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Yoshihiro Keto Selected Research

ramosetron (Nasea)

5/2014Inhibitory effect of the selective serotonin 5-HT₃ receptor antagonist ramosetron on duodenal acidification-induced gastric hypersensitivity in rats.
5/2009[Pharmacological and clinical profile of ramosetron hydrochloride (Irribow), a novel therapeutic agent for irritable bowel syndrome with diarrhea].
2/2008Inhibitory effects of ramosetron, a potent and selective 5-HT3-receptor antagonist, on conditioned fear stress-induced abnormal defecation and normal defecation in rats: comparative studies with antidiarrheal and spasmolytic agents.
11/2007Effect of ramosetron on conditioned emotional stress-induced colonic dysfunction as a model of irritable bowel syndrome in rats.
7/2007Evaluation of the pharmacological profile of ramosetron, a novel therapeutic agent for irritable bowel syndrome.

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Yoshihiro Keto Research Topics

Disease

5Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
01/2019 - 07/2007
5Diarrhea
01/2019 - 07/2007
2Constipation
01/2019 - 01/2014
1Hyperalgesia
01/2019
1Hypersensitivity (Allergy)
05/2014
1Visceral Pain
01/2014
1Abdominal Pain (Pain, Abdominal)
01/2014
1Ulcer
04/2002
1Infections
04/2002
1Peptic Ulcer (Peptic Ulcers)
04/2002
1Stomach Ulcer (Gastric Ulcer)
04/2002

Drug/Important Bio-Agent (IBA)

5ramosetron (Nasea)IBA
05/2014 - 07/2007
4Serotonin (5 Hydroxytryptamine)IBA
05/2014 - 11/2007
2Pharmaceutical PreparationsIBA
01/2014 - 11/2007
2Loperamide (Imodium)FDA LinkGeneric
02/2008 - 07/2007
1linaclotideIBA
01/2019
15-HT3 Serotonin Receptors (5 HT3 Receptor)IBA
05/2014
12- (1,3- dimethyl- 2,6- dioxo- 1,2,3,6- tetrahydro- 7H- purin- 7- yl)- N- (4- isopropylphenyl)acetamideIBA
01/2014
1Analgesics (Analgesic Drugs)IBA
01/2014
1AnkyrinsIBA
01/2014
1(7- fluoro- 1- (2- methylpropyl)- 2- oxo- 1,2- dihydro- 3H- indol- 3- ylidene)acetic acidIBA
01/2014
1TrimebutineIBA
02/2008
1AntidiarrhealsIBA
02/2008
1Parasympatholytics (Antispasmodics)IBA
02/2008
1cilansetronIBA
07/2007
1alosetron (Lotronex)FDA Link
07/2007
1Acetic Acid (Vinegar)FDA LinkGeneric
04/2002
1Indomethacin (Indometacin)FDA LinkGeneric
04/2002
1Omeprazole (Prilosec)FDA LinkGeneric
04/2002
1Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
04/2002
1SolutionsIBA
04/2002

Therapy/Procedure

1Vagotomy
01/2014