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Felix J Frey Selected Research

11-beta-Hydroxysteroid Dehydrogenase Type 2 (11 beta-Hydroxysteroid Dehydrogenase Type 2)

1/2014Insulin, CCAAT/enhancer-binding proteins and lactate regulate the human 11β-hydroxysteroid dehydrogenase type 2 gene expression in colon cancer cell lines.
6/2008Age-dependent decrease in 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) activity in hypertensive patients.
11/2007Identification of polymorphisms in the human 11beta-hydroxysteroid dehydrogenase type 2 gene promoter: functional characterization and relevance for salt sensitivity.
4/2007Impaired protein stability of 11beta-hydroxysteroid dehydrogenase type 2: a novel mechanism of apparent mineralocorticoid excess.
1/2006Analbuminemic Nagase rats: blood pressure response to dietary salt challenge.
12/2005Extracellular ATP determines 11beta-hydroxysteroid dehydrogenase type 2 activity via purinergic receptors.
7/2004Glucocorticoid-mediated mineralocorticoid receptor activation and hypertension.
2/2004The 11-ketosteroid 11-ketodexamethasone is a glucocorticoid receptor agonist.
9/2003Angiotensin II regulates 11beta-hydroxysteroid dehydrogenase type 2 via AT2 receptors.
5/2003Hypoxia causes down-regulation of 11 beta-hydroxysteroid dehydrogenase type 2 by induction of Egr-1.

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Felix J Frey Research Topics

Disease

18Hypertension (High Blood Pressure)
10/2014 - 01/2002
7Pre-Eclampsia (Preeclampsia)
11/2013 - 09/2003
4Neoplasms (Cancer)
03/2015 - 02/2004
4Acute Kidney Injury (Acute Renal Failure)
04/2014 - 08/2005
4Edema
10/2006 - 01/2005
3Prostatic Neoplasms (Prostate Cancer)
03/2015 - 06/2011
3Inflammation
03/2010 - 12/2005
3Chronic Kidney Failure (Chronic Renal Failure)
08/2009 - 04/2002
3Anoxia (Hypoxia)
10/2005 - 05/2003
3Liver Cirrhosis (Hepatic Cirrhosis)
09/2005 - 07/2002
3Nephrotic Syndrome (Syndrome, Nephrotic)
01/2005 - 05/2002
3Hyperaldosteronism (Conn Syndrome)
02/2004 - 05/2002
2Body Weight (Weight, Body)
01/2011 - 10/2008
2Renal Insufficiency (Renal Failure)
08/2009 - 05/2002
2Obesity
02/2009 - 01/2008
2Hypercalciuria
08/2008 - 06/2008
2Hyperparathyroidism
08/2007 - 07/2005
2Ascites
10/2006 - 06/2005
2Ischemia
12/2005 - 05/2003
2Glomerulonephritis
11/2003 - 01/2002
1Arteriovenous Fistula
08/2015
1Conductive Hearing Loss
08/2015
1Atherosclerosis
03/2014
1Colonic Neoplasms (Colon Cancer)
01/2014
1Systemic Lupus Erythematosus (Libman-Sacks Disease)
05/2012
1Inappropriate ADH Syndrome (SIADH)
11/2009
1Wasting Syndrome (Wasting Disease)
11/2009
1Hyperkalemia
10/2009
1Aortic Valve Stenosis (Aortic Stenosis)
07/2009
1Calciphylaxis
12/2008

Drug/Important Bio-Agent (IBA)

