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Kevin A Hildebrand Selected Research

Ketotifen (Ketotifene)

1/2021The Dose-Response Effect of the Mast Cell Stabilizer Ketotifen Fumarate on Posttraumatic Joint Contracture: An in Vivo Study in a Rabbit Model.
12/2020PrEvention of Posttraumatic contractuRes with Ketotifen 1 (PERK 1): A Randomized Clinical Trial.
2/2020PrEvention of posttraumatic contractuRes with Ketotifen 2 (PERK 2) - protocol for a multicenter randomized clinical trial.
3/2017Serum Mast Cell Tryptase as a Marker of Posttraumatic Joint Contracture in a Rabbit Model.
4/2012The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures.
6/2010The mast cell stabilizer ketotifen fumarate lessens contracture severity and myofibroblast hyperplasia: a study of a rabbit model of posttraumatic joint contractures.
3/2008The mast cell stabilizer ketotifen prevents development of excessive skin wound contraction and fibrosis in red Duroc pigs.

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Kevin A Hildebrand Research Topics

Disease

17Contracture
01/2021 - 02/2004
7Fibrosis (Cirrhosis)
02/2020 - 03/2008
2Elbow Fractures
12/2020 - 01/2020
2Wounds and Injuries (Trauma)
01/2020 - 03/2008
1Rupture
10/2021
1Infections
01/2017
1Rheumatoid Arthritis
01/2017
1Tendon Injuries
11/2010
1Hyperplasia
06/2010

Drug/Important Bio-Agent (IBA)

7Ketotifen (Ketotifene)FDA Link
01/2021 - 03/2008
5Mast Cell StabilizersIBA
01/2021 - 03/2008
5NeuropeptidesIBA
02/2020 - 10/2008
5CollagenIBA
04/2012 - 10/2005
5Messenger RNA (mRNA)IBA
04/2012 - 10/2005
4Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
11/2013 - 03/2007
3Tryptases (Tryptase)IBA
01/2020 - 04/2012
2Substance PIBA
01/2021 - 11/2013
2Proteins (Proteins, Gene)FDA Link
04/2012 - 02/2004
2DecorinIBA
05/2006 - 10/2005
1Biomarkers (Surrogate Marker)IBA
01/2020
1Nerve Growth Factor (NGF)IBA
11/2013
1Transforming Growth Factor beta (TGF-beta)IBA
11/2013
1Connective Tissue Growth FactorIBA
03/2007
1Fibronectins (Fibronectin)IBA
03/2007
1Transforming Growth Factor beta1 (TGF beta 1)IBA
03/2007
1LumicanIBA
05/2006
1Tissue Inhibitor of Metalloproteinase-1IBA
05/2006
1Matrix Metalloproteinases (MMPs)IBA
10/2005
1BiglycanIBA
10/2005
1Capsules (Microcapsules)IBA
02/2004

Therapy/Procedure

2Therapeutics
03/2017 - 02/2004
1Early Ambulation
10/2021
1Activities of Daily Living (ADL)
01/2021
1Replantation
01/2017
1Arthroplasty
01/2017
1Sutures (Suture)
11/2010