FDA LinkGeneric
01/2014 - 09/2012
2Haloperidol (Haldol)FDA LinkGeneric
01/2014 - 06/2009
2N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
10/2012 - 07/2005
2Cycloserine (Seromycin)FDA Link
06/2012 - 02/2010
2Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA
12/2011 - 06/2007
2Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA
09/2011 - 05/2008
2Biological Markers (Surrogate Marker)IBA
07/2011 - 10/2005
2Clozapine (Clozaril)FDA LinkGeneric
06/2009 - 07/2005
2Glutamine (L-Glutamine)FDA Link
08/2008 - 02/2005
2Excitatory Amino Acid AgentsIBA
05/2008 - 07/2003
2Butyric Acid (Butanoic Acid)IBA
03/2007 - 04/2005
2GABA-A Receptors (GABA(A) Receptor)IBA
09/2006 - 08/2005
2Protons (Proton)IBA
08/2006 - 02/2006
2salicylhydroxamic acid (SHAM)IBA
07/2005 - 01/2003
2Neurotransmitter Agents (Neurotransmitter)IBA
02/2005 - 11/2003
1Intergenic DNA (Junk DNA)IBA
10/2015
1serum-glucocorticoid regulated kinaseIBA
10/2015
1Histidine DecarboxylaseIBA
01/2014
1Norepinephrine Plasma Membrane Transport Proteins (Norepinephrine Transporter)IBA
11/2013
1Alcohol Dehydrogenase (Alcohol Dehydrogenase (NAD+))IBA
07/2013
1Dopamine AntagonistsIBA
09/2012
1Serotonin Uptake Inhibitors (Serotonin Reuptake Inhibitors)IBA
03/2012
1Norepinephrine (Noradrenaline)FDA LinkGeneric
03/2012
1Desipramine (Pertofrane)FDA LinkGeneric
03/2012
1Paroxetine (Paxil)FDA LinkGeneric
03/2012
1CannabidiolIBA
01/2011
1Endocannabinoids (Endocannabinoid)IBA
01/2011
1metabotropic glutamate receptor 2IBA
08/2010
1metabotropic glutamate receptor 5IBA
08/2010
1nicotinic receptor beta2IBA
05/2008
1lamotrigine (Lamictal)FDA LinkGeneric
12/2007
1A-factor (Streptomyces)IBA
04/2007
1Diazepam (Valium)FDA LinkGeneric
04/2007
1Glycine (Aminoacetic Acid)FDA LinkGeneric
12/2006
1SteroidsIBA
08/2006
1Bupropion (Wellbutrin)FDA LinkGeneric
04/2006
1Acetylcysteine (Siran)FDA LinkGeneric
01/2006
1Amphetamine (Amfetamine)FDA LinkGeneric
09/2005
1tranilast (N 5')IBA
07/2005
1CNS 1261IBA
07/2005
1Dizocilpine Maleate (Dizocilpine)IBA
07/2005
1BenzodiazepinesIBA
12/2004
1Clonazepam (Rivotril)FDA LinkGeneric
12/2004
1Disulfiram (Antabuse)FDA Link
03/2004
1RitanserinIBA
06/2002
11-(3-chlorophenyl)piperazineIBA
06/2002
1Cocaine (Cocaine HCl)IBA
04/2002
1Lactic AcidFDA LinkGeneric
03/2002

Therapy/Procedure

14Drug Therapy (Chemotherapy)
12/2015 - 09/2003
4Therapeutics
03/2015 - 05/2008
3Injections
01/2014 - 03/2011
1Self Medication
12/2006
1Intravenous Infusions
06/2002