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John R Falck Selected Research

Arachidonic Acid (Vitamin F)

7/2015Arachidonic acid monooxygenase: Genetic and biochemical approaches to physiological/pathophysiological relevance.
10/2013Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer.
9/201320-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.
12/2010Epoxyeicosatrienoic acid agonist regulates human mesenchymal stem cell-derived adipocytes through activation of HO-1-pAKT signaling and a decrease in PPARĪ³.
5/2010Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats.
3/2010Intrarenal cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip Goldblatt hypertensive rats.
3/2007Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts.
4/20069L gliosarcoma cell proliferation and tumor growth in rats are suppressed by N-hydroxy-N'-(4-butyl-2-methylphenol) formamidine (HET0016), a selective inhibitor of CYP4A.
2/2006Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection.
10/2005Cytochrome P450 and arachidonic acid metabolites: role in myocardial ischemia/reperfusion injury revisited.
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John R Falck Research Topics

Disease

28Hypertension (High Blood Pressure)
10/2015 - 07/2004
14Ischemia
10/2015 - 10/2004
12Anoxia (Hypoxia)
01/2015 - 08/2002
10Reperfusion Injury
10/2015 - 10/2004
10Inflammation
09/2014 - 10/2005
7Neoplasms (Cancer)
10/2012 - 12/2004
6Myocardial Infarction
10/2015 - 10/2004
5Obesity
10/2014 - 03/2008
5Septic Shock (Toxic Shock Syndrome)
09/2014 - 01/2012
5Hypotension (Low Blood Pressure)
09/2014 - 01/2012
5Cardiovascular Diseases (Cardiovascular Disease)
07/2013 - 05/2005
4Proteinuria
08/2015 - 10/2009
4Body Weight (Weight, Body)
01/2012 - 12/2006
3Hypertrophy
03/2015 - 05/2010
3Tachycardia (Tachyarrhythmias)
09/2014 - 04/2013
3Breast Neoplasms (Breast Cancer)
10/2013 - 05/2011
3Myocardial Ischemia (Ischemic Heart Diseases)
01/2008 - 10/2004
2Fibrosis (Cirrhosis)
01/2015 - 11/2013
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2014 - 09/2011
2Corneal Neovascularization
08/2013 - 10/2005
2Wounds and Injuries (Trauma)
01/2013 - 12/2011
2Neoplasm Metastasis (Metastasis)
01/2012 - 09/2011
2Carcinoma (Carcinomatosis)
12/2010 - 09/2007
2Glioma (Gliomas)
10/2008 - 11/2005
2Hyperemia
08/2008 - 08/2005
2Infarction
02/2008 - 03/2007
2Pulmonary Hypertension (Ayerza Syndrome)
04/2006 - 08/2005
1Diabetic Nephropathies (Diabetic Nephropathy)
03/2015
1Renal Hypertension
03/2015
1Albuminuria
03/2015
1Heart Failure
01/2015

Drug/Important Bio-Agent (IBA)

