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William D Figg Selected Research

romidepsin (FK228)

8/2013Phase I trial of a new schedule of romidepsin in patients with advanced cancers.
6/2013Electrocardiographic studies of romidepsin demonstrate its safety and identify a potential role for K(ATP) channel.
6/2011Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma.
7/2010Romidepsin: a new therapy for cutaneous T-cell lymphoma and a potential therapy for solid tumors.
1/2010Laboratory correlates for a phase II trial of romidepsin in cutaneous and peripheral T-cell lymphoma.
11/2009Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma.
2/2009Population pharmacokinetics of romidepsin in patients with cutaneous T-cell lymphoma and relapsed peripheral T-cell lymphoma.
1/2008Clinical and molecular responses in lung cancer patients receiving Romidepsin.
9/2004Determination of the cyclic depsipeptide FK228, a histone deacetylase inhibitor, by liquid chromatography-mass spectrometry.
11/2002A phase I trial of depsipeptide (FR901228) in patients with advanced cancer.
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William D Figg Research Topics

Disease

143Neoplasms (Cancer)
04/2015 - 01/2002
126Prostatic Neoplasms (Prostate Cancer)
10/2015 - 01/2002
19Neoplasm Metastasis (Metastasis)
11/2013 - 01/2002
12Breast Neoplasms (Breast Cancer)
01/2014 - 02/2003
9Anoxia (Hypoxia)
06/2015 - 09/2003
9Disease Progression
12/2014 - 05/2005
9Neutropenia
11/2014 - 05/2002
7Renal Cell Carcinoma (Grawitz Tumor)
01/2015 - 07/2004
7Multiple Myeloma
11/2014 - 11/2004
6Lymphoma (Lymphomas)
11/2014 - 06/2005
6Fatigue
06/2013 - 03/2002
5Carcinoma (Carcinomatosis)
01/2015 - 10/2003
5Diarrhea
11/2014 - 02/2003
5T-Cell Lymphoma (Lymphoma, T Cell)
08/2013 - 02/2009
4Hypertension (High Blood Pressure)
12/2014 - 02/2009
4Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral)
06/2013 - 02/2009
4Pain (Aches)
10/2007 - 02/2003
3Ovarian Neoplasms (Ovarian Cancer)
01/2015 - 08/2008
3Hepatocellular Carcinoma (Hepatoma)
12/2014 - 08/2011
3Glioblastoma (Glioblastoma Multiforme)
12/2014 - 12/2013
3Thrombocytopenia (Thrombopenia)
11/2014 - 05/2005
3Osteonecrosis (Kienbock's Disease)
01/2012 - 02/2009
3Lung Neoplasms (Lung Cancer)
02/2011 - 04/2002
3Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous)
07/2010 - 02/2009
3Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
05/2010 - 09/2007
3Hematologic Neoplasms (Hematological Malignancy)
06/2009 - 06/2007
3Peripheral Nervous System Diseases (PNS Diseases)
07/2008 - 04/2006
3Glioma (Gliomas)
12/2007 - 06/2003
2Colorectal Neoplasms (Colorectal Cancer)
09/2015 - 11/2004
2Melanoma (Melanoma, Malignant)
01/2015 - 06/2007
2Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
11/2014 - 05/2011
2Nausea
11/2014 - 03/2002
2Hypersensitivity (Allergy)
05/2014 - 06/2005

Drug/Important Bio-Agent (IBA)

