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Richard E Kast Selected Research

Disulfiram (Antabuse)

4/2015The role of interleukin-18 in glioblastoma pathology implies therapeutic potential of two old drugs-disulfiram and ritonavir.
9/2014CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide.
1/2014Oxidizing to death: disulfiram for cancer cell killing.
1/2014Disulfiram/copper causes redox-related proteotoxicity and concomitant heat shock response in ovarian cancer cells that is augmented by auranofin-mediated thioredoxin inhibition.
10/2012Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide.
4/2012Matrix metalloproteinase-2 and -9 in glioblastoma: a trio of old drugs-captopril, disulfiram and nelfinavir-are inhibitors with potential as adjunctive treatments in glioblastoma.
12/2009Suppressing glioblastoma stem cell function by aldehyde dehydrogenase inhibition with chloramphenicol or disulfiram as a new treatment adjunct: an hypothesis.
2/2009Ritonavir and disulfiram have potential to inhibit caspase-1 mediated inflammation and reduce neurological sequelae after minor blast exposure.

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Richard E Kast Research Topics

Disease

19Neoplasms (Cancer)
08/2015 - 01/2003
18Glioblastoma (Glioblastoma Multiforme)
04/2015 - 01/2007
3Neoplasm Metastasis (Metastasis)
08/2015 - 01/2008
3Alcoholism (Alcohol Abuse)
04/2015 - 04/2012
3Glioma (Gliomas)
05/2011 - 11/2009
3Infection
10/2008 - 01/2002
2Oligodendroglioma
05/2011 - 01/2011
2Astrocytoma (Pilocytic Astrocytoma)
05/2011 - 01/2011
2Parkinson Disease (Parkinson's Disease)
02/2010 - 05/2006
2BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
02/2010 - 10/2008
2Progressive Multifocal Leukoencephalopathy
10/2008 - 01/2005
2Breast Neoplasms (Breast Cancer)
01/2007 - 04/2006
2Fatigue
09/2006 - 01/2005
2Crohn Disease (Crohn's Disease)
03/2005 - 10/2003
1HIV Infections (HIV Infection)
04/2015
1T-Cell Leukemia (Leukemia, T Cell)
01/2015
1Sleep Initiation and Maintenance Disorders (Insomnia)
01/2015
1Lymphoma (Lymphomas)
01/2015
1Necrosis
02/2014
1Ovarian Neoplasms (Ovarian Cancer)
01/2014
1Brain Neoplasms (Brain Tumor)
10/2012
1Hypertension (High Blood Pressure)
04/2012
1Rheumatoid Arthritis
10/2011
1Leprosy (Hansen's Disease)
10/2011
1Bullous Pemphigoid (Pemphigoid)
10/2011
1Dermatitis Herpetiformis (Disease, Duhring's)
10/2011
1Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
02/2010

Drug/Important Bio-Agent (IBA)

9temozolomide (Temodar)FDA LinkGeneric
04/2015 - 11/2009
8Disulfiram (Antabuse)FDA Link
04/2015 - 02/2009
8Bupropion (Wellbutrin)FDA LinkGeneric
09/2006 - 07/2003
7Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2006 - 01/2002
3Ritonavir (Norvir)FDA Link
04/2015 - 02/2009
2ChemokinesIBA
08/2015 - 05/2011
2Interleukin-2 (IL2)IBA
01/2015 - 01/2006
2Auranofin (Ridaura)FDA Link
09/2014 - 01/2014
2Captopril (Capoten)FDA LinkGeneric
09/2014 - 04/2012
2artesunateIBA
09/2014 - 02/2014
2aprepitant (Emend)FDA Link
09/2014 - 07/2009
2erlotinib (CP 358,774)FDA Link
09/2013 - 10/2011
2Epidermal Growth Factor Receptor (EGF Receptor)IBA
09/2013 - 01/2007
2Aldehyde DehydrogenaseIBA
04/2012 - 12/2009
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
10/2011 - 02/2010
2Acyclovir (Aciclovir)FDA LinkGeneric
01/2010 - 04/2006
2Fluvoxamine (Luvox)FDA LinkGeneric
11/2009 - 01/2006
2Ribavirin (Virazole)FDA LinkGeneric
10/2008 - 01/2003
2Interferon-alpha (Interferon Alfa)FDA Link
10/2008 - 01/2003
2Dopamine Agonists (Dopamine Agonist)IBA
04/2007 - 05/2006
2Zanamivir (Relenza)FDA Link
01/2007 - 12/2005
2Neuraminidase (Sialidase)IBA
01/2007 - 12/2005
2Oseltamivir (Tamiflu)FDA Link
01/2007 - 12/2005
2Antipsychotic Agents (Antipsychotics)IBA
01/2005 - 01/2005
2Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2004 - 01/2003
2Paroxetine (Paxil)FDA LinkGeneric
01/2004 - 01/2004
1Chemokine ReceptorsIBA
08/2015
1Interleukin-18 (Interleukin 18)IBA
04/2015
1Melatonin Receptors (Melatonin Receptor)IBA
01/2015
1MicroRNAs (MicroRNA)IBA
01/2015
1MelatoninIBA
01/2015
1ramelteon (Rozerem)FDA Link
01/2015
1S 20098 (agomelatine)IBA
01/2015
1Biological Markers (Surrogate Marker)IBA
01/2015
1Itraconazole (Sporanox)FDA LinkGeneric
09/2014
1Sertraline (Zoloft)FDA LinkGeneric
09/2014
1celecoxib (Celebrex)FDA Link
09/2014
1Annexin A5IBA
02/2014
1Drug CombinationsIBA
02/2014
1CopperIBA
01/2014
1ThioredoxinsIBA
01/2014
1NSC 23766IBA
09/2013
1Nelfinavir (Viracept)FDA Link
04/2012
1Matrix Metalloproteinase 9 (Gelatinase B)IBA
04/2012
1Matrix MetalloproteinasesIBA
04/2012
1Matrix Metalloproteinase 2 (Gelatinase A)IBA
04/2012
1HIV ProteaseIBA
04/2012
1Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
04/2012
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
04/2012
1DapsoneFDA Link
10/2011
1glucuronyl glucosamine glycan sulfate (Vessel)IBA
10/2011
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2011
1Interleukin-8 (Interleukin 8)IBA
10/2011
1Small Interfering RNA (siRNA)IBA
05/2011
1Caveolin 1IBA
01/2011
1Staphylococcal Protein A (A, Protein)IBA
01/2011
1Clotrimazole (Lotrimin)FDA LinkGeneric
10/2010
1mirtazapine (Rexer)FDA LinkGeneric
10/2010
1JM 3100FDA Link
10/2010
1Histamine (Histamine Dihydrochloride)FDA Link
10/2010
1Selegiline (E250)FDA LinkGeneric
02/2010
1imatinib (Gleevec)FDA Link
02/2010
1Methamphetamine (Desoxyn)FDA LinkGeneric
02/2010
1Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA
02/2010
1Chloramphenicol (Chloromycetin)FDA Link
12/2009
1Chloral HydrateIBA
12/2009
1donepezil (Aricept)FDA LinkGeneric
11/2009
1LigandsIBA
11/2009
1Memantine (Namenda)FDA Link
11/2009
1sigma-1 receptor (receptor 1, sigma)IBA
11/2009
1Dextromethorphan (Levomethorphan)FDA LinkGeneric
11/2009

Therapy/Procedure

7Drug Therapy (Chemotherapy)
04/2015 - 04/2006
1Heterologous Transplantation (Xenotransplantation)
01/2011