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C Oliver Hanemann Selected Research

Neurofibromin 2 (Merlin)

7/2014Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus.
4/2013Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy.
2/2013Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells.
11/2012The role of insulin-like growth factors signaling in merlin-deficient human schwannomas.
5/2012Merlin, a multi-suppressor from cell membrane to the nucleus.
4/2012The tumor suppressor merlin controls growth in its open state, and phosphorylation converts it to a less-active more-closed state.
8/2011Merlin/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression.
7/2011Emerging therapeutic targets in schwannomas and other merlin-deficient tumors.
8/2010ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma.
2/2010Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.
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C Oliver Hanemann Research Topics

Disease

19Neoplasms (Cancer)
07/2014 - 06/2003
17Neurilemmoma (Schwannoma)
03/2013 - 06/2003
11Neurofibromatosis 2 (Neurofibromatosis Type II)
11/2013 - 07/2003
7Meningioma (Meningiomas)
03/2013 - 07/2003
4Neurofibromatosis 1 (Neurofibromatosis Type I)
01/2015 - 01/2004
4Neurofibromatoses (Neurofibromatosis)
03/2014 - 03/2013
4Nervous System Neoplasms (Neoplasms, Nervous System)
11/2012 - 01/2009
4Ependymoma
11/2012 - 01/2010
2Pain (Aches)
03/2014 - 11/2013
2Acoustic Neuroma (Acoustic Neurinoma)
03/2013 - 08/2010
2Glioma (Gliomas)
03/2012 - 06/2005
1Rare Diseases (Rare Disease)
03/2014
1Deglutition Disorders (Dysphagia)
12/2013
1Hematologic Neoplasms (Hematological Malignancy)
08/2013
1Costello Syndrome
08/2013
1LEOPARD Syndrome (Syndrome, LEOPARD)
08/2013
1Neuroblastoma
08/2013
1Noonan Syndrome (Female Pseudo-Turner Syndrome)
08/2013
1Polyneuropathies (Polyneuropathy)
04/2013
1Rhabdoid Tumor (Rhabdoid Tumors)
03/2013
1Inborn Genetic Diseases (Disease, Hereditary)
11/2012
1Neurofibroma
03/2012
1Multiple Sclerosis
09/2011
1Renal Cell Carcinoma (Grawitz Tumor)
07/2008
1Motor Neuron Disease (Primary Lateral Sclerosis)
12/2005
1Prostatic Neoplasms (Prostate Cancer)
04/2005
1Nerve Sheath Neoplasms (Nerve Sheath Neoplasm)
04/2005
1Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy)
04/2003
1Gynecomastia
12/2002
1Tremor (Tremors)
12/2002

Drug/Important Bio-Agent (IBA)

18Neurofibromin 2 (Merlin)IBA
07/2014 - 06/2003
6Phosphotransferases (Kinase)IBA
07/2011 - 01/2004
4SchwannomatosisIBA
03/2014 - 03/2012
3Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
02/2013 - 07/2008
2Messenger RNA (mRNA)IBA
02/2013 - 06/2003
2tyrosine receptor (receptor, tyrosine)IBA
07/2011 - 08/2010
1Protein Kinases (Protein Kinase)IBA
01/2015
1Botulinum Toxins (Botulinum Toxin)IBA
12/2013
1Biological Markers (Surrogate Marker)IBA
11/2013
1Legius syndromeIBA
08/2013
1Cardiofaciocutaneous syndromeIBA
08/2013
1Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)IBA
02/2013
1Transcription Factors (Transcription Factor)IBA
02/2013
1Insulin-Like Growth Factor I (IGF-1)IBA
11/2012
1IGF Type 1 Receptor (IGF 1 Receptor)IBA
11/2012
1Somatomedins (Somatomedin)IBA
11/2012
1CannabinoidsIBA
09/2011
1Phospholipase DIBA
09/2011
1phosphatidylethanolamineIBA
09/2011
1Cannabinoid Receptors (Cannabinoid Receptor)IBA
09/2011
1moesinIBA
08/2011
1ezrinIBA
08/2011
1radixinIBA
08/2011
1Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
07/2011
1Insulin (Novolin)FDA Link
07/2011
1lapatinib (GW572016)FDA Link
08/2010
1Platelet-Derived Growth FactorIBA
01/2010
1AZD 6244IBA
01/2010
1GuanineIBA
01/2009
1rho-Associated KinasesIBA
01/2009
1Growth Factor ReceptorsIBA
07/2008
1sorafenib (BAY 43-9006)FDA Link
07/2008
1Mitogen-Activated Protein Kinase 3IBA
07/2008
1Proteins (Proteins, Gene)IBA
12/2005
1Tyrosine (L-Tyrosine)FDA Link
06/2005
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
06/2005
1GelsolinIBA
04/2005
1Histone Deacetylases (Histone Deacetylase)IBA
04/2005
1romidepsin (FK228)FDA Link
04/2005
1Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
04/2005
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
02/2005
1Complementary DNA (cDNA)IBA
02/2005
13,9-bis((ethylthio)methyl)-K-252aIBA
01/2004
1IntegrinsIBA
07/2003
1connexin 32IBA
04/2003
1Creatine Kinase (Creatine Phosphokinase)IBA
12/2002

Therapy/Procedure

2Drug Therapy (Chemotherapy)
07/2011 - 01/2010
1Radiotherapy
07/2011
1Heterologous Transplantation (Xenotransplantation)
04/2005