4320-hydroxy-5,8,11,14-eicosatetraenoic acidIBA
10/2015 - 08/2002
26Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
03/2015 - 07/2004
16AcidsIBA
07/2015 - 08/2005
12Arachidonic Acid (Vitamin F)IBA
07/2015 - 07/2004
8Alkane 1-Monooxygenase (Alkane 1 Monooxygenase)IBA
10/2015 - 07/2004
7Epoxide HydrolasesIBA
04/2013 - 04/2005
6SodiumIBA
07/2015 - 06/2006
6Hydroxyeicosatetraenoic Acids (HETE)IBA
03/2014 - 04/2005
5Angiotensin IIIBA
10/2014 - 05/2010
5Glycine (Aminoacetic Acid)FDA LinkGeneric
09/2014 - 03/2009
5N- methylsulfonyl- 6- (2- propargyloxyphenyl)hexanamideIBA
01/2014 - 12/2004
5EicosanoidsIBA
10/2013 - 07/2007
511,12-epoxy-5,8,14-eicosatrienoic acidIBA
06/2010 - 12/2005
414,15-epoxy-5,8,11-eicosatrienoic acidIBA
10/2015 - 10/2005
4Mixed Function Oxygenases (Monooxygenases)IBA
07/2015 - 12/2004
4cytochrome P-450 CYP2C subfamilyIBA
07/2015 - 06/2007
4Acetylcholine (Acetylcholine Chloride)FDA Link
01/2014 - 07/2005
4Messenger RNA (mRNA)IBA
10/2012 - 12/2005
4Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2012 - 08/2002
3CytochromesIBA
10/2014 - 10/2004
3N-(20-hydroxyeicosa-5,14-dienoyl)glycineIBA
09/2014 - 04/2013
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
03/2014 - 09/2011
3EnzymesIBA
10/2013 - 04/2005
3Epoprostenol (Prostacyclin)FDA LinkGeneric
07/2013 - 07/2005
3ProstaglandinsIBA
07/2013 - 07/2005
3AngiotensinsIBA
08/2012 - 01/2010
3formamidine (formamidinium)IBA
03/2009 - 11/2005
3Adenosine Triphosphate (ATP)IBA
03/2007 - 08/2002
3DDMSIBA
02/2006 - 10/2004
2CreatinineIBA
10/2015 - 10/2009
2Nitric Oxide Synthase (NO Synthase)IBA
08/2015 - 08/2002
2Lisinopril (Prinivil)FDA LinkGeneric
07/2015 - 01/2015
2Proteins (Proteins, Gene)IBA
07/2015 - 12/2010
2Losartan (Cozaar)FDA LinkGeneric
07/2015 - 01/2015
2Doxycycline (Vibramycin)FDA LinkGeneric
07/2015 - 07/2013
2AdiponectinIBA
01/2015 - 12/2009
2Epithelial Sodium ChannelIBA
10/2014 - 06/2006
2Phosphotransferases (Kinase)IBA
09/2014 - 04/2011
2LigandsIBA
01/2014 - 06/2007
2Peroxynitrous Acid (Peroxynitrite)IBA
09/2013 - 07/2013
2Retinaldehyde (Retinal)IBA
08/2013 - 03/2008
2Type 1 Angiotensin ReceptorIBA
08/2012 - 11/2010
2Insulin (Novolin)FDA Link
01/2012 - 12/2009
2CytokinesIBA
01/2012 - 01/2012
2OxygenIBA
01/2012 - 12/2009
2cytochrome P-450 CYP4A2 (rat)IBA
11/2010 - 10/2009
2ReninIBA
05/2010 - 12/2009
2Antisense OligonucleotidesIBA
03/2008 - 12/2005
2caproamideIBA
12/2007 - 04/2006
22-arachidonylglycerol (2-arachidonoylglycerol)IBA
09/2007 - 12/2004
28,9-epoxyeicosatrienoic acidIBA
03/2007 - 08/2005
2HMR 1098IBA
03/2007 - 12/2004
2cytochrome P-450 omega-hydroxylaseIBA
02/2006 - 12/2004
2glucuronyl glucosamine glycan sulfate (Vessel)IBA
10/2005 - 08/2002
2Miconazole (Monistat)FDA LinkGeneric
12/2004 - 10/2004
1Endothelial Growth FactorsIBA
08/2015
1midkineIBA
08/2015
1Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
07/2015
1Angiotensin Receptors (Angiotensin II Receptor)IBA
07/2015
1Tetracycline (Achromycin)FDA LinkGeneric
07/2015
1Streptozocin (Streptozotocin)FDA Link
03/2015
1AngiotensinogenIBA
01/2015
1tin mesoporphyrinIBA
01/2015
1Myeloid Differentiation Factor 88IBA
09/2014
1Transforming Growth Factors (Transforming Growth Factor)IBA
09/2014
1MicroRNAs (MicroRNA)IBA
09/2014

Therapy/Procedure

3Surgical Instruments (Clip)
10/2015 - 12/2009
3Heterologous Transplantation (Xenotransplantation)
10/2013 - 09/2011
1Ligation
01/2015