29Thalidomide (Thalomid)FDA Link
04/2010 - 02/2002
27docetaxel (Taxotere)FDA Link
01/2014 - 01/2003
22Androgen Receptors (Androgen Receptor)IBA
06/2015 - 01/2002
17HormonesIBA
10/2014 - 05/2002
17Prostate-Specific Antigen (Semenogelase)IBA
06/2014 - 09/2002
14VA 061 (VA061)IBA
12/2008 - 01/2003
13Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2014 - 01/2002
13Histone Deacetylase InhibitorsIBA
11/2014 - 03/2002
12Paclitaxel (Taxol)FDA LinkGeneric
02/2012 - 04/2002
11bevacizumabFDA Link
12/2014 - 08/2008
11romidepsin (FK228)FDA Link
08/2013 - 03/2002
10sorafenib (BAY 43-9006)FDA Link
09/2015 - 10/2006
10Testosterone (Sustanon)FDA Link
12/2012 - 03/2006
9Finasteride (Propecia)FDA LinkGeneric
03/2015 - 04/2008
9flavopiridolIBA
01/2015 - 05/2002
9lenalidomide (CC 5013)FDA Link
08/2014 - 05/2002
8Transcription Factors (Transcription Factor)IBA
04/2015 - 09/2003
7Prednisone (Sone)FDA LinkGeneric
09/2013 - 02/2009
7DNA (Deoxyribonucleic Acid)IBA
08/2013 - 01/2002
7Angiogenesis InhibitorsIBA
09/2012 - 05/2002
7N- (2- aminophenyl)- 4- (N- (pyridin- 3- ylmethoxycarbonyl)aminomethyl)benzamide (MS 275)IBA
09/2007 - 05/2004
6Proteins (Proteins, Gene)IBA
04/2015 - 02/2003
6Carbon MonoxideIBA
01/2015 - 03/2003
6Estrogens (Estrogen)FDA Link
01/2014 - 12/2003
6Phosphotransferases (Kinase)IBA
12/2013 - 08/2004
6Biological Markers (Surrogate Marker)IBA
12/2013 - 05/2002
5PlatinumIBA
04/2015 - 07/2008
5Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
08/2007 - 10/2005
4Dihydrotestosterone (Androstanolone)IBA
06/2015 - 02/2005
4AndrogensIBA
12/2014 - 02/2005
4P-GlycoproteinIBA
02/2011 - 07/2004
4EndostatinsIBA
09/2009 - 05/2002
4Matrix MetalloproteinasesIBA
06/2004 - 01/2002
3imatinib (Gleevec)FDA Link
06/2015 - 08/2006
3satraplatin (JM 216)IBA
04/2015 - 09/2013
3Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
01/2015 - 06/2013
3Interleukin-15 (Interleukin 15)IBA
01/2015 - 05/2011
3EnzymesIBA
12/2014 - 06/2002
3Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
12/2014 - 08/2004
3bortezomib (Velcade)FDA Link
11/2014 - 05/2011
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
11/2014 - 12/2004
3CytochromesIBA
01/2014 - 10/2005
37-hydroxystaurosporine (UCN 01)IBA
12/2011 - 10/2004
3Vinblastine (Vinblastine Sulfate)FDA Link
11/2010 - 01/2003
3Ketoconazole (Nizoral)FDA LinkGeneric
06/2010 - 12/2002
3cytochrome P-450 CYP1B1 (CYP1B1)IBA
01/2010 - 03/2006
3ATP-Binding Cassette Transporters (ABC Transporters)IBA
02/2007 - 04/2003
3albumin-bound paclitaxelFDA Link
07/2006 - 06/2005
3CytotoxinsIBA
12/2004 - 06/2003
2OxygenIBA
04/2015 - 11/2005
2Hypoxia-Inducible Factor 1IBA
04/2015 - 08/2011
24- ((4- Fluoro- 2- methyl- 1H- indol- 5- yl)oxy)- 6- methoxy- 7- (3- (pyrrolidin- 1- yl)propoxy)quinazoline (AZD2171)IBA
01/2015 - 06/2013
2Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
01/2015 - 07/2008
2Interleukin-2 (IL2)IBA
12/2014 - 05/2011
2Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA
12/2014 - 08/2007
2D 21266 (perifosine)IBA
11/2014 - 10/2005
2Doxorubicin (Adriamycin)FDA LinkGeneric
11/2014 - 06/2007
2Proto-Oncogene Proteins c-etsIBA
10/2014 - 03/2006
2HIV ProteaseIBA
09/2014 - 09/2007
2Nelfinavir (Viracept)FDA Link
09/2014 - 09/2007
2AntigensIBA
05/2014 - 10/2006
2pomalidomideIBA
04/2014 - 06/2007

Therapy/Procedure

28Castration
10/2015 - 09/2007
23Drug Therapy (Chemotherapy)
10/2014 - 01/2003
16Heterologous Transplantation (Xenotransplantation)
10/2015 - 11/2002
5Radiotherapy
10/2014 - 02/2004
3Therapeutics
01/2012 - 10/2005