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Alan H Jobe Selected Research

Betamethasone (Celestone)

1/2022Betamethasone phosphate reduces the efficacy of antenatal steroid therapy and is associated with lower birthweights when administered to pregnant sheep in combination with betamethasone acetate.
1/2018Extremely preterm fetal sheep lung responses to antenatal steroids and inflammation.
1/2018The efficacy of antenatal steroid therapy is dependent on the duration of low-concentration fetal exposure: evidence from a sheep model of pregnancy.
10/2016Antenatal corticosteroids beyond 34 weeks gestation: What do we do now?
1/2016The placental membrane microbiome is altered among subjects with spontaneous preterm birth with and without chorioamnionitis.
12/2013Modulation of lipopolysaccharide-induced chorioamnionitis in fetal sheep by maternal betamethasone.
1/2013Effects of intra-amniotic lipopolysaccharide and maternal betamethasone on brain inflammation in fetal sheep.
2/2012Intra-amniotic LPS and antenatal betamethasone: inflammation and maturation in preterm lamb lungs.
12/2009Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheep.
1/2009Ureaplasma colonization of amniotic fluid and efficacy of antenatal corticosteroids for preterm lung maturation in sheep.
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Alan H Jobe Research Topics

Disease

71Inflammation (Inflammations)
10/2023 - 02/2002
58Chorioamnionitis
02/2024 - 01/2002
38Pneumonia (Pneumonitis)
10/2023 - 02/2002
30Lung Injury
02/2024 - 06/2002
25Bronchopulmonary Dysplasia
10/2023 - 03/2002
23Premature Birth (Birth, Premature)
01/2024 - 05/2002
20Infections
09/2023 - 10/2010
14Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
01/2024 - 11/2002
8Premature Obstetric Labor (Premature Labor)
01/2022 - 01/2002
6Acute-Phase Reaction
01/2018 - 12/2009
4Brain Injuries (Brain Injury)
10/2023 - 04/2004
4Perinatal Death
11/2022 - 04/2004
4Lung Diseases (Lung Disease)
01/2022 - 01/2010
3Birth Weight (Birth Weights)
01/2022 - 01/2003
3Fetal Weight
01/2021 - 11/2003
3Hyperoxia
01/2020 - 12/2009
3Ureaplasma Infections (Ureaplasma Infection)
01/2017 - 09/2010
3Stillbirth
06/2016 - 12/2011
3Acidosis
06/2010 - 05/2002
3Body Weight (Weight, Body)
05/2010 - 03/2002
2Respiratory Insufficiency (Respiratory Failure)
01/2021 - 11/2019
2Pre-Eclampsia (Preeclampsia)
01/2021 - 05/2011
2Hyaline Membrane Disease
01/2020 - 02/2015
2Asphyxia (Suffocation)
08/2017 - 08/2015
2Hypertrophy
01/2016 - 12/2004
2Hypothermia
01/2009 - 10/2005
2Vascular Remodeling
01/2007 - 12/2004
2Fibrosis (Cirrhosis)
01/2007 - 12/2004
1Infant Death
01/2024
1Cardiovascular Diseases (Cardiovascular Disease)
11/2023
1COVID-19
01/2021

Drug/Important Bio-Agent (IBA)

