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Nigel Irwin Selected Research

gastric inhibitory polypeptide receptor

1/2020Blockade of gastric inhibitory polypeptide (GIP) action as a novel means of countering insulin resistance in the treatment of obesity-diabetes.
2/2009Prolonged GIP receptor activation using stable mini-PEGylated GIP improves glucose homeostasis and beta-cell function in age-related glucose intolerance.
1/2009Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes.
6/2008Comparison of independent and combined chronic metabolic effects of GIP and CB1 receptor blockade in high-fat fed mice.
12/2007GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet.
6/2007Antagonistic effects of two novel GIP analogs, (Hyp3)GIP and (Hyp3)GIPLys16PAL, on the biological actions of GIP and longer-term effects in diabetic ob/ob mice.
2/2007Metabolic effects of sub-chronic ablation of the incretin receptors by daily administration of (Pro3)GIP and exendin(9-39)amide in obese diabetic (ob/ob) mice.
7/2006Biological activity and antidiabetic potential of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide, GIP(1-16) and (Pro3)GIP(1-16).
9/2005A novel, long-acting agonist of glucose-dependent insulinotropic polypeptide suitable for once-daily administration in type 2 diabetes.
8/2005Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes.

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Nigel Irwin Research Topics

Disease

53Body Weight (Weight, Body)
08/2022 - 09/2004
49Insulin Resistance
08/2022 - 09/2004
36Type 2 Diabetes Mellitus (MODY)
12/2021 - 12/2003
34Obesity
08/2022 - 08/2005
5Weight Loss (Weight Reduction)
12/2021 - 01/2015
4Glucose Intolerance
02/2009 - 02/2006
3Bone Resorption
10/2016 - 10/2013
2Metabolic Diseases (Metabolic Disease)
01/2022 - 01/2021
2Cognitive Dysfunction
11/2015 - 09/2010
2Hypertrophy
12/2007 - 08/2005
1Short Bowel Syndrome
01/2021
1Weight Gain
01/2020
1Body Weight Changes
01/2020
1Hypoglycemia (Reactive Hypoglycemia)
04/2018
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
12/2015
1Prediabetic State (Prediabetes)
11/2015
1Inflammation (Inflammations)
11/2014
1Insulinoma
10/2011
1Alzheimer Disease (Alzheimer's Disease)
09/2010
1Osteoporosis
09/2010
1Hyperphagia (Overeating)
02/2008

Drug/Important Bio-Agent (IBA)

