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Yong-Chul Kim Selected Research

indirubin

4/20135'-OH-5-nitro-Indirubin oxime (AGM130), an Indirubin derivative, induces apoptosis of Imatinib-resistant chronic myeloid leukemia cells.
3/20105'-Nitro-indirubinoxime induces G1 cell cycle arrest and apoptosis in salivary gland adenocarcinoma cells through the inhibition of Notch-1 signaling.
6/2009Anti-tumor activity of noble indirubin derivatives in human solid tumor models in vitro.
1/2007Antitumor activity of novel indirubin derivatives in rat tumor model.
10/2006Enhancing effect of indirubin derivatives on 1,25-dihydroxyvitamin D3- and all-trans retinoic acid-induced differentiation of HL-60 leukemia cells.
1/2006Synthesis and structure-activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities.
9/2005Induction of apoptosis by a novel indirubin-5-nitro-3'-monoxime, a CDK inhibitor, in human lung cancer cells.

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Yong-Chul Kim Research Topics

Disease

19Neoplasms (Cancer)
11/2015 - 09/2005
5Pain (Aches)
08/2015 - 12/2003
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
02/2015 - 06/2012
3BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
04/2013 - 10/2006
2Necrosis
11/2015 - 01/2013
2Inflammation
10/2015 - 02/2012
2Leukemia
07/2008 - 10/2006
1Bradycardia
06/2015
1Hypotension (Low Blood Pressure)
06/2015
1Mouth Neoplasms (Oral Cancer)
04/2015
1Edema
03/2015
1Arthritis (Polyarthritis)
03/2015
1Body Weight (Weight, Body)
03/2014
1Alzheimer Disease (Alzheimer's Disease)
07/2013
1Albuminuria
01/2013
1IGA Glomerulonephritis (IGA Nephropathy)
01/2013
1Proteinuria
01/2013
1Lewis Lung Carcinoma
10/2012
1Fibrosis (Cirrhosis)
08/2012
1Myocarditis (Carditis)
02/2012
1Communicable Diseases (Infectious Diseases)
01/2012
1Infection
01/2012
1Rheumatoid Arthritis
04/2011
1Ganglion Cysts (Ganglion)
09/2010
1Adenocarcinoma
03/2010
1Cataract (Cataracts)
03/2009
1Genomic Instability
01/2009
1Ataxia Telangiectasia (Louis Bar Syndrome)
01/2009
1Takayasu Arteritis (Arteritis, Takayasu's)
06/2008
1T-Cell Leukemia (Leukemia, T Cell)
09/2007
1Colorectal Neoplasms (Colorectal Cancer)
12/2006
1Neurodegenerative Diseases (Neurodegenerative Disease)
10/2006
1Acute Promyelocytic Leukemia
10/2006

Drug/Important Bio-Agent (IBA)

7indirubinIBA
04/2013 - 09/2005
5pheophorbide aIBA
04/2015 - 09/2011
51-phenyl-3,3-dimethyltriazene (PDT)IBA
02/2015 - 11/2009
3Proliferating Cell Nuclear Antigen (PCNA)IBA
11/2015 - 11/2009
3Phosphotransferases (Kinase)IBA
06/2015 - 12/2006
3Adenosine Triphosphate (ATP)IBA
04/2011 - 10/2006
3Carbon MonoxideIBA
04/2011 - 07/2005
2AntigensIBA
11/2015 - 06/2012
2Purinergic P2X7 ReceptorsIBA
10/2015 - 10/2006
2Fibronectins (Fibronectin)IBA
03/2014 - 10/2012
2pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acidIBA
01/2013 - 07/2005
2Protein Kinases (Protein Kinase)IBA
08/2012 - 01/2009
2NAD (NADH)IBA
04/2011 - 06/2009
1MucinsIBA
11/2015
1Chloroquine (Aralen)FDA LinkGeneric
11/2015
1PolymersIBA
10/2015
1Opioid Analgesics (Opioids)IBA
08/2015
1DexmedetomidineFDA Link
06/2015
1Leuprolide (Lupron)FDA LinkGeneric
04/2015
1Folic Acid (Vitamin M)FDA LinkGeneric
04/2015
1cyclic (arginyl- glycyl- aspartyl- phenylalanyl- lysyl)IBA
04/2015
1Collagen Type II (Type II Collagen)IBA
03/2015
1CarrageenanIBA
03/2015
1docetaxel (Taxotere)FDA Link
03/2014
1Amyloid (Amyloid Fibrils)IBA
07/2013
1imatinib (Gleevec)FDA Link
04/2013
1Tacrolimus (Prograf)FDA LinkGeneric
01/2013
1pregabalin (Lyrica)FDA Link
01/2013
1ferric oxide (iron oxide)IBA
10/2012
1APTIBA
10/2012
1Adenosine Monophosphate (AMP)IBA
08/2012
1Angiotensin IIIBA
08/2012
1Photosensitizing Agents (Photosensitizers)IBA
06/2012
1Protease Inhibitors (Protease Inhibitor)IBA
02/2012
1Viral RNAIBA
02/2012
1Doxorubicin (Adriamycin)FDA LinkGeneric
09/2011
1ChlorineIBA
09/2011
1Paclitaxel (Taxol)FDA LinkGeneric
09/2011
1Ion Channels (Ion Channel)IBA
04/2011
1NitrogenIBA
04/2011
1Nicotinamide PhosphoribosyltransferaseIBA
04/2011
14- (2- chloro- 6- (3- chlorobenzylamino)- 9H- purin- 9- yl)- 2,3- dihydroxy- N- methylbicyclo(3.1.0)hexane- 1- carboxamideIBA
09/2010
1coomassie Brilliant BlueIBA
09/2010
1Sodium Chloride (Saline Solution)FDA LinkGeneric
09/2010
13'-O-(4-benzoyl)benzoyladenosine 5'-triphosphateIBA
09/2010
1Purinergic P1 Receptors (Adenosine Receptor)IBA
09/2010
1AdenosineFDA LinkGeneric
09/2010
14- (3- (4- benzoylpiperazin- 1- yl)- 2- (benzyloxycarbonylamino)- 3- oxopropyl)- 3,5- dimethylphenyl 4-methylbenzenesulfonateIBA
09/2010
1chlorin e6IBA
11/2009
1Cyclin-Dependent Kinases (cdk Proteins)IBA
06/2009
1DNA (Deoxyribonucleic Acid)IBA
01/2009
1ChromatinIBA
01/2009
11,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA
01/2009
1indirubin-3'-monoximeIBA
07/2008
1Cysteine (L-Cysteine)FDA Link
09/2007
1Serine (L-Serine)FDA Link
09/2007
1tautomycetinIBA
12/2006
1Calcitriol (Calcijex)FDA LinkGeneric
10/2006

Therapy/Procedure

6Photochemotherapy (Photodynamic Therapy)
04/2015 - 11/2009
2Heterologous Transplantation (Xenotransplantation)
11/2015 - 03/2014
1Activities of Daily Living (ADL)
08/2015
1Homologous Transplantation (Allograft)
03/2014
1Therapeutics
03/2010
1Chinese Traditional Medicine (Traditional Chinese Medicine)
06/2009
1Anesthesia
03/2009
1Analgesia
03/2009
1Angioplasty (Angioplasty, Transluminal)
06/2008