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William E Evans Selected Research

Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)

10/2015Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia.
7/2015Genome-wide analysis links NFATC2 with asparaginase hypersensitivity.
6/2015Systemic Exposure to Thiopurines and Risk of Relapse in Children With Acute Lymphoblastic Leukemia: A Children's Oncology Group Study.
6/2015NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells.
4/2015Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.
2/2015Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia.
1/2015Antileukemic Efficacy of Continuous vs Discontinuous Dexamethasone in Murine Models of Acute Lymphoblastic Leukemia.
10/20146MP adherence in a multiracial cohort of children with acute lymphoblastic leukemia: a Children's Oncology Group study.
9/2014Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
7/2014Loss of TBL1XR1 disrupts glucocorticoid receptor recruitment to chromatin and results in glucocorticoid resistance in a B-lymphoblastic leukemia model.
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William E Evans Research Topics

Disease

51Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
10/2015 - 01/2002
24Leukemia
06/2015 - 07/2002
13Neoplasms (Cancer)
07/2015 - 05/2003
6Residual Neoplasm
04/2015 - 01/2009
4Osteonecrosis (Kienbock's Disease)
10/2015 - 06/2009
4Hypersensitivity (Allergy)
07/2015 - 06/2009
2Infection
06/2009 - 05/2007
1Embolism and Thrombosis
10/2015
1Brain Ischemia (Cerebral Ischemia)
10/2015
1Neoplasm Metastasis (Metastasis)
03/2015
1Immediate Hypersensitivity
03/2015
1Peripheral Nervous System Diseases (PNS Diseases)
02/2015
1Philadelphia Chromosome
09/2014
1Lymphoma (Lymphomas)
08/2014
1Leukoencephalopathies
03/2014
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
04/2013
1Autoimmune Diseases (Autoimmune Disease)
01/2012
1Neutropenia
01/2010
1Thrombosis (Thrombus)
06/2009
1Renal Cell Carcinoma (Grawitz Tumor)
03/2008
1Bardet-Biedl Syndrome (Syndrome, Bardet-Biedl)
03/2008
1Weight Loss (Weight Reduction)
05/2007
1Hyperbilirubinemia
05/2007
1Brain Neoplasms (Brain Tumor)
02/2005
1Breast Neoplasms (Breast Cancer)
01/2005
1Cranial Nerve Diseases (Cranial Nerve Disorders)
11/2004
1Lymphoid Leukemia
05/2003

Drug/Important Bio-Agent (IBA)

18Methotrexate (Mexate)FDA LinkGeneric
03/2014 - 04/2002
126-Mercaptopurine (Mercaptopurine)FDA LinkGeneric
06/2015 - 01/2002
7Asparaginase (Elspar)FDA Link
07/2015 - 08/2004
6Thioguanine (Tioguanine)FDA Link
06/2015 - 06/2003
5Prednisolone (Predate)FDA LinkGeneric
06/2015 - 08/2004
5Dexamethasone (Maxidex)FDA LinkGeneric
03/2015 - 11/2004
4GlucocorticoidsIBA
10/2015 - 12/2008
3Phosphotransferases (Kinase)IBA
03/2015 - 08/2012
3AntibodiesIBA
03/2015 - 02/2012
3Messenger RNA (mRNA)IBA
11/2012 - 08/2006
3gamma-Glutamyl Hydrolase (Carboxypeptidase G2)IBA
08/2006 - 07/2002
3thiopurine methyltransferase (thiopurine S-methyltransferase)IBA
01/2006 - 02/2005
2RNA (Ribonucleic Acid)IBA
07/2015 - 03/2013
2Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
06/2015 - 07/2014
2Vincristine (Oncovin)FDA LinkGeneric
02/2015 - 08/2004
2DNA (Deoxyribonucleic Acid)IBA
02/2015 - 01/2003
2hydroquinone (Black and White)FDA Link
06/2012 - 10/2003
2purineIBA
05/2011 - 09/2004
2Folic Acid (Vitamin M)FDA LinkGeneric
01/2010 - 01/2005
2methotrexate polyglutamateIBA
05/2009 - 01/2005
2Reduced Folate Carrier ProteinIBA
08/2005 - 01/2005
2NucleotidesIBA
08/2005 - 06/2003
1Glutamate Receptors (Glutamate Receptor)IBA
10/2015
1Caspase 1 (ICE Protease)IBA
06/2015
1Triprolidine (Actidil)FDA Link
03/2015
1Cimetidine (Biomet)FDA LinkGeneric
03/2015
1Peptide Hydrolases (Proteases)IBA
03/2015
1Histamine (Histamine Dihydrochloride)FDA Link
03/2015
1CV 6209IBA
03/2015
1Immunoglobulin G (IgG)IBA
03/2015
1Platelet Activating FactorIBA
03/2015
1Transcription Factors (Transcription Factor)IBA
09/2014
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
09/2014
1EpitopesIBA
08/2014
1HLA DRB1 07 antigenIBA
08/2014
1HLA-DRB1 antigen (HLA DRB1)IBA
08/2014
1AntigensIBA
08/2014
1ChromatinIBA
07/2014
1voriconazole (Vfend)FDA LinkGeneric
06/2014
1Leucovorin (Folinic Acid)FDA Link
03/2014
1Azathioprine (Imuran)FDA LinkGeneric
04/2013
1Cytokine Receptors (Cytokine Receptor)IBA
08/2012
1EnzymesIBA
10/2011
1LipidsIBA
02/2011
1CholesterolIBA
02/2011
1Hydrocortisone (Cortisol)FDA LinkGeneric
02/2011
1InosineFDA Link
01/2010
1Inosine Triphosphate (ITP)IBA
01/2010
1TransferasesIBA
01/2010
1Small Interfering RNA (siRNA)IBA
12/2008
1Complementary DNA (cDNA)IBA
04/2008
1A 17 (A-17)IBA
03/2008
1human CYP3A5 proteinIBA
05/2007
1CytochromesIBA
05/2007
1Calcitriol Receptors (Calcitriol Receptor)IBA
05/2007
1Glucuronosyltransferase (UDP Glucuronosyltransferase)IBA
05/2007
1Aspartate-Ammonia Ligase (Asparagine Synthetase)IBA
06/2005
1Daunorubicin (Cerubidine)FDA LinkGeneric
08/2004
1Staphylococcal Protein A (A, Protein)IBA
08/2003
1Drug CombinationsIBA
05/2003
1High Mobility Group ProteinsIBA
01/2003
1DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
01/2003
1Nuclear Proteins (Protein, Nuclear)IBA
01/2003
1OxidoreductasesIBA
01/2003

Therapy/Procedure

12Drug Therapy (Chemotherapy)
04/2015 - 08/2004
7Remission Induction
04/2015 - 11/2004
3Combination Drug Therapy (Combination Chemotherapy)
01/2010 - 04/2005
2Cranial Irradiation
06/2009 - 11/2004
1Premedication
03/2015
1Ambulatory Care (Outpatient Care)
02/2015
1Heterologous Transplantation (Xenotransplantation)
01/2015
1Retreatment
03/2013
1Aftercare (After-Treatment)
03/2007