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Peter Jenner Selected Research

istradefylline

11/2015The adenosine A2A receptor antagonist, istradefylline enhances anti-parkinsonian activity induced by combined treatment with low doses of L-DOPA and dopamine agonists in MPTP-treated common marmosets.
1/2015The adenosine A2A receptor antagonist, istradefylline enhances the anti-parkinsonian activity of low doses of dopamine agonists in MPTP-treated common marmosets.
7/2014Antidepressant activity of the adenosine A2A receptor antagonist, istradefylline (KW-6002) on learned helplessness in rats.
1/2014Adenosine A₂A-receptor antagonist istradefylline enhances the motor response of L-DOPA without worsening dyskinesia in MPTP-treated common marmosets.
6/2005Istradefylline, a novel adenosine A2A receptor antagonist, for the treatment of Parkinson's disease.

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Peter Jenner Research Topics

Disease

64Parkinson Disease (Parkinson's Disease)
11/2015 - 02/2002
46Dyskinesias (Dyskinesia)
11/2015 - 02/2002
5Chorea (Rheumatic Chorea)
12/2006 - 09/2002
4Inflammation
02/2012 - 01/2003
4Dystonia (Limb Dystonia)
12/2006 - 09/2003
3Disease Progression
01/2015 - 10/2011
2Parkinsonian Disorders (Parkinsonism)
12/2006 - 08/2002
2Infection
11/2004 - 10/2004
2Neurodegenerative Diseases (Neurodegenerative Disease)
07/2004 - 10/2002
2Hypokinesia (Bradykinesia)
06/2004 - 01/2003
2Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
07/2003 - 10/2002
1Ectodermal Dysplasia (Aplasia Cutis Congenita)
01/2015
1Restless Legs Syndrome (Restless Legs)
11/2014
1Vomiting
10/2014
1Shock
07/2014
1Lewy Body Disease (Lewy Body Dementia)
12/2012
1Neuroblastoma
10/2012
1Necrosis
02/2012
1Hypertrophy
12/2010
1Dementia (Dementias)
06/2008
1Gliosis
04/2005
1Tuberculosis (Tuberculoses)
11/2004

Drug/Important Bio-Agent (IBA)

51Levodopa (L Dopa)FDA LinkGeneric
11/2015 - 02/2002
341- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
10/2014 - 02/2002
20Dopamine Agonists (Dopamine Agonist)IBA
11/2015 - 02/2002
17Dopamine (Intropin)FDA LinkGeneric
12/2013 - 04/2002
8Dopamine Agents (Dopaminergic Agents)IBA
01/2015 - 09/2002
7Dopamine Receptors (Dopamine Receptor)IBA
07/2013 - 09/2002
6Oxidopamine (6 Hydroxydopamine)IBA
10/2013 - 09/2010
6pramipexol (pramipexole)FDA LinkGeneric
02/2010 - 10/2003
5Adenosine A2A Receptor (Adenosine A2A Receptors)IBA
11/2015 - 06/2005
5istradefyllineIBA
11/2015 - 06/2005
5Proteasome Endopeptidase Complex (Proteasome)IBA
12/2012 - 07/2002
4Carbon MonoxideIBA
11/2015 - 01/2004
4ropinirole (Requip)FDA LinkGeneric
01/2015 - 03/2007
4Serotonin (5 Hydroxytryptamine)IBA
07/2014 - 10/2003
4Proteins (Proteins, Gene)IBA
02/2014 - 08/2002
4OsteopontinIBA
08/2013 - 12/2004
4Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2011 - 08/2002
4Carbidopa (Lodosyn)FDA LinkGeneric
06/2010 - 03/2005
4entacapone (Comtan)FDA Link
12/2007 - 05/2003
3Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA
06/2015 - 08/2011
3Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
06/2015 - 11/2004
3Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA
01/2015 - 11/2003
3AdenosineFDA LinkGeneric
01/2014 - 12/2011
3UbiquitinIBA
12/2012 - 08/2002
3Superoxide DismutaseIBA
10/2012 - 04/2003
3BenserazideIBA
04/2012 - 04/2007
2Pergolide (Permax)FDA Link
01/2015 - 01/2003
2Glial Fibrillary Acidic ProteinIBA
01/2015 - 04/2005
21-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium)IBA
01/2015 - 12/2004
2Amantadine (Aman)FDA LinkGeneric
10/2014 - 12/2011
2N-Methylaspartate (NMDA)IBA
12/2011 - 05/2004
2catechol (pyrocatechol)IBA
12/2007 - 01/2003
2NeuropeptidesIBA
04/2007 - 02/2003
2N 0437FDA Link
03/2007 - 07/2005
22- n- butyl- 9- methyl- 8- (1,2,3)triazol- 2- yl- 9H- purin- 6- ylamineIBA
02/2007 - 09/2006
2Piribedil (Trivastal)IBA
05/2006 - 09/2002
2Haloperidol (Haldol)FDA LinkGeneric
11/2004 - 12/2003
2Messenger RNA (mRNA)IBA
11/2003 - 02/2003
2piperazineIBA
09/2002 - 09/2002
1IronIBA
11/2014
1Domperidone (Domperidon)IBA
10/2014
1Dizocilpine Maleate (Dizocilpine)IBA
10/2014
14-(1H-imidazol-4-ylmethyl)piperidineIBA
10/2014
1Histamine AgonistsIBA
10/2014
1Fluoxetine (Prozac)FDA LinkGeneric
07/2014
1Desipramine (Pertofrane)FDA LinkGeneric
07/2014
1Adenosine A2 Receptor AntagonistsIBA
01/2014
1Antidepressive Agents (Antidepressants)IBA
12/2013
1CoffeeFDA Link
03/2013
1CatalaseIBA
10/2012
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
10/2012
1Aromatic Amino Acids (Aromatic Amino Acid)IBA
04/2012
1Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
02/2012
1Histamine Receptors (Histamine Receptor)IBA
12/2011
1rasagiline (Azilect)FDA Link
11/2011
1Neuroprotective AgentsIBA
10/2011
1Tryptophan HydroxylaseIBA
12/2010
1SLV-308IBA
10/2010
1ProdrugsIBA
09/2010
1Dopa DecarboxylaseIBA
06/2010
1Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA
01/2010
1glycine amideIBA
04/2007
1tetralinIBA
12/2006
1sarizotanIBA
12/2006
1tandospironeIBA
12/2006
1RotenoneIBA
12/2004
1Arginine (L-Arginine)FDA Link
11/2004
1inulin trinicotinate monomethochloride (L-3)IBA
11/2004
1Calixarenes (Calixarene)IBA
11/2004
15-HT1B Serotonin ReceptorIBA
11/2004
1Monoamine Oxidase (MAO)IBA
10/2004
1Methionine (L-Methionine)FDA Link
10/2004
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
10/2004
1S 32504IBA
06/2004
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
05/2004

Therapy/Procedure

2Oral Administration
07/2014 - 05/2006
2Pallidotomy
12/2011 - 09/2005
2Denervation
09/2008 - 09/2003