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Jindřich Kopeček Selected Research

hydroxypropyl methacrylate

11/2015FRET-trackable biodegradable HPMA copolymer-epirubicin conjugates for ovarian carcinoma therapy.
6/2015Enhancing Accumulation and Penetration of HPMA Copolymer-Doxorubicin Conjugates in 2D and 3D Prostate Cancer Cells via iRGD Conjugation with an MMP-2 Cleavable Spacer.
1/2015Combination therapy of prostate cancer with HPMA copolymer conjugates containing PI3K/mTOR inhibitor and docetaxel.
8/2014Sequential combination therapy of ovarian cancer with degradable N-(2-hydroxypropyl)methacrylamide copolymer paclitaxel and gemcitabine conjugates.
5/2014Combination cytotoxicity of backbone degradable HPMA copolymer gemcitabine and platinum conjugates toward human ovarian carcinoma cells.
12/2013HPMA copolymer-based combination therapy toxic to both prostate cancer stem/progenitor cells and differentiated cells induces durable anti-tumor effects.
12/2013Spacer length impacts the efficacy of targeted docetaxel conjugates in prostate-specific membrane antigen expressing prostate cancer.
9/2013Biodegradable multiblock poly(N-2-hydroxypropyl)methacrylamide gemcitabine and paclitaxel conjugates for ovarian cancer cell combination treatment.
2/2013Synthesis and evaluation of a backbone biodegradable multiblock HPMA copolymer nanocarrier for the systemic delivery of paclitaxel.
2/2013Synthesis of long-circulating, backbone degradable HPMA copolymer-doxorubicin conjugates and evaluation of molecular-weight-dependent antitumor efficacy.
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Jindřich Kopeček Research Topics

Disease

13Neoplasms (Cancer)
11/2015 - 07/2011
7Carcinoma (Carcinomatosis)
11/2015 - 04/2012
7Prostatic Neoplasms (Prostate Cancer)
06/2015 - 08/2011
5Ovarian Neoplasms (Ovarian Cancer)
11/2015 - 04/2012
4Lymphoma (Lymphomas)
05/2015 - 01/2012
2B-Cell Lymphoma (Lymphoma, B Cell)
01/2015 - 01/2014
2Osteosarcoma (Osteogenic Sarcoma)
11/2014 - 07/2011
1Bone Fractures (Bone Fracture)
10/2015
1Neoplasm Metastasis (Metastasis)
01/2015
1Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
01/2015
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
12/2014
1Adenocarcinoma
12/2013

Drug/Important Bio-Agent (IBA)

15hydroxypropyl methacrylateIBA
11/2015 - 07/2011
6N-(2-hydroxypropyl)methacrylamideIBA
11/2015 - 03/2012
4docetaxel (Taxotere)FDA Link
01/2015 - 03/2012
3Doxorubicin (Adriamycin)FDA LinkGeneric
06/2015 - 04/2012
3Paclitaxel (Taxol)FDA LinkGeneric
08/2014 - 04/2012
3gemcitabineFDA Link
08/2014 - 09/2013
2MicellesIBA
11/2014 - 08/2011
2PolymersIBA
08/2014 - 04/2012
2cyclopamineIBA
12/2013 - 02/2012
1tranilast (N 5')IBA
11/2015
1Epirubicin (Ellence)FDA LinkGeneric
11/2015
1Aspartic Acid (Aspartate)FDA Link
10/2015
1Matrix Metalloproteinase 2 (Gelatinase A)IBA
06/2015
1Cathepsin BIBA
06/2015
1CD20 AntigensIBA
05/2015
1PeptidesIBA
05/2015
1AntibodiesIBA
01/2015
1rituximab (Mabthera)FDA Link
01/2015
1PlatinumIBA
05/2014
1Histone Deacetylase InhibitorsIBA
04/2014
1Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
04/2014
1Surface Antigens (Surface Antigen)IBA
01/2014
1human glutamate carboxypeptidase IIIBA
12/2013
1P-GlycoproteinIBA
04/2012
1OligosaccharidesIBA
04/2012
1chlorinIBA
04/2012
1Hyaluronic Acid (Hyaluronan)IBA
04/2012
1meso-chlorin e(6) monoethylene diamineIBA
04/2012
1AntigensIBA
03/2012
1Telomerase (Telomerase Reverse Transcriptase)IBA
02/2012
1O-(chloroacetylcarbamoyl)fumagillol (TNP 470)IBA
07/2011

Therapy/Procedure

7Heterologous Transplantation (Xenotransplantation)
11/2015 - 01/2012
6Therapeutics
01/2015 - 05/2014
2Drug Therapy (Chemotherapy)
01/2015 - 11/2014