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William E Klunk Selected Research

2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)

7/2015Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice.
12/2014Early detection of Alzheimer's disease using PiB and FDG PET.
9/2014Cognitive functioning in relation to brain amyloid-β in healthy adults with Down syndrome.
3/2014Amyloid burden and neural function in people at risk for Alzheimer's Disease.
1/2014Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury.
11/2013Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults.
4/2013Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia.
11/2012Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B.
9/2012Amyloid imaging in dementias with atypical presentation.
4/2012Anomalous PiB enhancement in the superior sagittal and transverse venous sinuses.
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William E Klunk Research Topics

Disease

67Alzheimer Disease (Alzheimer's Disease)
11/2015 - 01/2002
19Amyloid Plaque
07/2015 - 02/2002
17Dementia (Dementias)
11/2015 - 01/2008
6Atrophy
11/2014 - 08/2005
3Cerebral Amyloid Angiopathy (Congophilic Angiopathy)
11/2015 - 03/2007
3Amyloidosis
08/2015 - 12/2011
2Frontotemporal Lobar Degeneration (Semantic Dementia)
11/2015 - 01/2008
2Down Syndrome (Down's Syndrome)
09/2014 - 11/2012
2Stroke (Strokes)
09/2013 - 09/2007
1Multiple System Atrophy
11/2015
1Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
11/2015
1Tauopathies
11/2015
1Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy)
05/2015
1Frontotemporal Dementia
05/2015
1Pathologic Processes
12/2014
1Brain Injuries (Brain Injury)
01/2014
1Parkinson Disease (Parkinson's Disease)
10/2013
1Hypertension (High Blood Pressure)
09/2013
1Heart Diseases (Heart Disease)
09/2013
1Diabetes Mellitus
09/2013
1Trisomy (Trisomies)
11/2012
1Edema
02/2012
1Inflammation
02/2012
1Disease Progression
11/2010
1Hemorrhage
09/2007
1Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease)
07/2004
1Prion Diseases (Transmissible Spongiform Encephalopathies)
07/2004

Drug/Important Bio-Agent (IBA)

63Amyloid (Amyloid Fibrils)IBA
11/2015 - 02/2002
232- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA
07/2015 - 06/2003
10Biological Markers (Surrogate Marker)IBA
11/2015 - 10/2005
4N- methyl- 2- (4'- methylaminophenyl)- 6- hydroxybenzothiazoleIBA
01/2015 - 01/2008
4LigandsIBA
09/2013 - 07/2004
3Apolipoproteins E (ApoE)IBA
08/2015 - 05/2015
3ApolipoproteinsIBA
08/2015 - 01/2002
3Amyloid beta-PeptidesIBA
01/2009 - 01/2006
2bapineuzumabIBA
08/2015 - 04/2010
2Coloring Agents (Dyes)IBA
07/2015 - 11/2012
2CarbonIBA
01/2014 - 01/2009
2Glucose (Dextrose)FDA LinkGeneric
01/2008 - 01/2006
1DNA-Binding Proteins (DNA Binding Protein)IBA
11/2015
1SynucleinsIBA
11/2015
1protein TDP-43 (TDP-43)IBA
11/2015
1Acetic Acid (Vinegar)FDA LinkGeneric
07/2015
1glucuronyl glucosamine glycan sulfate (Vessel)IBA
11/2014
1CholesterolIBA
04/2014
1Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
03/2014
1TritiumIBA
01/2014
1Contrast MediaIBA
10/2013
1alpha-SynucleinIBA
10/2013
1Antipsychotic Agents (Antipsychotics)IBA
09/2013
1RheniumIBA
03/2013
1PresenilinsIBA
11/2012
1tau Proteins (tau Protein)IBA
08/2012
1Deoxycytidine (CDR)IBA
12/2009
1Deoxyglucose (2 Deoxy D glucose)IBA
11/2009
1PK 11195 (PK11195)IBA
08/2009
1amyloid beta-protein (1-42)IBA
06/2009
1Complement System Proteins (Complement)IBA
01/2008
1hydroxide ionIBA
01/2008
1Proteins (Proteins, Gene)IBA
01/2006
11,4- bis(3- carboxy- 4- hydroxyphenylethenyl)- benzeneIBA
01/2006
1Congo RedIBA
01/2006
1Presenilin-1IBA
11/2005
1Apolipoproteins D (Apo D)IBA
11/2005
11,4- bis(4'- hydroxystyryl)- 2- methoxybenzeneIBA
07/2004
1Acquired CJDIBA
07/2004
1Indicators and Reagents (Reagents)IBA
09/2002
12- (3'- iodo- 4'- aminophenyl)- 6- hydroxybenzothiazoleIBA
08/2002

Therapy/Procedure

2Therapeutics
10/2007 - 09/2002
1Home Nursing (Nursing, Home)
09/2013