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Peter J Houghton Selected Research

Heterologous Transplantation (Xenotransplantation)

11/2015Initial testing (stage 1) of the anti-microtubule agents cabazitaxel and docetaxel, by the pediatric preclinical testing program.
10/2015Inhibition of MEK confers hypersensitivity to X-radiation in the context of BRAF mutation in a model of childhood astrocytoma.
9/2015AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia.
9/2015Radiation therapy may increase metastatic potential in alveolar rhabdomyosarcoma.
8/2015Inhibition of MDM2 by RG7388 confers hypersensitivity to X-radiation in xenograft models of childhood sarcoma.
7/2015Initial testing (stage 1) of the tubulin binding agent nanoparticle albumin-bound (nab) paclitaxel (Abraxane(®)) by the Pediatric Preclinical Testing Program (PPTP).
6/2015Initial testing (stage 1) of BAL101553, a novel tubulin binding agent, by the pediatric preclinical testing program.
3/2015Effective targeting of the P53-MDM2 axis in preclinical models of infant MLL-rearranged acute lymphoblastic leukemia.
2/2015Synergistic activity of PARP inhibition by talazoparib (BMN 673) with temozolomide in pediatric cancer models in the pediatric preclinical testing program.
1/2015Preclinical Childhood Sarcoma Models: Drug Efficacy Biomarker Identification and Validation.
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Peter J Houghton Research Topics

Disease

126Neoplasms (Cancer)
12/2015 - 07/2002
32Sarcoma (Soft Tissue Sarcoma)
11/2015 - 08/2007
28Rhabdomyosarcoma
09/2015 - 04/2002
26Neuroblastoma
07/2015 - 09/2002
20Osteosarcoma (Osteogenic Sarcoma)
07/2015 - 10/2005
15Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
09/2015 - 01/2008
14Leukemia
09/2015 - 12/2007
11Wilms Tumor (Wilm's Tumor)
11/2014 - 12/2003
10Glioblastoma (Glioblastoma Multiforme)
10/2015 - 03/2008
8Medulloblastoma
02/2015 - 08/2004
7Anoxia (Hypoxia)
01/2014 - 12/2004
6Rhabdoid Tumor (Rhabdoid Tumors)
09/2011 - 05/2008
6Brain Neoplasms (Brain Tumor)
09/2008 - 09/2002
5Alveolar Rhabdomyosarcoma
08/2015 - 03/2008
4Diarrhea
08/2012 - 07/2002
4Breast Neoplasms (Breast Cancer)
10/2009 - 12/2003
4Alzheimer Disease (Alzheimer's Disease)
04/2007 - 03/2004
4Glioma (Gliomas)
02/2006 - 07/2002
3Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
09/2015 - 09/2014
3Neoplasm Metastasis (Metastasis)
09/2015 - 01/2006
3Carcinoma (Carcinomatosis)
06/2008 - 04/2002
2Hypersensitivity (Allergy)
10/2015 - 08/2015
2Astrocytoma (Pilocytic Astrocytoma)
12/2013 - 10/2010
2Lymphoma (Lymphomas)
07/2013 - 03/2006
2Glucose Intolerance
01/2012 - 05/2010
2Colonic Neoplasms (Colon Cancer)
08/2011 - 08/2009
2Ewing's Sarcoma (Sarcoma, Ewing)
07/2008 - 02/2004
2Body Weight (Weight, Body)
03/2008 - 05/2007
2Disease Progression
01/2006 - 06/2005

Drug/Important Bio-Agent (IBA)

