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Henry S Friedman Selected Research

irinotecan (Camptosar)

7/2015Phase II Trial of Upfront Bevacizumab, Irinotecan, and Temozolomide for Unresectable Glioblastoma.
1/2014Efficacy of bevacizumab plus irinotecan in children with recurrent low-grade gliomas--a Pediatric Brain Tumor Consortium study.
12/2013Bevacizumab (BVZ)-associated toxicities in children with recurrent central nervous system tumors treated with BVZ and irinotecan (CPT-11): a Pediatric Brain Tumor Consortium Study (PBTC-022).
11/2012Lack of efficacy of bevacizumab + irinotecan in cases of pediatric recurrent ependymoma--a Pediatric Brain Tumor Consortium study.
3/2012Phase II study of carboplatin, irinotecan, and bevacizumab for bevacizumab naïve, recurrent glioblastoma.
1/2012Addition of bevacizumab to standard radiation therapy and daily temozolomide is associated with minimal toxicity in newly diagnosed glioblastoma multiforme.
12/2011Phase I study of sunitinib and irinotecan for patients with recurrent malignant glioma.
12/2011Phase 2 study of carboplatin, irinotecan, and bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy.
6/2011The addition of bevacizumab to standard radiation therapy and temozolomide followed by bevacizumab, temozolomide, and irinotecan for newly diagnosed glioblastoma.
6/2010Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: a Pediatric Brain Tumor Consortium study.
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Henry S Friedman Research Topics

Disease

81Neoplasms (Cancer)
04/2015 - 01/2002
69Glioma (Gliomas)
12/2014 - 04/2002
52Glioblastoma (Glioblastoma Multiforme)
07/2015 - 06/2002
30Brain Neoplasms (Brain Tumor)
07/2014 - 04/2002
12Melanoma (Melanoma, Malignant)
09/2011 - 01/2002
10Medulloblastoma
03/2009 - 01/2002
7Astrocytoma (Pilocytic Astrocytoma)
10/2011 - 04/2002
6Anoxia (Hypoxia)
01/2014 - 01/2008
4Ependymoma
04/2015 - 04/2002
4Diarrhea
07/2012 - 01/2004
4Fatigue
07/2012 - 10/2009
3Infection
11/2014 - 02/2009
3Rhabdomyosarcoma
11/2005 - 07/2002
2Vomiting
07/2014 - 03/2006
2Central Nervous System Neoplasms
12/2013 - 07/2007
2Meningioma (Meningiomas)
08/2012 - 01/2012
2Lymphopenia (Lymphocytopenia)
09/2011 - 03/2011
2Hypersensitivity (Allergy)
03/2011 - 11/2010
2Neutropenia
10/2009 - 02/2009
2Colorectal Neoplasms (Colorectal Cancer)
02/2009 - 02/2008
2Breast Neoplasms (Breast Cancer)
11/2008 - 11/2003
2Weight Loss (Weight Reduction)
07/2007 - 09/2006
2Meningitis
03/2006 - 10/2002
2Neuroblastoma
10/2004 - 09/2002
2Disease Progression
07/2002 - 04/2002
1Tetanus
03/2015
1Diphtheria
03/2015
1Ovarian Neoplasms (Ovarian Cancer)
12/2014
1Poliomyelitis (Polio)
11/2014
1Nausea
07/2014

Drug/Important Bio-Agent (IBA)