32Surface-Active Agents (Surfactants)IBA
02/2024 - 03/2002
31CytokinesIBA
01/2022 - 03/2003
30LipopolysaccharidesIBA
11/2023 - 08/2005
28Adrenal Cortex Hormones (Corticosteroids)IBA
10/2023 - 11/2003
23EndotoxinsIBA
03/2011 - 02/2002
19Betamethasone (Celestone)FDA Link
01/2022 - 01/2002
19Messenger RNA (mRNA)IBA
01/2021 - 03/2003
16SteroidsIBA
02/2024 - 04/2003
13Proteins (Proteins, Gene)FDA Link
09/2014 - 06/2002
12Interleukin-1 (Interleukin 1)IBA
01/2018 - 03/2002
9Budesonide (Pulmicort)FDA LinkGeneric
02/2024 - 11/2003
9Oxygen (Dioxygen)IBA
01/2021 - 12/2009
8Interleukin-8 (Interleukin 8)IBA
01/2017 - 11/2003
8GlucocorticoidsIBA
03/2013 - 01/2002
6Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2022 - 07/2003
5InterleukinsIBA
01/2021 - 09/2014
5Anti-Bacterial Agents (Antibiotics)IBA
08/2017 - 10/2010
4LigandsIBA
01/2018 - 04/2009
4LipidsIBA
01/2017 - 06/2002
4AntigensIBA
01/2017 - 09/2010
4Interleukin-6 (Interleukin 6)IBA
01/2016 - 04/2009
3Saline SolutionIBA
01/2021 - 10/2002
3ChemokinesIBA
01/2017 - 03/2003
3Erythromycin (Erycette)FDA LinkGeneric
08/2014 - 10/2010
3Interleukin-1alpha (Interleukin 1 alpha)IBA
09/2006 - 03/2002
3acivicin (AT 125)IBA
01/2003 - 08/2002
2RNA (Ribonucleic Acid)IBA
01/2022 - 01/2021
2betamethasone sodium phosphateFDA LinkGeneric
01/2022 - 01/2018
2IronIBA
01/2021 - 01/2020
2Biomarkers (Surrogate Marker)IBA
01/2021 - 01/2021
2gamma-sitosterol (beta-sitosterol)IBA
05/2020 - 04/2019
2campesterolIBA
05/2020 - 04/2019
2Phytosterols (Plant Sterols)IBA
05/2020 - 04/2019
2Peroxidase (Myeloperoxidase)IBA
04/2019 - 05/2009
2Granulocyte Colony-Stimulating Factor (G-CSF)IBA
01/2017 - 11/2016
2Virulence Factors (Pathogenicity Factors)IBA
01/2017 - 01/2012
2CollagenIBA
01/2016 - 12/2004
2Fluconazole (Zonal)FDA LinkGeneric
01/2016 - 06/2015
2Oxidants (Oxidizing Agents)IBA
01/2015 - 03/2008
2Acute-Phase Proteins (Acute-Phase Protein)IBA
09/2013 - 12/2005
2Transforming Growth Factors (Transforming Growth Factor)IBA
03/2013 - 01/2007
2Hydrocortisone (Cortisol)FDA LinkGeneric
02/2011 - 01/2003
2Toll-Like Receptors (Toll-Like Receptor)IBA
01/2011 - 04/2009
2Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
05/2009 - 11/2005
2Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
04/2009 - 03/2003
2AT 130IBA
05/2005 - 03/2004
1Small Nuclear RNA (snRNA)IBA
01/2024
1Insulin-Like PeptidesIBA
05/2023
1Insulin-Like Growth Factor I (IGF-1)IBA
05/2023
1Insulin (Novolin)FDA Link
05/2023
1Acetates (Acetic Acid Esters)FDA Link
01/2022
1betamethasone acetateFDA LinkGeneric
01/2022
1Proto-Oncogene Proteins c-etsIBA
02/2021
1poractant alfa (Curosurf)FDA Link
01/2021
12-methylpentaneIBA
01/2021
1Volatile Organic CompoundsIBA
01/2021
1Granulocyte-Macrophage Colony-Stimulating Factor Receptors (GM-CSF Receptor)IBA
01/2021
1Interferon Type IIBA
01/2021

Therapy/Procedure

28Artificial Respiration (Mechanical Ventilation)
10/2023 - 02/2002
16Therapeutics
01/2024 - 01/2002
8Resuscitation
08/2017 - 10/2005
3Continuous Positive Airway Pressure
01/2024 - 09/2002
3Aftercare (After-Treatment)
11/2022 - 10/2002
2Prenatal Care (Care, Prenatal)
12/2011 - 05/2011
2Injections
12/2007 - 01/2002
1Mechanical Ventilators (Ventilator)
01/2024
1Off-Label Use
01/2021
1Bronchoscopes
01/2021
1Catheters
01/2021