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Daniel F Heitjan Selected Research

lonidamine

3/2015Lonidamine induces intracellular tumor acidification and ATP depletion in breast, prostate and ovarian cancer xenografts and potentiates response to doxorubicin.
3/2015Effects of hyperglycemia on lonidamine-induced acidification and de-energization of human melanoma xenografts and sensitization to melphalan.
1/2013(31) P and (1) H MRS of DB-1 melanoma xenografts: lonidamine selectively decreases tumor intracellular pH and energy status and sensitizes tumors to melphalan.

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Daniel F Heitjan Research Topics

Disease

18Neoplasms (Cancer)
03/2015 - 03/2004
6Melanoma (Melanoma, Malignant)
03/2015 - 03/2004
5Breast Neoplasms (Breast Cancer)
03/2015 - 01/2002
3Tobacco Use Disorder (Nicotine Dependence)
02/2015 - 11/2008
3Renal Cell Carcinoma (Grawitz Tumor)
01/2014 - 04/2008
3Colonic Neoplasms (Colon Cancer)
03/2007 - 03/2002
2Hyperglycemia
03/2015 - 03/2004
2Carcinoma (Carcinomatosis)
03/2015 - 03/2009
2Neutropenia
06/2013 - 04/2010
2Fatigue
06/2013 - 11/2008
2Hypertension (High Blood Pressure)
02/2010 - 07/2009
2Hyperuricemia
02/2010 - 07/2009
2Stroke (Strokes)
02/2010 - 07/2009
2Chronic Granulomatous Disease
04/2008 - 01/2004
1Adenocarcinoma
10/2015
1Retinoblastoma (Glioblastoma, Retinal)
03/2015
1Ovarian Neoplasms (Ovarian Cancer)
03/2015
1Glioblastoma (Glioblastoma Multiforme)
08/2014
1Intractable Pain
06/2013
1Nausea
06/2013
1Vomiting
06/2013
1Pancreatic Neoplasms (Pancreatic Cancer)
06/2013
1Fever (Fevers)
01/2013
1Graft vs Host Disease (Graft-Versus-Host Disease)
07/2012
1Multiple Myeloma
12/2011
1Obesity
12/2011
1Overweight
12/2011
1Septic Shock (Toxic Shock Syndrome)
04/2010
1Hematologic Neoplasms (Hematological Malignancy)
04/2010
1Pleural Effusion (Pleural Effusions)
04/2010
1Mesothelioma
04/2010
1Malignant Pleural Effusion
04/2010
1Coronary Disease (Coronary Heart Disease)
02/2010
1Cardiovascular Diseases (Cardiovascular Disease)
02/2010
1Diabetes Mellitus
07/2009
1Substance Withdrawal Syndrome (Withdrawal Symptoms)
11/2008
1Cocaine-Related Disorders (Cocaine Addiction)
11/2008

Drug/Important Bio-Agent (IBA)

6Melphalan (Alkeran)FDA LinkGeneric
03/2015 - 03/2004
3Lactic AcidFDA LinkGeneric
03/2015 - 04/2010
3lonidamineIBA
03/2015 - 01/2013
3Hydroxychloroquine (Plaquenil)FDA LinkGeneric
08/2014 - 08/2014
3Estrogens (Estrogen)FDA Link
09/2013 - 07/2012
3HormonesIBA
09/2013 - 07/2012
3Aromatase InhibitorsIBA
09/2013 - 07/2012
3Fluorouracil (Carac)FDA LinkGeneric
06/2013 - 03/2002
3Uric Acid (Urate)IBA
02/2010 - 05/2006
2triphosphoric acid (triphosphate)IBA
03/2015 - 01/2013
2Adenosine Triphosphate (ATP)IBA
03/2015 - 03/2015
2temozolomide (Temodar)FDA LinkGeneric
08/2014 - 08/2014
2Phosphotransferases (Kinase)IBA
01/2014 - 06/2008
2Angiogenesis InhibitorsIBA
01/2013 - 04/2008
2sorafenib (BAY 43-9006)FDA Link
01/2013 - 04/2008
2GadoliniumIBA
01/2013 - 04/2008
2TamoxifenFDA LinkGeneric
07/2012 - 01/2002
1Folic Acid (Vitamin M)FDA LinkGeneric
10/2015
1Carbonic AcidIBA
03/2015
1Doxorubicin (Adriamycin)FDA LinkGeneric
03/2015
16- acetyl- 8- cyclopentyl- 5- methyl- 2- (5- piperazin- 1- ylpyridin- 2- ylamino)- 8H- pyrido(2,3- d)pyrimidin- 7- oneIBA
03/2015
1Mechlorethamine (Nitrogen Mustard)FDA Link
03/2015
1Glucose (Dextrose)FDA LinkGeneric
03/2015
1Carbon DioxideIBA
03/2015
1Antineoplastic Agents (Antineoplastics)IBA
03/2015
1A-factor (Streptomyces)IBA
03/2015
1AnthracyclinesIBA
03/2015
1Retinoblastoma ProteinIBA
03/2015
1temsirolimusFDA Link
08/2014
1AntibodiesIBA
12/2013
1Keratins (Keratin)IBA
12/2013
1Conjugated (USP) Estrogens (Premarin)FDA Link
09/2013
1Medroxyprogesterone Acetate (Depo-Provera)FDA LinkGeneric
09/2013
1Estrogen Receptor Modulators (Antiestrogen)IBA
08/2013
1gemcitabineFDA Link
06/2013
1oxaliplatin (Eloxatin)FDA LinkGeneric
06/2013
1Platinum Compounds (Compounds, Platinum)IBA
06/2013
1bevacizumabFDA Link
06/2013
1Biological Markers (Surrogate Marker)IBA
01/2013
1Alkylating AgentsIBA
01/2013
1Choline O-Acetyltransferase (Choline Acetyltransferase)IBA
05/2010
1Anti-Bacterial Agents (Antibiotics)IBA
04/2010
1Interferon-betaIBA
04/2010
1CholesterolIBA
07/2009
1megakaryocyte potentiating factorIBA
03/2009
1modafinil (armodafinil)FDA Link
11/2008
1NicotineFDA Link
11/2008
1Transforming Growth Factor beta Receptors (TGF beta Receptors)IBA
06/2008
1Messenger RNA (mRNA)IBA
06/2008
1OvalbuminIBA
06/2008
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2008
1ArginaseIBA
06/2008

Therapy/Procedure

9Heterologous Transplantation (Xenotransplantation)
03/2015 - 03/2004
9Drug Therapy (Chemotherapy)
02/2015 - 03/2002
3Immunotherapy
03/2009 - 01/2004
2Hematopoietic Stem Cell Transplantation
07/2012 - 12/2011
2Adjuvant Chemotherapy
06/2002 - 03/2002
1Radiotherapy
06/2013
1Withholding Treatment
06/2013
1Therapeutics
01/2013
1Autologous Transplantation
12/2011
1Transplants (Transplant)
12/2011
1Length of Stay
04/2010