39temozolomide (Temodar)FDA LinkGeneric
07/2015 - 09/2002
33bevacizumabFDA Link
07/2015 - 02/2007
28irinotecan (Camptosar)FDA LinkGeneric
07/2015 - 04/2002
22Epidermal Growth Factor Receptor (EGF Receptor)IBA
12/2014 - 01/2002
13Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2014 - 09/2006
12Carmustine (FIVB)FDA Link
08/2009 - 05/2002
11Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
07/2012 - 11/2002
10Phosphotransferases (Kinase)IBA
07/2012 - 12/2004
10epidermal growth factor receptor VIIIIBA
01/2012 - 01/2002
10O(6)-benzylguanineIBA
10/2009 - 05/2002
8Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
01/2014 - 11/2005
7DNA (Deoxyribonucleic Acid)IBA
11/2010 - 09/2002
6imatinib (Gleevec)FDA Link
10/2012 - 12/2005
6Type I DNA Topoisomerases (Topoisomerase I)IBA
02/2009 - 09/2002
5Hydroxyurea (Hydrea)FDA LinkGeneric
10/2012 - 12/2005
5Sirolimus (Rapamycin)FDA Link
10/2011 - 01/2005
5tyrosine receptor (receptor, tyrosine)IBA
01/2010 - 01/2005
5Melphalan (Alkeran)FDA LinkGeneric
05/2007 - 08/2004
4AntigensIBA
04/2015 - 01/2002
4VaccinesIBA
04/2015 - 05/2008
4O(6)-Methylguanine-DNA MethyltransferaseIBA
12/2009 - 05/2002
4gefitinib (Iressa)FDA Link
02/2006 - 11/2002
3Proteins (Proteins, Gene)IBA
12/2014 - 10/2011
3Carbonic Anhydrases (Carbonic Anhydrase)IBA
01/2014 - 01/2008
3erlotinib (CP 358,774)FDA Link
07/2012 - 01/2010
3Carboplatin (JM8)FDA LinkGeneric
03/2012 - 07/2002
3everolimusFDA Link
10/2011 - 01/2005
3Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
01/2011 - 01/2005
3laromustine (VNP40101M)IBA
02/2008 - 01/2007
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
12/2007 - 01/2002
3Glutathione (Reduced Glutathione)IBA
05/2007 - 08/2004
2RNA (Ribonucleic Acid)IBA
04/2015 - 03/2015
2Protein Kinases (Protein Kinase)IBA
12/2014 - 09/2007
27- chloro- 8- hydroxy- 1- (3'- iodophenyl)- 3- methyl- 2,3,4,5- tetrahydro- 1H- 3- benzazepine (TISCH)IBA
07/2014 - 01/2007
2Tyrosine (L-Tyrosine)FDA Link
06/2012 - 06/2007
2AEE 788 (AEE788)IBA
06/2012 - 01/2005
2Anticonvulsants (Antiepileptic Drugs)IBA
06/2012 - 02/2006
2TransferasesIBA
12/2011 - 04/2006
2Etoposide (VP 16)FDA LinkGeneric
06/2011 - 04/2006
2INO 1001IBA
08/2010 - 09/2005
2decanedioic acid- 4,4'- (1,3- propanediylbis(oxy))bis(benzoic acid) copolymer (Gliadel)FDA Link
02/2009 - 10/2007
2Monoclonal AntibodiesIBA
05/2008 - 10/2002
2Adenosine Triphosphate (ATP)IBA
05/2007 - 12/2005
2Ribonucleotide Reductases (Ribonucleotide Reductase)IBA
05/2007 - 12/2005
2Glutathione Transferase (Glutathione S-Transferase)IBA
05/2007 - 09/2004
2Transforming Growth Factor alpha (TGF-alpha)IBA
01/2005 - 10/2003
2transforming growth factor(alpha)-Pseudomonas aeruginosa exotoxin (38)IBA
01/2005 - 10/2003
2keyhole-limpet hemocyanin (keyhole limpet hemocyanin)IBA
09/2003 - 01/2002
1Combined VaccinesIBA
04/2015
1Biological Markers (Surrogate Marker)IBA
04/2015
1Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
04/2015
1Tetanus Toxoid (Vaccine, Tetanus)FDA Link
03/2015
1cytomegalovirus matrix protein 65kDaIBA
03/2015
1Heat-Shock Proteins (Heat-Shock Protein)IBA
12/2014
117-(allylamino)-17-demethoxygeldanamycin (17AAG)IBA
12/2014
1Messenger RNA (mRNA)IBA
12/2014
1palonosetron (Aloxi)FDA Link
07/2014
1Dexamethasone (Maxidex)FDA LinkGeneric
07/2014

Therapy/Procedure

30Drug Therapy (Chemotherapy)
07/2015 - 04/2002
26Heterologous Transplantation (Xenotransplantation)
12/2014 - 04/2002
11Radiotherapy
12/2009 - 04/2002
6Immunotherapy
11/2014 - 05/2008
5Salvage Therapy
03/2012 - 04/2006
3Radioimmunotherapy
05/2007 - 01/2005
2Therapeutics
04/2011 - 05/2004
2Catheters
08/2010 - 02/2007
2Aftercare (After-Treatment)
07/2007 - 05/2004
2Brachytherapy
05/2007 - 01/2006
1Oncolytic Virotherapy
11/2014
1Premedication
07/2014