10AldosteroneIBA
02/2014 - 05/2002
1011-beta-Hydroxysteroid Dehydrogenase Type 2 (11 beta-Hydroxysteroid Dehydrogenase Type 2)IBA
01/2014 - 05/2003
10SodiumIBA
01/2014 - 01/2002
8Hydrocortisone (Cortisol)FDA LinkGeneric
01/2011 - 01/2002
7Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA
06/2009 - 04/2002
6CalciumIBA
12/2008 - 10/2002
5PotassiumIBA
10/2006 - 01/2002
4Aldosterone Synthase (CYP11B2)IBA
06/2009 - 06/2003
3ReninIBA
04/2007 - 05/2002
3CortisoneIBA
04/2007 - 01/2002
311-beta-Hydroxysteroid Dehydrogenases (11beta Hydroxysteroid Dehydrogenase)IBA
10/2006 - 05/2002
3CreatinineIBA
07/2005 - 01/2002
3Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
11/2003 - 01/2002
2Carbon MonoxideIBA
03/2015 - 06/2005
2Androgen Receptors (Androgen Receptor)IBA
03/2015 - 06/2011
2Lactic AcidFDA LinkGeneric
01/2014 - 10/2005
2OxidoreductasesIBA
01/2014 - 12/2004
2Apparent mineralocorticoid excessIBA
01/2014 - 04/2007
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2013 - 10/2005
2Prostate-Specific Antigen (Semenogelase)IBA
12/2011 - 06/2011
2Spironolactone (Aldactone)FDA LinkGeneric
01/2011 - 07/2004
2Immunoglobulins (Immunoglobulin)IBA
03/2010 - 07/2005
2HormonesIBA
11/2009 - 07/2004
211-beta-Hydroxysteroid Dehydrogenase Type 1IBA
02/2009 - 07/2004
2EnzymesIBA
01/2008 - 06/2005
2cinacalcet (Sensipar)FDA Link
08/2007 - 07/2005
2Puromycin AminonucleosideIBA
01/2005 - 05/2002
2Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)IBA
12/2004 - 02/2004
2Angiotensin IIIBA
07/2004 - 09/2003
1MicroRNAs (MicroRNA)IBA
10/2014
1insulin-like growth factor binding protein-related protein 1IBA
04/2014
1Apolipoproteins E (ApoE)IBA
03/2014
1CholesterolIBA
03/2014
1CCAAT-Enhancer-Binding ProteinsIBA
01/2014
1Insulin (Novolin)FDA Link
01/2014
1Tyrosine (L-Tyrosine)FDA Link
05/2013
1Procainamide (Procan)FDA LinkGeneric
05/2012
1dimethylaniline monooxygenase (N-oxide forming) (flavin-containing monooxygenase)IBA
05/2012
1Gentian Violet (Violet, Crystal)FDA Link
12/2011
1Androgen Antagonists (Antiandrogens)IBA
12/2011
1(3- dimyristyloxypropyl)(dimethyl)(hydroxyethyl)ammoniumIBA
06/2011
1Diphtheria ToxinIBA
06/2011
1ZincIBA
03/2010
1Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA
03/2010
1AdrenomedullinIBA
03/2010
1Mannose-Binding Lectin (Mannan-Binding Lectin)IBA
03/2010
1UromodulinIBA
03/2010
1ProteomeIBA
03/2010
1Carrier Proteins (Binding Protein)IBA
03/2010
1Leucine (L-Leucine)FDA Link
03/2010
1Vitamin A (Retinol)FDA LinkGeneric
03/2010
1Proteins (Proteins, Gene)IBA
03/2010
1Glycoproteins (Glycoprotein)IBA
03/2010
1Serine Proteases (Serine Protease)IBA
03/2010
1Brain Natriuretic Peptide (Natrecor)FDA Link
11/2009
1Atrial Natriuretic Factor (ANF)IBA
11/2009
1CalcineurinIBA
08/2009

Therapy/Procedure

3Transplants (Transplant)
08/2015 - 07/2002
3Renal Replacement Therapy (Therapies, Renal Replacement)
08/2009 - 08/2005
2Heterologous Transplantation (Xenotransplantation)
03/2015 - 06/2011
2Renal Dialysis (Hemodialysis)
10/2009 - 01/2002
2Homologous Transplantation (Allograft)
08/2007 - 10/2002
2Transplantation (Transplant Recipients)
08/2007 - 07/2005
1Hearing Aids (Hearing Aid)
08/2015
1Catheters
08/2015
1Castration
12/2011
1Cardiopulmonary Bypass (Heart-Lung Bypass)
03/2010
1Extracorporeal Circulation
03/2010
1Liver Transplantation
08/2009
1Surgical Instruments (Clip)
07/2009