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Jacqueline T Hecht Selected Research

Pseudoachondroplasia

7/2014Pseudoachondroplasia/COMP - translating from the bench to the bedside.
2/2012Chop (Ddit3) is essential for D469del-COMP retention and cell death in chondrocytes in an inducible transgenic mouse model of pseudoachondroplasia.
1/2010RNAi reduces expression and intracellular retention of mutant cartilage oligomeric matrix protein.
4/2009Ribozyme-mediated reduction of wild-type and mutant cartilage oligomeric matrix protein (COMP) mRNA and protein.
6/2008Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen.
2/2008COMP mutations: domain-dependent relationship between abnormal chondrocyte trafficking and clinical PSACH and MED phenotypes.
1/2007Unique matrix structure in the rough endoplasmic reticulum cisternae of pseudoachondroplasia chondrocytes.
4/2006Expression of mutant cartilage oligomeric matrix protein in human chondrocytes induces the pseudoachondroplasia phenotype.
3/2006Retention of the matricellular protein SPARC in the endoplasmic reticulum of chondrocytes from patients with pseudoachondroplasia.
12/2005In vivo human Cartilage oligomeric matrix protein (COMP) promoter activity.
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Jacqueline T Hecht Research Topics

Disease

11Osteochondrodysplasias (Spondyloepiphyseal Dysplasia)
02/2012 - 03/2002
7Cleft Lip (Harelip)
07/2011 - 09/2005
5Osteoarthritis
07/2014 - 06/2004
4Clubfoot (Talipes Equinovarus)
05/2014 - 09/2007
3Congenital Abnormalities (Deformity)
08/2014 - 02/2010
2Contracture
05/2014 - 01/2013
2Cleft Palate (Palate, Cleft)
05/2014 - 07/2011
2Arthrogryposis
05/2014 - 01/2013
2Exostoses
06/2005 - 09/2002
1Achondroplasia
01/2014
1Inflammation
01/2014
1Necrosis
02/2012
1Neural Tube Defects (Exencephaly)
01/2011
1Fever (Fevers)
03/2010
1Down Syndrome (Down's Syndrome)
02/2010
1Trisomy (Trisomies)
02/2010
1Polydactyly (Polydactylism)
11/2008
1Dwarfism
03/2006
1Metabolic Bone Diseases (Osteopenia)
03/2006
1Genetic Translocation (Chromosomal Translocation)
02/2004

Drug/Important Bio-Agent (IBA)

15PseudoachondroplasiaIBA
07/2014 - 03/2002
6cartilage matrix proteinIBA
01/2010 - 03/2002
3DNA (Deoxyribonucleic Acid)IBA
05/2014 - 09/2002
3Glycoproteins (Glycoprotein)IBA
01/2010 - 04/2006
2Contractile ProteinsIBA
01/2013 - 09/2011
2Folic Acid (Vitamin M)FDA LinkGeneric
01/2011 - 01/2011
2styrene-methylmethacrylate copolymerIBA
11/2010 - 09/2007
2nectinsIBA
10/2009 - 07/2009
1Congenital Talipes EquinovarusIBA
08/2014
1Marden-Walker syndromeIBA
05/2014
1Gordon syndromeIBA
05/2014
1Proteins (Proteins, Gene)IBA
01/2014
1Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA
01/2014
1Multiple synostoses syndrome 2IBA
01/2013
1Apoptosis Inducing FactorIBA
02/2012
1CaspasesIBA
02/2012
1Cysteine (L-Cysteine)FDA Link
07/2011
1AntipyreticsIBA
03/2010
1Patau syndromeIBA
02/2010
1Absence of TibiaIBA
11/2008
1Collagen Type IXIBA
06/2008
1Intervertebral disc diseaseIBA
03/2006
1InterferonsIBA
09/2005
1Van der Woude syndromeIBA
09/2005
1Heparitin Sulfate (Heparan Sulfate)IBA
06/2005
1Proteoglycans (Proteoglycan)IBA
06/2005
1perlecanIBA
06/2005
1Transcription Factors (Transcription Factor)IBA
02/2004
1Extracellular Matrix ProteinsIBA
03/2002