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Kun-Liang Guan Selected Research

Long-Acting Thyroid Stimulator (LATS)

7/2012The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition.
6/2010The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation.
4/2008TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway.
11/2007Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.

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Kun-Liang Guan Research Topics

Disease

44Neoplasms (Cancer)
12/2015 - 04/2002
11Tuberous Sclerosis (Bourneville's Disease)
11/2014 - 04/2003
9Starvation
12/2015 - 11/2003
4Obesity
01/2015 - 04/2009
3Colorectal Neoplasms (Colorectal Cancer)
06/2015 - 08/2012
3Breast Neoplasms (Breast Cancer)
05/2015 - 07/2012
2Glioma (Gliomas)
12/2015 - 01/2011
2Inflammation
03/2015 - 10/2003
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
02/2015 - 01/2011
2Hypertrophy
02/2014 - 04/2008
2Diabetic Nephropathies (Diabetic Nephropathy)
10/2011 - 07/2009
2Anoxia (Hypoxia)
04/2009 - 12/2007
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
03/2015
1Carcinoma (Carcinomatosis)
12/2014
1Tetraploidy
08/2014
1Muscular Atrophy (Muscle Atrophy)
02/2014
1Atrophy
02/2014
1Pancreatic Neoplasms (Pancreatic Cancer)
04/2013
1Ornithine Carbamoyltransferase Deficiency Disease
01/2011
1Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
08/2010
1Chronic Kidney Failure (Chronic Renal Failure)
07/2009
1Hyperinsulinism (Hyperinsulinemia)
07/2009
1Brain Neoplasms (Brain Tumor)
04/2009
1Hyperphagia
04/2009
1Peutz-Jeghers Syndrome (Polyposis, Hamartomatous Intestinal)
01/2005
1Hamartoma
01/2005

Drug/Important Bio-Agent (IBA)

15Sirolimus (Rapamycin)FDA Link
02/2014 - 09/2006
12Phosphotransferases (Kinase)IBA
06/2015 - 04/2003
7Glucose (Dextrose)FDA LinkGeneric
12/2015 - 09/2008
5Carbon MonoxideIBA
12/2015 - 02/2011
4Histones (Histone)IBA
04/2015 - 01/2011
4Transcription Factors (Transcription Factor)IBA
02/2015 - 10/2003
4Proteins (Proteins, Gene)IBA
02/2015 - 09/2002
4OxygenIBA
02/2014 - 04/2009
4Long-Acting Thyroid Stimulator (LATS)IBA
07/2012 - 11/2007
3DNA (Deoxyribonucleic Acid)IBA
12/2015 - 06/2012
3AMP-Activated Protein KinasesIBA
11/2014 - 11/2003
3EnzymesIBA
01/2014 - 02/2011
2netrin-1IBA
06/2015 - 08/2012
2Protein Kinases (Protein Kinase)IBA
06/2015 - 03/2011
2GTP-Binding Proteins (G-Protein)IBA
05/2015 - 06/2014
2Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA
04/2015 - 03/2013
2DioxygenasesIBA
04/2015 - 06/2012
2Succinic Acid (Succinate)IBA
04/2015 - 06/2012
2UbiquitinIBA
02/2014 - 07/2012
2Lactic AcidFDA LinkGeneric
01/2014 - 04/2013
2isocitric acid (isocitrate)IBA
10/2012 - 04/2009
2Peptide Initiation Factors (Initiation Factor)IBA
08/2010 - 01/2005
1Lomustine (CCNU)FDA Link
12/2015
1Alkylating AgentsIBA
12/2015
1Procarbazine (Matulane)FDA Link
12/2015
1Vincristine (Oncovin)FDA LinkGeneric
12/2015
1Laminin (Merosin)IBA
06/2015
1Estrogens (Estrogen)FDA Link
05/2015
1malic acid (malate)IBA
04/2015
1NAD (NADH)IBA
04/2015
1Aspartic Acid (Aspartate)FDA Link
04/2015
1corrigendumIBA
04/2015
1InterleukinsIBA
03/2015
1Insulin ReceptorIBA
01/2015
1Aldehyde DehydrogenaseIBA
12/2014
1aldehyde dehydrogenase 1IBA
12/2014
1NADP (NADPH)IBA
07/2014
1verteporfin (Visudyne)FDA Link
06/2014
1Uveal melanomaIBA
06/2014
1LigasesIBA
02/2014
1Histone Deacetylases (Histone Deacetylase)IBA
02/2014
1Protein Isoforms (Isoforms)IBA
02/2014
1MyogeninIBA
02/2014
1Glutamine (L-Glutamine)FDA Link
02/2014
1NocodazoleIBA
12/2013
1Epidermal Growth Factor (EGF)IBA
11/2013
1Staphylococcal Protein A (A, Protein)IBA
11/2013
1ATP Citrate (pro-S)-Lyase (Citrate Synthase, ATP)IBA
08/2013
1lactate dehydrogenase 5IBA
04/2013
1Pyruvic Acid (Pyruvate)IBA
04/2013
1OxidoreductasesIBA
10/2012
1Neurofibromin 2 (Merlin)IBA
09/2012
1Fumarate Hydratase (Fumarase)IBA
06/2012
1Succinate Dehydrogenase (Fumarate Reductase)IBA
06/2012
1Biological Markers (Surrogate Marker)IBA
06/2012
1NexusIBA
01/2012
1Pyruvate KinaseIBA
06/2011
1Orotic AcidIBA
01/2011
1alpha-hydroxyglutarateIBA
01/2011
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
11/2010
1beta-Transducin Repeat-Containing ProteinsIBA
11/2010
1Leptin ReceptorsIBA
07/2009
1alpha-ketoglutaric acid (alpha-ketoglutarate)IBA
04/2009
1Pro-Opiomelanocortin (Proopiomelanocortin)IBA
04/2009
1Glycogen Synthase Kinase 3IBA
09/2008
1GTP Phosphohydrolases (GTPases)IBA
08/2008
1Ribosomal Protein S6 Kinases (S6 Kinase)IBA
01/2005
1Carrier Proteins (Binding Protein)IBA
01/2005
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2005

Therapy/Procedure

1Drug Therapy (Chemotherapy)
12/2015
1Heterologous Transplantation (Xenotransplantation)
12/2014
1Denervation
02/2014
1Therapeutics
01/2012
1Withholding Treatment
04/2009