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Scott C Kachlany Selected Research

leukotoxin

11/2015Mechanisms of LtxA (Leukotoxin), a Potent New Anti-Inflammatory Agent for the Treatment of Alopecia Areata.
6/2015LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes.
8/2013Leukotoxin kills rodent WBC by targeting leukocyte function associated antigen 1.
11/2011In vitro synergism between LFA-1 targeting leukotoxin (Leukothera™) and standard chemotherapeutic agents in leukemia cells.
10/2011Resolution of psoriasis by a leukocyte-targeting bacterial protein in a humanized mouse model.
12/2010Gangliosides block Aggregatibacter Actinomycetemcomitans leukotoxin (LtxA)-mediated hemolysis.
9/2008Both leukotoxin and poly-N-acetylglucosamine surface polysaccharide protect Aggregatibacter actinomycetemcomitans cells from macrophage killing.

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Scott C Kachlany Research Topics

Disease

4Hemolysis
12/2010 - 04/2006
2Lymphoma (Lymphomas)
06/2015 - 11/2011
2Neoplasms (Cancer)
06/2015 - 01/2008
2Leukemia
11/2011 - 06/2010
2Infection
09/2008 - 06/2003
1Alopecia Areata
11/2015
1Asthma (Bronchial Asthma)
03/2015
1Pneumonia (Pneumonitis)
03/2015
1Hematologic Neoplasms (Hematological Malignancy)
08/2013
1Myeloid Leukemia (Leukemia, Myelocytic)
08/2013
1Necrosis
11/2011
1Acute Monocytic Leukemia (Acute Monoblastic Leukemia)
11/2011
1Psoriasis (Pustulosis Palmaris et Plantaris)
10/2011

Drug/Important Bio-Agent (IBA)

7leukotoxinIBA
11/2015 - 09/2008
4Lymphocyte Function-Associated Antigen-1 (LFA-1)IBA
03/2015 - 06/2010
2AntigensIBA
03/2015 - 11/2011
2Bacterial Proteins (Bacterial Protein)IBA
11/2011 - 10/2011
2AgarIBA
08/2008 - 04/2006
1Caspase 8 (Caspase-8)IBA
06/2015
1Interleukin-5 (Interleukin 5)IBA
03/2015
1Interleukin-17 (Interleukin 27)IBA
03/2015
1Interleukin-9 (Interleukin 9)IBA
03/2015
1Interleukin-4 (Interleukin 4)IBA
03/2015
1CytokinesIBA
03/2015
1Cathepsin DIBA
08/2013
1Mitoxantrone (Novantrone)FDA LinkGeneric
11/2011
1DNA (Deoxyribonucleic Acid)IBA
11/2011
1Busulfan (Busulfex)FDA Link
11/2011
1Annexin A5IBA
11/2011
1Daunorubicin (Cerubidine)FDA LinkGeneric
11/2011
1Adenosine Triphosphate (ATP)IBA
11/2011
1imatinib (Gleevec)FDA Link
11/2011
1Etoposide (VP 16)FDA LinkGeneric
11/2011
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
10/2011
1GangliosidesIBA
12/2010
1Prostaglandins A (PGA)IBA
09/2008
1Proteins (Proteins, Gene)IBA
01/2008
1Deferoxamine (Desferal)FDA LinkGeneric
12/2006
1IronIBA
12/2006
1tebufenozide (Mimic)IBA
06/2003

Therapy/Procedure

1Transplantation (Transplant Recipients)
10/2011
1Heterologous Transplantation (Xenotransplantation)
10/2011