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Shouichi Higashi Selected Research

Matrix Metalloproteinase 7 (Matrilysin)

3/2009Matrilysin (MMP-7) cleaves C-type lectin domain family 3 member A (CLEC3A) on tumor cell surface and modulates its cell adhesion activity.
12/2008Identification of amino acid residues of matrix metalloproteinase-7 essential for binding to cholesterol sulfate.
10/2008Matrilysin (matrix metalloprotease-7) cleaves membrane-bound annexin II and enhances binding of tissue-type plasminogen activator to cancer cell surfaces.
4/2006Binding of active matrilysin to cell surface cholesterol sulfate is essential for its membrane-associated proteolytic action and induction of homotypic cell adhesion.
11/2003Matrilysin (MMP-7) induces homotypic adhesion of human colon cancer cells and enhances their metastatic potential in nude mouse model.

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Shouichi Higashi Research Topics

Disease

15Neoplasms (Cancer)
06/2015 - 11/2003
7Carcinoma (Carcinomatosis)
08/2014 - 10/2003
5Colonic Neoplasms (Colon Cancer)
12/2008 - 11/2003
3Neoplasm Metastasis (Metastasis)
10/2008 - 11/2003
1Breast Neoplasms (Breast Cancer)
06/2015
1Stomach Neoplasms (Stomach Cancer)
12/2006
1Clear Cell Adenocarcinoma
02/2006
1Lung Neoplasms (Lung Cancer)
06/2005
1Fibrosarcoma
06/2003

Drug/Important Bio-Agent (IBA)

5Matrix Metalloproteinase 7 (Matrilysin)IBA
03/2009 - 11/2003
3Laminin (Merosin)IBA
06/2015 - 05/2011
3Carbon MonoxideIBA
08/2014 - 05/2011
3tumor-derived adhesion factorIBA
06/2014 - 10/2003
3Fibronectins (Fibronectin)IBA
01/2012 - 12/2008
3Protein SIBA
12/2008 - 11/2003
2CollagenIBA
08/2014 - 01/2012
2Conditioned Culture MediaIBA
08/2014 - 06/2005
2matriptaseIBA
12/2006 - 06/2005
2Serine Proteases (Serine Protease)IBA
12/2006 - 06/2005
1Biological Tumor Markers (Tumor Markers)IBA
06/2015
14- (5- benzo(1,3)dioxol- 5- yl- 4- pyridin- 2- yl- 1H- imidazol- 2- yl)benzamideIBA
08/2014
1Transforming Growth Factors (Transforming Growth Factor)IBA
08/2014
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
08/2014
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
06/2014
1Proteins (Proteins, Gene)IBA
03/2014
1Matrix Metalloproteinase 9 (Gelatinase B)IBA
03/2014
1Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA
02/2014
1Insulin-Like Growth Factor Binding ProteinsIBA
04/2012
1Glycoproteins (Glycoprotein)IBA
04/2012
1C-Type Lectins (C-Type Lectin)IBA
03/2009
1Annexin A2 (Annexin II)IBA
10/2008
1Tissue Plasminogen Activator (Alteplase)FDA Link
10/2008
1Matrix Metalloproteinase 3 (Stromelysin 1)IBA
12/2006
1betadex (beta-cyclodextrin)IBA
04/2006
1Matrix MetalloproteinasesIBA
04/2006
1Membrane Proteins (Integral Membrane Proteins)IBA
04/2006
1cholesteryl sulfateIBA
04/2006
1insulin-like growth factor binding protein-related protein 1IBA
02/2006
1Culture MediaIBA
06/2005
1Epidermal Growth Factor (EGF)IBA
06/2005
1TrypsinIBA
06/2005
1Cadherins (E-Cadherin)IBA
11/2003
1Carrier Proteins (Binding Protein)IBA
10/2003
1Insulin (Novolin)FDA Link
10/2003
1progelatinaseIBA
06/2003
1Concanavalin AIBA
06/2003