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Christopher P Denton Selected Research

Diffuse systemic sclerosis

6/2015Prediction of worsening of skin fibrosis in patients with diffuse cutaneous systemic sclerosis using the EUSTAR database.
12/2012Sustained improvement of diffuse systemic sclerosis following human cytomegalovirus infection offers insight into pathogenesis and therapy.
10/2011Loss of PTEN expression by dermal fibroblasts causes skin fibrosis.
9/2007Treatment of autoimmune disease with rabbit anti-T lymphocyte globulin: clinical efficacy and potential mechanisms of action.
7/2007Relationship between change in skin score and disease outcome in diffuse cutaneous systemic sclerosis: application of a latent linear trajectory model.
1/2005Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis.

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Christopher P Denton Research Topics

Disease

50Systemic Scleroderma (Systemic Sclerosis)
07/2015 - 05/2003
29Fibrosis (Cirrhosis)
06/2015 - 07/2003
12Pulmonary Fibrosis (Hamman Rich Syndrome)
06/2014 - 07/2003
6Inflammation
11/2014 - 09/2007
5Autoimmune Diseases (Autoimmune Disease)
01/2016 - 09/2007
5Pulmonary Hypertension (Ayerza Syndrome)
03/2015 - 05/2003
5Connective Tissue Diseases (Connective Tissue Disease)
01/2015 - 05/2010
5Interstitial Lung Diseases (Interstitial Lung Disease)
11/2013 - 09/2012
5Sclerosis
01/2011 - 12/2007
4Cicatrix (Scar)
07/2014 - 06/2004
4Skin Diseases
11/2009 - 07/2007
3Vasculitis (Vasculitides)
01/2016 - 09/2007
3Telangiectasis (Telangiectasia)
06/2014 - 11/2013
3Disease Progression
05/2013 - 02/2006
3Ulcer
05/2012 - 01/2011
3Wounds and Injuries (Trauma)
09/2010 - 12/2006
2Myositis (Idiopathic Inflammatory Myopathies)
01/2016 - 07/2015
2Blister (Bulla)
01/2015 - 01/2015
2Sarcoidosis (Schaumann Disease)
05/2013 - 01/2013
2Idiopathic Pulmonary Fibrosis
05/2013 - 04/2013
2Pain (Aches)
01/2012 - 01/2011
2Chronic Disease (Chronic Diseases)
12/2007 - 10/2007
1Polymyositis
01/2016
1Infection
01/2016
1Anoxia (Hypoxia)
07/2015
1Synovitis
06/2015
1Communicable Diseases (Infectious Diseases)
04/2015
1Raynaud Disease (Raynaud's Disease)
06/2014
1Contracture
06/2014
1Calcinosis
06/2014
1Neoplasms (Cancer)
01/2014
1Right Ventricular Dysfunction
01/2013

Drug/Important Bio-Agent (IBA)

20Idiopathic pulmonary hypertensionIBA
03/2015 - 05/2003
10Transforming Growth Factor beta (TGF-beta)IBA
01/2010 - 07/2003
8Bleomycin (Blenoxane)FDA LinkGeneric
08/2013 - 04/2008
8CollagenIBA
01/2011 - 07/2003
6Diffuse systemic sclerosisIBA
06/2015 - 01/2005
6AutoantibodiesIBA
01/2014 - 09/2007
5Phosphotransferases (Kinase)IBA
01/2015 - 07/2003
5AntibodiesIBA
06/2014 - 09/2007
4Transforming Growth Factors (Transforming Growth Factor)IBA
03/2015 - 01/2011
4Collagen Type I (Type I Collagen)IBA
01/2015 - 12/2006
4CytokinesIBA
01/2015 - 04/2013
4Endothelin-1 (Endothelin 1)IBA
01/2011 - 05/2004
4Connective Tissue Growth FactorIBA
01/2011 - 01/2004
3Protein Kinases (Protein Kinase)IBA
01/2015 - 10/2008
3Carbon MonoxideIBA
01/2014 - 06/2007
3Extracellular Matrix ProteinsIBA
01/2013 - 10/2007
3bosentan (Tracleer)FDA Link
01/2011 - 05/2003
3indium-bleomycinIBA
01/2011 - 04/2008
3Endothelin Receptors (Endothelin Receptor)IBA
05/2010 - 05/2003
2Intravenous Immunoglobulins (IVIG)FDA Link
01/2016 - 07/2015
2SU 5416 (SU5416)IBA
07/2015 - 03/2015
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2015 - 11/2014
2Thrombospondin 1IBA
01/2015 - 01/2011
2RNA Polymerase IIIIBA
01/2014 - 10/2009
2Interleukin-6 (Interleukin 6)IBA
04/2013 - 07/2012
2Brain Natriuretic Peptide (Natrecor)FDA Link
03/2012 - 06/2006
2ametantrone (HAQ)IBA
11/2011 - 05/2008
2Fibronectins (Fibronectin)IBA
11/2010 - 12/2006
2Cyclophosphamide (Cytoxan)FDA LinkGeneric
11/2009 - 12/2006
2Azathioprine (Imuran)FDA LinkGeneric
11/2009 - 12/2006
2Chemokine CCL7IBA
01/2009 - 07/2003
2Proteins (Proteins, Gene)IBA
02/2008 - 06/2004
1Immunoglobulins (Immunoglobulin)IBA
07/2015
1von Willebrand FactorIBA
07/2015
1Creatine Kinase (Creatine Phosphokinase)IBA
06/2015
1Membrane Proteins (Integral Membrane Proteins)IBA
04/2015
1Fibrinogen (Factor I)FDA Link
04/2015
1Type II Bone Morphogenetic Protein Receptors (Bone Morphogenetic Protein Receptor Type II)IBA
03/2015
1InterleukinsIBA
01/2015
1ChemokinesIBA
01/2015
1platelet-derived growth factor AIBA
01/2015
1Platelet-Derived Growth FactorIBA
01/2015
1Transcription Factors (Transcription Factor)IBA
01/2015
1Messenger RNA (mRNA)IBA
01/2015
1S-NitrosothiolsIBA
12/2014
1Toll-Like Receptor 4IBA
11/2014
1beta-cyclodextrin tetradecasulfate (CTDS)IBA
05/2014
14- methyl- N- (3- (4- methylimidazol- 1- yl)- 5- (trifluoromethyl)phenyl)- 3- ((4- pyridin- 3- ylpyrimidin- 2- yl)amino)benzamide (nilotinib)FDA Link
12/2013
1Methyl-CpG-Binding Protein 2IBA
12/2013
1Antineutrophil Cytoplasmic Antibodies (ANCA)IBA
10/2013
1Protein Isoforms (Isoforms)IBA
08/2013
1Interleukin-2 (IL2)IBA
07/2013
1interleukin-21 (interleukin 21)IBA
07/2013
1Mucin-5BIBA
05/2013
1MucinsIBA
05/2013
1Transfer Factor (Factor, Transfer)IBA
05/2013
1Interleukin-8 (Interleukin 8)IBA
04/2013
1Biological Markers (Surrogate Marker)IBA
04/2013
1Interleukin-10 (Interleukin 10)IBA
04/2013
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
04/2013
1Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
04/2013
1Vasodilator Agents (Vasodilators)IBA
01/2013
1InterferonsIBA
01/2013
1Antinuclear AntibodiesIBA
12/2012

Therapy/Procedure

3Subcutaneous Injections
09/2009 - 07/2008
1Immunotherapy
01/2016
1Oral Administration
08/2013
1Transplantation (Transplant Recipients)
01/2013