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Vikas Dudeja Selected Research

triptolide

6/2015Triptolide abrogates growth of colon cancer and induces cell cycle arrest by inhibiting transcriptional activation of E2F.
5/2015Primary and liver metastasis-derived cell lines from KrasG12D; Trp53R172H; Pdx-1 Cre animals undergo apoptosis in response to triptolide.
1/2015Minnelide effectively eliminates CD133(+) side population in pancreatic cancer.
6/2014Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the death receptor pathway.
6/2014Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells.
11/2013Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1.
4/2013Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor-kappa B activity.
1/2013miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death.
10/2012A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer.
9/2010Role of Hsp-70 in triptolide-mediated cell death of neuroblastoma.
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Vikas Dudeja Research Topics

Disease

17Neoplasms (Cancer)
06/2015 - 01/2007
16Pancreatic Neoplasms (Pancreatic Cancer)
06/2015 - 01/2007
7Pancreatitis
10/2014 - 01/2007
4Adenocarcinoma
02/2012 - 01/2007
3Neoplasm Metastasis (Metastasis)
06/2015 - 10/2007
3Neuroblastoma
04/2013 - 08/2009
3Stomach Neoplasms (Stomach Cancer)
02/2012 - 01/2011
3Necrosis
12/2011 - 01/2007
1Colorectal Neoplasms (Colorectal Cancer)
06/2015
1Colonic Neoplasms (Colon Cancer)
06/2015
1Tics (Tic)
05/2014
1Chronic Pancreatitis
05/2013
1Shock
04/2013
1Inflammation
12/2011
1Cholangiocarcinoma
06/2011
1Residual Neoplasm
09/2010
1Sarcoma (Soft Tissue Sarcoma)
07/2010
1Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
03/2010
1Pancreatic Diseases (Pancreatic Disease)
03/2008
1Carcinoma (Carcinomatosis)
01/2007
1Hyperamylasemia
01/2007
1Edema
01/2007

Drug/Important Bio-Agent (IBA)

16triptolideIBA
06/2015 - 10/2007
5Caerulein (Ceruletide)IBA
10/2014 - 04/2007
4Small Interfering RNA (siRNA)IBA
01/2012 - 01/2007
3TrypsinogenIBA
10/2014 - 12/2011
3Messenger RNA (mRNA)IBA
04/2013 - 01/2007
3HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA
05/2009 - 01/2007
2Transcription Factors (Transcription Factor)IBA
05/2015 - 12/2011
2Caspase 3 (Caspase-3)IBA
05/2015 - 02/2010
2Annexin A5IBA
05/2015 - 01/2007
2Proteins (Proteins, Gene)IBA
05/2015 - 05/2014
2DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
05/2015 - 09/2010
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2014 - 02/2010
2Heat-Shock Proteins (Heat-Shock Protein)IBA
08/2009 - 03/2008
2QuercetinIBA
05/2009 - 01/2007
2Cholecystokinin (Pancreozymin)IBA
04/2007 - 01/2007
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
06/2015
1Inositol (Myoinositol)IBA
06/2014
1Peptide Initiation Factors (Initiation Factor)IBA
06/2014
1Phosphotransferases (Kinase)IBA
06/2014
1Sp1 Transcription FactorIBA
11/2013
1NF-kappa B (NF-kB)IBA
04/2013
1Apoptosis Regulatory ProteinsIBA
01/2013
1Cathepsin BIBA
01/2012
1GO 201IBA
01/2012
1RNA (Ribonucleic Acid)IBA
01/2012
1Glycoproteins (Glycoprotein)IBA
01/2012
1imatinib (Gleevec)FDA Link
03/2010
1Caspase 9IBA
02/2010
1CalciumIBA
05/2009
1Peroxidase (Myeloperoxidase)IBA
07/2008
1arseniteIBA
03/2008
1AmylasesFDA Link
03/2008
1Arginine (L-Arginine)FDA Link
04/2007
1CytokinesIBA
01/2007
1HydrolasesIBA
01/2007
1ChemokinesIBA
01/2007
1Enzyme Precursors (Zymogens)IBA
01/2007
1tebufenozide (Mimic)IBA
01/2007

Therapy/Procedure

3Heterologous Transplantation (Xenotransplantation)
06/2015 - 10/2012
3Lymph Node Excision (Lymph Node Dissection)
02/2012 - 01/2011
3Drug Therapy (Chemotherapy)
08/2010 - 01/2007
2Radiotherapy
09/2013 - 07/2010
2Gastrectomy
02/2012 - 01/2011
2Injections
09/2010 - 08/2009
1Therapeutics
06/2015
1Intraperitoneal Injections
05/2013