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Murali Gopalakrishnan Selected Research

2,2- dimethyl- 5- (6- phenylpyridazin- 3- yl)- 5- aza- 2- azoniabicyclo(2.2.1)heptane

1/2008

[3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity alpha7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain.

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Murali Gopalakrishnan Research Topics

Disease

9	Overactive Urinary Bladder (Overactive Bladder) 11/2007 - 10/2002
8	Alzheimer Disease (Alzheimer's Disease) 09/2010 - 06/2007
6	Schizophrenia (Dementia Praecox) 04/2012 - 07/2006
3	Neuroblastoma 12/2011 - 09/2010
3	Pain (Aches) 10/2011 - 11/2006
3	Neuralgia (Stump Neuralgia) 10/2011 - 11/2006
3	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2009 - 01/2008
2	Hyperalgesia 10/2011 - 11/2006
2	Urinary Bladder Neck Obstruction (Bladder Neck Obstruction) 01/2003 - 10/2002
1	Peritonitis 10/2011
1	Inflammation 10/2011
1	Nausea 10/2011
1	Vomiting 10/2011
1	Tauopathies 04/2009
1	Dementia (Dementias) 09/2007
1	Central Nervous System Diseases (CNS Diseases) 07/2006
1	Urologic Diseases (Urinary Tract Disease) 10/2004
1	Hypothermia 01/2004
1	Ataxia (Dyssynergia) 01/2004
1	Seizures (Seizure) 01/2004
1	Prostatic Neoplasms (Prostate Cancer) 06/2003

Drug/Important Bio-Agent (IBA)

8	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 04/2012 - 06/2007
8	Adenosine Triphosphate (ATP)IBA 11/2007 - 10/2002
3	alpha7 nicotinic acetylcholine receptorIBA 09/2010 - 04/2009
3	Potassium Channels (Potassium Channel)IBA 11/2007 - 01/2004
2	5-(2-azetidinylmethoxy)-2-chloropyridineIBA 10/2011 - 10/2011
2	5- (6- (1- azabicyclo(2,2,2)oct- 3- yloxy)pyridazin- 3- yl)- 1H- indoleIBA 09/2010 - 09/2010
2	Cholinergic ReceptorsIBA 08/2009 - 07/2009
2	LigandsIBA 08/2008 - 11/2006
2	Amyloid (Amyloid Fibrils)IBA 08/2008 - 06/2007
2	dicyandiamido (cyanoguanidine)IBA 11/2007 - 01/2004
2	9- (3- bromo- 4- fluorophenyl)- 2,3,5,6,7,9- hexahydrothieno(3,2- b)quinolin- 8(4H)- one 1,1-dioxideIBA 10/2002 - 10/2002
1	Antipsychotic Agents (Antipsychotics)IBA 04/2012
1	1- (5- chloro- 2,4- dimethoxyphenyl)- 3- (5- methylisoxazol- 3- yl)ureaIBA 12/2011
1	CalciumIBA 12/2011
1	ZymosanIBA 10/2011
1	CytokinesIBA 10/2011
1	Acetylcholine (Acetylcholine Chloride)FDA Link 10/2011
1	CarrageenanIBA 10/2011
1	Carbon MonoxideIBA 10/2011
1	Ligand-Gated Ion ChannelsIBA 08/2009
1	glycogen synthase kinase 3 betaIBA 04/2009
1	GTP-Binding Proteins (G-Protein)IBA 01/2009
1	amyloid beta-protein (1-42)IBA 08/2008
1	2,2- dimethyl- 5- (6- phenylpyridazin- 3- yl)- 5- aza- 2- azoniabicyclo(2.2.1)heptaneIBA 01/2008
1	pregabalin (Lyrica)FDA Link 11/2006
1	Analgesics (Analgesic Drugs)IBA 11/2006
1	Calcium Channels (Calcium Channel)IBA 11/2006
1	gabapentin (Neurontin)FDA LinkGeneric 11/2006
1	Nicotine FDA Link 07/2006
1	A-151892IBA 09/2004
1	2- methyl- 3- (2- pyrrolidinylmethoxy)pyridineIBA 01/2004
1	1-ethyl-2-benzimidazolinoneIBA 06/2003
1	Riluzole FDA LinkGeneric 06/2003
1	RubidiumIBA 06/2003
1	tolterodine (Detrol)FDA Link 01/2003
1	1,4-dihydropyridine (dihydropyridine)IBA 10/2002
1	PotassiumIBA 10/2002

Therapy/Procedure

1	Oral Administration 10/2011
1	Ligation 11/2006
1	Therapeutics 01/2003