HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

James S Goydos Selected Research

Riluzole

11/2018Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo.
1/2018A phase II trial of riluzole, an antagonist of metabotropic glutamate receptor 1 (GRM1) signaling, in patients with advanced melanoma.
2/2015Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression.
1/2015Riluzole is a radio-sensitizing agent in an in vivo model of brain metastasis derived from GRM1 expressing human melanoma cells.
5/2014Activation of the glutamate receptor GRM1 enhances angiogenic signaling to drive melanoma progression.
3/2014Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells.
1/2012Non-canonical Smads phosphorylation induced by the glutamate release inhibitor, riluzole, through GSK3 activation in melanoma.
11/2011Glutamatergic pathway targeting in melanoma: single-agent and combinatorial therapies.
4/2011Riluzole enhances ionizing radiation-induced cytotoxicity in human melanoma cells that ectopically express metabotropic glutamate receptor 1 in vitro and in vivo.
9/2010The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells.
For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown:


James S Goydos Research Topics

Disease

41Melanoma (Melanoma, Malignant)
11/2018 - 02/2003
22Neoplasms (Cancer)
11/2018 - 09/2003
11Neoplasm Metastasis (Metastasis)
01/2015 - 09/2003
5Skin Neoplasms (Skin Cancer)
05/2017 - 04/2013
3Carcinogenesis
01/2014 - 10/2008
2Sunburn
05/2017 - 11/2012
2Brain Neoplasms (Brain Tumor)
01/2015 - 04/2011
1Fatigue
01/2018
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
02/2015
1Interdigitating Dendritic Cell Sarcoma
10/2014
1Breast Neoplasms (Breast Cancer)
01/2014
1Noninfiltrating Intraductal Carcinoma (DCIS)
01/2014
1Triple Negative Breast Neoplasms
01/2014
1Disease Progression
08/2010

Drug/Important Bio-Agent (IBA)

13Glutamic Acid (Glutamate)FDA Link
11/2018 - 03/2007
12RiluzoleFDA LinkGeneric
11/2018 - 03/2007
12Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA
01/2018 - 03/2007
8Proteins (Proteins, Gene)FDA Link
11/2018 - 10/2008
7Mitogen-Activated Protein KinasesIBA
05/2014 - 12/2003
6Sunscreening Agents (Sunscreens)IBA
05/2017 - 11/2012
3Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
05/2014 - 12/2008
3Protein Isoforms (Isoforms)IBA
01/2014 - 09/2003
3RNA (Ribonucleic Acid)IBA
11/2012 - 12/2003
3erythromycin propionate-N-acetylcysteinateIBA
08/2011 - 07/2010
3Messenger RNA (mRNA)IBA
08/2010 - 12/2003
2Small Interfering RNA (siRNA)IBA
01/2018 - 07/2010
2Phosphotransferases (Kinase)IBA
05/2016 - 01/2012
2PLX 4720IBA
05/2016 - 11/2011
2RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
04/2016 - 06/2006
2Hormones (Hormone)IBA
06/2014 - 01/2014
2Glutamate Receptors (Glutamate Receptor)IBA
05/2014 - 01/2012
2LigandsIBA
01/2012 - 10/2010
2Cyclic AMP (AMP, Cyclic)IBA
08/2011 - 07/2010
2Heparitin Sulfate (Heparan Sulfate)IBA
08/2011 - 07/2010
2Cyclin D1IBA
12/2008 - 05/2007
2DNA (Deoxyribonucleic Acid)IBA
12/2008 - 03/2005
2Monophenol Monooxygenase (Tyrosinase)IBA
09/2005 - 02/2003
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2003 - 09/2003
1AntiportersIBA
11/2018
1Cystine (L-Cystine)IBA
11/2018
1Amino AcidsFDA Link
11/2018
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
05/2016
1Transcription Factors (Transcription Factor)IBA
05/2016
1tyrosine receptor (receptor, tyrosine)IBA
05/2016
1Interferon alpha-2 (Roferon-A)FDA Link
04/2016
1Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
02/2015
1TOR Serine-Threonine KinasesIBA
02/2015
1API 2IBA
02/2015
1VemurafenibIBA
02/2015
1Sirolimus (Rapamycin)FDA Link
02/2015
1Pharmaceutical PreparationsIBA
02/2015
1AgarIBA
02/2015
1Conditioned Culture MediaIBA
07/2014
1Fibroblast Growth Factors (Fibroblast Growth Factor)IBA
07/2014
1Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
07/2014
1Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
07/2014
1Cholecalciferol (Vitamin D3)FDA Link
06/2014
1Focal Adhesion Protein-Tyrosine KinasesIBA
06/2014
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
05/2014
1metabotropic glutamate receptor type 1IBA
01/2014
1Estrogen ReceptorsIBA
01/2014
1ErbB Receptors (EGF Receptor)IBA
01/2014
1Progesterone Receptors (Progesterone Receptor)IBA
01/2014
1ponasterone AIBA
11/2012
1EcdysoneIBA
11/2012
1Tetracycline (Achromycin)FDA LinkGeneric
11/2012
1Glycogen Synthase Kinase 3IBA
01/2012
1Biological ProductsIBA
01/2012
1AcidsIBA
01/2012
1LectinsIBA
01/2012
1Sorafenib (BAY 43-9006)FDA Link
11/2011
1alvocidib (flavopiridol)IBA
06/2011
1Transforming Growth Factors (Transforming Growth Factor)IBA
06/2011
1U 0126 (UO 126)IBA
06/2011
1Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
05/2011
1Interleukin-10 (Interleukin 10)IBA
05/2011
1CytokinesIBA
05/2011
1Ephrin-B2 (Ephrin B2)IBA
10/2010
1EphB4 ReceptorIBA
10/2010
1Nylons (Nylon)IBA
09/2010
1Matrix Metalloproteinases (MMPs)IBA
08/2010
1matrigelIBA
08/2010
1Cadherins (E-Cadherin)IBA
08/2010
1Transforming Growth Factor beta (TGF-beta)IBA
08/2010
1raf KinasesIBA
12/2008
1tanespimycin (17AAG)IBA
12/2008
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
12/2008
1UbiquitinIBA
10/2008
1Peptides (Polypeptides)IBA
10/2008
1Ligases (Synthetase)IBA
10/2008
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
05/2007
1alpha-methyl-4-carboxyphenylglycineIBA
03/2007
1dopachrome isomeraseIBA
03/2007
1MM 77IBA
06/2006

Therapy/Procedure

8Therapeutics
04/2016 - 12/2003
6Lymph Node Excision (Lymph Node Dissection)
04/2016 - 02/2003
4Protective Clothing
05/2017 - 11/2012
3Radiotherapy
01/2015 - 04/2011
1Drug Therapy (Chemotherapy)
10/2014
1Aftercare (After-Treatment)
04/2011