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Lawrence N Diebel Selected Research

Secretory Immunoglobulin A (SIgA)

9/2014Reinforcement of the intestinal mucus layer protects against Clostridium difficile intestinal injury in vitro.
4/2010Sequence of immunoglobulin isotype exposure modulates inflammatory response to bacteria and lipopolysaccharide in vitro.
4/2010Secretory immunoglobulin A abrogates inflammatory responses and improves mortality after pseudomonas pneumonia.
6/2008Secretory immunoglobulin a blunts gut-mediated priming of neutrophils in vitro.
3/2006A comparative study of secretory immunoglobulin A and immunoglobulin G in host defense in an in vitro pneumonia model.
11/2005Immunoglobulin a modulates inflammatory responses in an in vitro model of pneumonia.
10/2004Immunoglobulin A protease is a virulence factor for gram-negative pneumonia.
10/2003Enterocyte apoptosis and barrier function are modulated by SIgA after exposure to bacteria and hypoxia/reoxygenation.

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Lawrence N Diebel Research Topics

Disease

9Pneumonia (Pneumonitis)
04/2012 - 10/2004
8Shock
07/2012 - 05/2005
6Wounds and Injuries (Trauma)
12/2015 - 04/2003
6Infection
09/2014 - 10/2004
4Hemorrhagic Shock
12/2015 - 10/2008
4Anoxia (Hypoxia)
12/2015 - 08/2003
3Necrosis
09/2014 - 08/2009
2Ulcerative Colitis
10/2014 - 09/2014
2Ischemia
10/2013 - 10/2003
2Lung Injury
10/2013 - 08/2009
2Critical Illness (Critically Ill)
10/2011 - 03/2003
1Reperfusion Injury
12/2015
1Multiple Organ Failure (MODS)
02/2011
1Renal Insufficiency (Renal Failure)
02/2011
1Bacterial Pneumonia
04/2010
1Inflammation
06/2009
1Hypersensitivity (Allergy)
06/2008
1Sepsis (Septicemia)
06/2008

Drug/Important Bio-Agent (IBA)

8Secretory Immunoglobulin A (SIgA)IBA
09/2014 - 10/2003
7Immunoglobulin A (IgA)IBA
09/2014 - 03/2003
4Ethanol (Ethyl Alcohol)IBA
12/2009 - 10/2007
2Phosphatidylcholines (Phosphatidylcholine)IBA
10/2014 - 09/2014
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2014 - 05/2005
2Propidium (Propidium Iodide)IBA
04/2013 - 08/2009
2Estrogens (Estrogen)FDA Link
04/2012 - 09/2011
2salicylhydroxamic acid (SHAM)IBA
06/2009 - 10/2008
2IgA-specific serine endopeptidaseIBA
05/2009 - 10/2004
2Immunoglobulin G (IgG)IBA
03/2006 - 11/2005
1Phenobarbital (Luminal)FDA Link
12/2015
1EnzymesIBA
12/2015
1Tranexamic Acid (AMCA)FDA Link
12/2015
1TrypsinIBA
12/2015
1Interleukin-6 (Interleukin 6)IBA
09/2014
1Verapamil (Calan)FDA LinkGeneric
07/2014
1NicotineFDA Link
10/2013
1fluorescein isothiocyanate dextranIBA
04/2013
1Virulence Factors (Pathogenicity Factors)IBA
04/2013
1ProteomeIBA
07/2012
1Estradiol (Estrace)FDA LinkGeneric
04/2012
1Dihydrotestosterone (Androstanolone)IBA
04/2012
1Cimetidine (Biomet)FDA LinkGeneric
10/2011
1Histamine (Histamine Dihydrochloride)FDA Link
10/2011
1crystalloid solutionsIBA
02/2011
1CreatinineIBA
02/2011
1Peroxidase (Myeloperoxidase)IBA
04/2010
1Polymeric Immunoglobulin Receptors (Polymeric Immunoglobulin Receptor)IBA
04/2010
1Bisbenzimidazole (Hoechst 33258)IBA
08/2009
1Superoxides (Superoxide)IBA
06/2009
1Pancreatic Elastase (Elastase)IBA
06/2009
1CytokinesIBA
07/2007
1Peptide Hydrolases (Proteases)IBA
10/2004
1OxygenIBA
08/2003
1NitrogenIBA
08/2003
1Hydrochloric Acid (Hydrogen Chloride)FDA Link
08/2003
1Carbon DioxideIBA
08/2003

Therapy/Procedure

4Resuscitation
07/2012 - 04/2003
1Vagus Nerve Stimulation
10/2013
1Intensive Care (Surgical Intensive Care)
10/2004