Cytochrome P-450 Enzyme System

A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.

Also Known As:

Cytochrome P450; Cytochrome P 450; Cytochrome P-450; Cytochrome P-450 Monooxygenase; Cytochrome P-450 Oxygenase; Cytochrome P 450 Dependent Monooxygenase; Cytochrome P 450 Enzyme System; Cytochrome P 450 Monooxygenase; Cytochrome P 450 Oxygenase; Monooxygenase, Cytochrome P-450; Monooxygenase, Cytochrome P-450-Dependent; Cytochrome P-450-Dependent Monooxygenase

Enzymes and Coenzymes
- Enzymes: 34502
  - Oxidoreductases: 9264
    - Oxygenases: 89
      - Mixed Function Oxygenases: 449
        Cytochrome P-450 Enzyme System: 3623
- Cytochromes: 1553
  - Cytochrome P-450 Enzyme System: 3623
Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Hemeproteins: 140
    - Cytochromes: 1553
      - Cytochrome P-450 Enzyme System: 3623

Kelsey Dillehay Selected Research

Kelsey Dillehay Research Topics

Disease

Drug/Important Bio-Agent (IBA)