39N- propyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (PPTP)IBA
11/2015 - 12/2007
19Sirolimus (Rapamycin)FDA Link
07/2013 - 04/2002
14irinotecan (Camptosar)FDA LinkGeneric
08/2012 - 07/2002
9Topotecan (Hycamtin)FDA LinkGeneric
11/2013 - 02/2003
8Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2014 - 05/2007
7Vincristine (Oncovin)FDA LinkGeneric
11/2015 - 08/2007
6temozolomide (Temodar)FDA LinkGeneric
02/2015 - 09/2002
6Insulin (Novolin)FDA Link
02/2015 - 06/2006
6Phosphotransferases (Kinase)IBA
06/2013 - 06/2004
5DNA (Deoxyribonucleic Acid)IBA
11/2014 - 09/2002
4AntibodiesIBA
12/2015 - 03/2012
4temsirolimusFDA Link
04/2015 - 08/2003
4Cisplatin (Platino)FDA LinkGeneric
02/2015 - 05/2008
4Insulin-Like Growth Factor I (IGF-1)IBA
06/2013 - 01/2003
4CytotoxinsIBA
04/2012 - 08/2007
4Eukaryotic Initiation Factor-4EIBA
09/2008 - 04/2002
4CamptothecinIBA
02/2005 - 12/2003
3TaxoidsIBA
11/2015 - 10/2005
3Insulin-Like Growth Factor II (Somatomedin A)IBA
02/2015 - 03/2012
3Biological Markers (Surrogate Marker)IBA
01/2015 - 03/2010
3Messenger RNA (mRNA)IBA
07/2013 - 02/2012
3gefitinib (Iressa)FDA Link
08/2012 - 10/2004
3Somatomedin Receptors (Somatomedin Receptor)IBA
05/2012 - 10/2009
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
04/2012 - 09/2002
3Type I DNA Topoisomerases (Topoisomerase I)IBA
05/2010 - 09/2002
3everolimusFDA Link
03/2010 - 08/2003
3Histone Deacetylase InhibitorsIBA
09/2009 - 01/2006
3AcetylcholinesteraseIBA
04/2007 - 03/2004
3Acetylcholine (Acetylcholine Chloride)FDA Link
04/2007 - 11/2004
2PR-104AIBA
09/2015 - 09/2011
2Dexamethasone (Maxidex)FDA LinkGeneric
09/2015 - 01/2010
2PR-104IBA
09/2015 - 09/2011
2RNA (Ribonucleic Acid)IBA
09/2015 - 10/2014
2Antimitotic AgentsIBA
07/2015 - 08/2013
2AZD1480IBA
02/2015 - 11/2014
2Janus KinasesIBA
02/2015 - 11/2014
2Angiogenesis InhibitorsIBA
11/2014 - 01/2014
2Adenosine Triphosphate (ATP)IBA
11/2014 - 12/2003
2ABT 263IBA
09/2014 - 06/2008
2AZD 6244IBA
12/2013 - 10/2010
2MicroRNAs (MicroRNA)IBA
07/2013 - 07/2013
2(5- (2,4- bis((3S)- 3- methylmorpholin- 4- yl)pyrido(2,3- d)pyrimidin- 7- yl)- 2- methoxyphenyl)methanolIBA
06/2013 - 02/2012
2Melphalan (Alkeran)FDA LinkGeneric
06/2013 - 02/2011
2LigandsIBA
06/2013 - 07/2010
24- ((4- Fluoro- 2- methyl- 1H- indol- 5- yl)oxy)- 6- methoxy- 7- (3- (pyrrolidin- 1- yl)propoxy)quinazoline (AZD2171)IBA
04/2012 - 03/2008
2MLN 8237IBA
11/2011 - 07/2010
2OxygenIBA
06/2011 - 11/2010
2Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
12/2010 - 03/2010
2EWS-FLI1 fusion proteinIBA
12/2010 - 03/2008
2sorafenib (BAY 43-9006)FDA Link
12/2010 - 08/2009
2Mitogen-Activated Protein Kinase 3IBA
03/2010 - 05/2007
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
10/2009 - 09/2009
2vorinostat (suberoylanilide hydroxamic acid)FDA Link
09/2009 - 08/2009
2FlavonoidsIBA
07/2008 - 03/2007
2Blood Glucose (Blood Sugar)IBA
03/2008 - 05/2007
2Paclitaxel (Taxol)FDA LinkGeneric
08/2007 - 10/2005
2Phosphatidylinositols (Phosphatidylinositol)IBA
05/2007 - 01/2003
2Carboxylesterase (Hydrolase S)IBA
12/2005 - 09/2002
2irofulvenIBA
05/2005 - 09/2002
2topovaleIBA
02/2005 - 12/2003
2Vinblastine (Vinblastine Sulfate)FDA Link
02/2004 - 07/2002
1Protein Isoforms (Isoforms)IBA
12/2015
14- acetoxy- 13- ((3- ((tert- butoxycarbonyl)amino)- 2- hydroxy- 3- phenylpropanoyl)oxy)- 1- hydroxy- 7,10- dimethoxy- 9- oxo- 5,20- epoxytax- 11- en- 2- yl benzoateFDA Link
11/2015
1docetaxel (Taxotere)FDA Link
11/2015

Therapy/Procedure

99Heterologous Transplantation (Xenotransplantation)
11/2015 - 09/2002
5Drug Therapy (Chemotherapy)
05/2013 - 09/2002
4Radiotherapy
09/2015 - 02/2006
4Therapeutics
08/2014 - 06/2004
2Withholding Treatment
07/2008 - 06/2008
2Traditional Medicine (Folk Remedies)
01/2005 - 11/2004
2Transplants (Transplant)
02/2004 - 09/2002