P-Glycoprotein

A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).

Also Known As:

ATP-Binding Cassette, Sub-Family B, Member 1; P-gp; PGY-1 Protein; P Glycoprotein; PGY 1 Protein; MDR1 Protein; Multidrug Resistance Protein 1

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Glycoproteins: 18176
    - Membrane Glycoproteins: 1848
      - ATP-Binding Cassette Transporters: 676
        P-Glycoproteins: 190
        P-Glycoprotein: 5596
  - Carrier Proteins: 11456
    - Membrane Transport Proteins: 165
      - ATP-Binding Cassette Transporters: 676
        P-Glycoproteins: 190
        P-Glycoprotein: 5596
      - Ion Pumps: 30
        Anion Transport Proteins: 2
        Organic Anion Transporters: 63
        ATP-Dependent Organic Anion Transporters
        P-Glycoprotein: 5596
  - Membrane Proteins: 5300
    - Membrane Glycoproteins: 1848
      - ATP-Binding Cassette Transporters: 676
        P-Glycoproteins: 190
        P-Glycoprotein: 5596
    - Membrane Transport Proteins: 165
      - ATP-Binding Cassette Transporters: 676
        P-Glycoproteins: 190
        P-Glycoprotein: 5596
      - Ion Pumps: 30
        Anion Transport Proteins: 2
        Organic Anion Transporters: 63
        ATP-Dependent Organic Anion Transporters
        P-Glycoprotein: 5596

H Guy Selected Research

H Guy Research Topics

Disease

Drug/Important Bio-Agent (IBA)