55Glucose (Dextrose)FDA LinkGeneric
08/2022 - 08/2005
37Insulin (Novolin)FDA Link
08/2022 - 08/2005
29Peptides (Polypeptides)IBA
08/2022 - 09/2005
18Glucagon-Like Peptide 1 (GLP 1)IBA
08/2022 - 08/2006
13Glucagon (Glukagon)FDA Link
08/2022 - 12/2003
12xenin 25 (xenin)IBA
01/2021 - 08/2012
10gastric inhibitory polypeptide receptorIBA
01/2020 - 08/2005
7Exenatide (Byetta)FDA Link
08/2022 - 02/2009
7Blood Glucose (Blood Sugar)IBA
01/2022 - 01/2016
7IncretinsIBA
01/2020 - 12/2003
7Hormones (Hormone)IBA
01/2019 - 12/2003
7Pro(3)- glucose-dependent insulinotropic polypeptideIBA
07/2012 - 09/2004
6Streptozocin (Streptozotocin)FDA Link
01/2021 - 10/2011
6Triglycerides (Triacylglycerol)IBA
10/2020 - 12/2007
5Biological ProductsIBA
01/2021 - 06/2008
5Gastrointestinal Hormones (Hormones, Gastrointestinal)IBA
10/2013 - 09/2005
4Cholecystokinin (Pancreozymin)IBA
01/2018 - 08/2013
4OxyntomodulinIBA
01/2016 - 12/2013
4EnzymesIBA
12/2015 - 02/2009
3Pharmaceutical PreparationsIBA
01/2022 - 06/2008
3Sitagliptin Phosphate (Januvia)FDA Link
01/2021 - 01/2019
3Gastric Inhibitory Polypeptide (Glucose Dependent Insulinotropic Peptide)IBA
01/2020 - 01/2009
3Hypoglycemic Agents (Hypoglycemics)IBA
01/2018 - 10/2006
3(pGlu-Gln)-CCK-8IBA
08/2015 - 01/2013
3monomethoxypolyethylene glycol (MPEG)IBA
08/2013 - 06/2008
2Glucagon Receptors (Glucagon Receptor)IBA
08/2022 - 04/2014
2Glucagon-Like Peptide-1 ReceptorIBA
12/2021 - 04/2007
2Peptide YYIBA
01/2021 - 01/2018
2Cholecystokinin Receptors (Cholecystokinin Receptor)IBA
01/2021 - 01/2013
2Hydrocortisone (Cortisol)FDA LinkGeneric
01/2020 - 11/2016
2LiraglutideFDA Link
01/2020 - 03/2015
2AmylasesFDA Link
09/2018 - 01/2018
2Glucagon-Like Peptide-1 Receptor AgonistsIBA
12/2015 - 02/2010
2PalmitatesIBA
08/2012 - 02/2005
2Metformin (Glucophage)FDA LinkGeneric
12/2010 - 10/2006
2AdiponectinIBA
02/2009 - 06/2008
2CB1 Cannabinoid Receptor (CB1 Receptor)IBA
06/2008 - 02/2008
2CannabinoidsIBA
06/2008 - 02/2008
2AM 251 (AM251)IBA
06/2008 - 02/2008
2Glycated Hemoglobin (Glycosylated Hemoglobin)IBA
07/2007 - 04/2006
2Fatty Acids (Saturated Fatty Acids)IBA
02/2006 - 09/2005
1Vasopressins (Vasopressin)IBA
01/2022
1ApelinIBA
01/2022
1O-(Chloroacetylcarbamoyl)fumagillol (TNP 470)IBA
01/2021
1Pyruvic Acid (Pyruvate)IBA
01/2021
1Oxytocin (Pitocin)FDA LinkGeneric
01/2021
1methionine aminopeptidase 2IBA
01/2021
1AmidesIBA
12/2020
1AntibodiesIBA
01/2020
1Sodium-Glucose Transporter 2 InhibitorsIBA
01/2020
1Ala(2)- glucose-dependent insulinotropic polypeptideIBA
01/2020
1dapagliflozinIBA
01/2020
1LipidsIBA
01/2020
1peptide YY (1-36)IBA
01/2020
1GastrinsIBA
09/2018
1Peptide Hormones (Polypeptide Hormones)IBA
01/2018
1Glutamine (L-Glutamine)FDA Link
04/2016
1MineralsIBA
01/2016
1Leptin ReceptorsIBA
01/2016
1Proteins (Proteins, Gene)FDA Link
11/2014
18-hydroxyguanineIBA
11/2014
1deshistidyl(1)-prolyl(4)-glutamyl(9)- glucagonIBA
10/2014
1Peptide FragmentsIBA
05/2014
1Carbon MonoxideIBA
05/2014
1Olanzapine (Zyprexa)FDA Link
09/2013
1LDL CholesterolIBA
01/2013
1OvalbuminIBA
07/2012
1GhrelinIBA
09/2010
1ResistinIBA
02/2009
111-beta-Hydroxysteroid Dehydrogenase Type 1IBA
04/2008
1CarbenoxoloneIBA
04/2008
111-beta-Hydroxysteroid Dehydrogenases (11beta Hydroxysteroid Dehydrogenase)IBA
04/2008
1Dipeptidyl-Peptidase IV InhibitorsIBA
07/2007

Therapy/Procedure

14Therapeutics
01/2022 - 02/2005
4Injections
02/2009 - 09/2005
3Intraperitoneal Injections
12/2007 - 02/2006
1Bariatric Surgery
12/2021
1Transplantation
10/2011
1Glycemic Control
01/2009