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E D Kharasch Selected Research

Alfentanil (Alfenta)

4/2012Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics.
7/2011Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction.
4/2011Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil.
10/2008Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities.
12/2001A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans.

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E D Kharasch Research Topics

Disease

6Miosis
04/2012 - 12/2001
2Necrosis
07/2003 - 02/2000
2Pain (Aches)
03/2003 - 08/2002
1Drug Toxicity (Drug Safety)
07/2008
1Hepatitis
07/2003
1Postoperative Pain
08/2002
1Amnesia (Dissociative Amnesia)
06/2001
1Diplopia (Double Vision)
06/2001
1Ataxia (Dyssynergia)
06/2001
1Gait Ataxia
06/2001

Drug/Important Bio-Agent (IBA)

5Alfentanil (Alfenta)FDA LinkGeneric
04/2012 - 12/2001
4Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
04/2012 - 02/2000
3Methadone (Dolophine)FDA LinkGeneric
04/2012 - 10/2008
3Cytochrome P-450 CYP3AIBA
07/2011 - 10/2008
2fexofenadine (Allegra)FDA LinkGeneric
04/2012 - 10/2008
2Ritonavir (Norvir)FDA Link
10/2008 - 10/2008
2Halothane (Fluothane)FDA Link
07/2003 - 02/2000
2Opioid Analgesics (Opioids)IBA
03/2003 - 08/2002
1efavirenz (Sustiva)FDA Link
04/2012
1S-mephenytoin N-demethylase (CYP2B6)IBA
04/2012
1P-GlycoproteinIBA
10/2008
1Anesthetics (Anesthetic Agents)IBA
07/2008
1CytochromesIBA
07/2003
1Proteins (Proteins, Gene)IBA
07/2003
1Meperidine (Pethidine)FDA LinkGeneric
08/2002
1Butorphanol (BC 2627)FDA LinkGeneric
08/2002
1Fentanyl (Sublimaze)FDA LinkGeneric
08/2002
1Midazolam (Versed)FDA LinkGeneric
12/2001
1Triazolam (Halcion)FDA LinkGeneric
06/2001