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Kent S Gates Selected Research

tirapazamine (SR 4233)

8/2014Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
3/2012On the reaction mechanism of tirapazamine reduction chemistry: unimolecular N-OH homolysis, stepwise dehydration, or triazene ring-opening.
1/2012DNA strand cleavage by the phenazine di-N-oxide natural product myxin under both aerobic and anaerobic conditions.
5/2010DNA strand cleaving properties and hypoxia-selective cytotoxicity of 7-chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-dioxide.
1/2009Initiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxide.
10/2007DNA strand damage product analysis provides evidence that the tumor cell-specific cytotoxin tirapazamine produces hydroxyl radical and acts as a surrogate for O(2).
11/2004Enzyme-activated, hypoxia-selective DNA damage by 3-amino-2-quinoxalinecarbonitrile 1,4-di-N-oxide.
9/2003DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
9/2002Oxidative DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).

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Kent S Gates Research Topics

Disease

12Neoplasms (Cancer)
03/2015 - 09/2002
10Anoxia (Hypoxia)
08/2014 - 09/2003
1Dehydration (Water Stress)
03/2012
1Colorectal Neoplasms (Colorectal Cancer)
01/2012

Drug/Important Bio-Agent (IBA)

9tirapazamine (SR 4233)IBA
08/2014 - 09/2002
8DNA (Deoxyribonucleic Acid)IBA
08/2014 - 09/2002
7OxygenIBA
08/2014 - 11/2004
33-amino-1,2,4-benzotriazineIBA
08/2014 - 10/2007
2OxidoreductasesIBA
03/2015 - 04/2013
2leinamycin (DC 107)IBA
01/2013 - 05/2008
2Antineoplastic Agents (Antineoplastics)IBA
01/2012 - 05/2008
1Alkylating AgentsIBA
08/2014
1NitrogenIBA
08/2014
1ProdrugsIBA
04/2013
1cinnolineIBA
04/2012
16-aminoquinolineIBA
04/2012
1hydroxide ionIBA
03/2012
1myxinIBA
01/2012
1Cyclic N-Oxides (Oxides, Cyclic N)IBA
01/2012
1Transcription Factors (Transcription Factor)IBA
08/2010
1Protein Tyrosine PhosphatasesIBA
08/2010
1Proteins (Proteins, Gene)IBA
08/2010
1oltiprazIBA
08/2010
17- chloro- 2- thienylcarbonyl- 3- trifluoromethylquinoxaline 1,4-dioxideIBA
05/2010
1S-deoxyleinamycinIBA
05/2008
1Hydroxyl RadicalIBA
10/2007
13-amino-2-quinoxalinecarbonitrile 1,4-di-N-oxideIBA
11/2004
13-amino-2-quinoxalinecarbonitrileIBA
11/2004