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C A Dinarello Selected Research

Interleukin-18 (Interleukin 18)

1/2009Interleukin-18 binding protein in the sera of patients with Wegener's granulomatosis.
11/2006IL-32, a novel cytokine with a possible role in disease.
11/2003Interleukin-18, interleukin-18 binding protein and impaired production of interferon-gamma in chronic renal failure.
9/2002The IL-1 family and inflammatory diseases.
8/2002Interferon-alpha induces interleukin-18 binding protein in chronic hepatitis C patients.
12/2001Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis.
11/2001Novel targets for interleukin 18 binding protein.
10/2001Acute toxoplasmosis leads to lethal overproduction of Th1 cytokines.
10/2001Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production.
9/2001Interleukin-18 inhibits human immunodeficiency virus type 1 production in peripheral blood mononuclear cells.
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C A Dinarello Research Topics

Disease

14Inflammation
05/2008 - 02/2000
7Neoplasms (Cancer)
09/2012 - 01/2000
5Necrosis
01/2011 - 05/2001
5Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
05/2008 - 08/2000
5Infection
08/2002 - 08/2000
5Sepsis (Septicemia)
06/2001 - 08/2000
4Rheumatoid Arthritis
09/2002 - 08/2000
3Autoimmune Diseases (Autoimmune Disease)
09/2012 - 09/2002
3Colitis
05/2008 - 10/2001
3Arthritis (Polyarthritis)
12/2001 - 09/2000
2Chronic Kidney Failure (Chronic Renal Failure)
09/2009 - 11/2003
2Colonic Neoplasms (Colon Cancer)
05/2008 - 09/2000
2Ureteral Obstruction
04/2007 - 02/2005
2Ischemia
02/2005 - 02/2001
2Crohn Disease (Crohn's Disease)
11/2004 - 10/2001
2Endotoxemia
06/2001 - 03/2000
2Acute Kidney Injury (Acute Renal Failure)
06/2001 - 05/2001
1Nasal Polyps (Nasal Polyp)
01/2012
1Chronic Granulomatous Disease
02/2011
1Vasculitis (Vasculitides)
01/2009
1Wegener Granulomatosis (Wegener's Granulomatosis)
01/2009
1Alzheimer Disease (Alzheimer's Disease)
05/2007
1Fibrosis (Cirrhosis)
04/2007
1Chronic Renal Insufficiency
11/2003
1Uremia
11/2003
1Liver Failure
08/2002
1Chronic Hepatitis C
08/2002
1Disease Progression
12/2001
1Experimental Arthritis
12/2001
1Synovitis
12/2001
1Hemorrhage
11/2001
1Diarrhea
11/2001
1Weight Loss (Weight Reduction)
11/2001
1Toxoplasmosis
10/2001
1Vascular Diseases (Vascular Disease)
08/2001
1Thrombosis (Thrombus)
08/2001
1Renal Insufficiency (Renal Failure)
06/2001
1Hypotension (Low Blood Pressure)
06/2001
1Salmonella Infections (Salmonellosis)
02/2001
1Cardiomyopathies (Cardiomyopathy)
01/2001
1Septic Shock (Toxic Shock Syndrome)
01/2001
1Heart Diseases (Heart Disease)
01/2001
1Heart Failure
01/2001
1Myocardial Infarction
01/2001

Drug/Important Bio-Agent (IBA)

19Interleukin-18 (Interleukin 18)IBA
01/2009 - 01/2000
12Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
05/2007 - 01/2000
12Interleukin-1 (Interleukin 1)IBA
05/2007 - 01/2000
7CytokinesIBA
05/2007 - 01/2000
4Interleukin-12 (IL 12)IBA
01/2011 - 06/2000
3Histone Deacetylases (Histone Deacetylase)IBA
09/2012 - 01/2006
3Interferon-gamma (Interferon, gamma)IBA
09/2009 - 11/2003
3interleukin-18 binding proteinIBA
01/2009 - 08/2002
3InterleukinsIBA
11/2004 - 08/2000
2Messenger RNA (mRNA)IBA
01/2012 - 06/2000
2Interleukin-1beta (Interleukin 1 beta)IBA
06/2009 - 05/2001
2NF-kappa B (NF-kB)IBA
05/2008 - 04/2007
2Histone Deacetylase InhibitorsIBA
05/2008 - 01/2006
2salicylhydroxamic acid (SHAM)IBA
04/2007 - 02/2005
2Nitric Oxide Synthase (NO Synthase)IBA
04/2007 - 06/2001
2CollagenIBA
04/2007 - 12/2001
2IceIBA
11/2001 - 03/2000
2Dextran SulfateIBA
11/2001 - 10/2001
2Caspase 1 (ICE Protease)IBA
11/2001 - 02/2001
1Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
02/2011
1Interleukin-6 (Interleukin 6)IBA
06/2009
1Carrier Proteins (Binding Protein)IBA
01/2009
1Dextrans (Dextran)FDA Link
05/2008
1ITF 2357IBA
05/2008
1vorinostat (suberoylanilide hydroxamic acid)FDA Link
05/2008
1Interleukin-10 (Interleukin 10)IBA
05/2008
1SodiumIBA
05/2008
1Histones (Histone)IBA
05/2008
1AngiotensinogenIBA
04/2007
1InulinFDA Link
04/2007
1C-Reactive ProteinIBA
11/2004
1Glycoproteins (Glycoprotein)IBA
11/2004
1Interleukin-15 (Interleukin 15)IBA
09/2002
1Interferon-alpha (Interferon Alfa)FDA Link
08/2002
1Neutralizing AntibodiesIBA
12/2001
1Antirheumatic Agents (DMARD)IBA
12/2001
1Immunoglobulin G (IgG)IBA
12/2001
1Fas Ligand Protein (Fas Ligand)IBA
11/2001
1ChemokinesIBA
11/2001
1InterferonsIBA
10/2001
1AntigensIBA
09/2001
1p38 Mitogen-Activated Protein KinasesIBA
08/2001
1ThrombinFDA Link
08/2001
1Oncogene Proteins (Oncogene Protein)IBA
07/2001
1Nitric Oxide (Nitrogen Monoxide)FDA Link
06/2001
1Vasoconstrictor AgentsIBA
06/2001
1Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
06/2001
1A-factor (Streptomyces)IBA
06/2001
1Vasodilator Agents (Vasodilators)IBA
06/2001
1Urea (Carbamide)FDA LinkGeneric
05/2001
1NitrogenIBA
05/2001
1CreatinineIBA
05/2001
1Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA
02/2001

Therapy/Procedure

2Renal Dialysis (Hemodialysis)
09/2009 - 11/2003
1Renal Replacement Therapy (Therapies, Renal Replacement)
05/2004
1Aftercare (After-Treatment)
12/2001