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Devorah Crown Selected Research

anthrax toxin (anthrax lethal factor)

3/2015A heterodimer of a VHH (variable domains of camelid heavy chain-only) antibody that inhibits anthrax toxin cell binding linked to a VHH antibody that blocks oligomer formation is highly protective in an anthrax spore challenge model.
3/2013Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumors.
1/2013Anthrax edema factor toxicity is strongly mediated by the N-end rule.
11/2011Mouse monoclonal antibodies to anthrax edema factor protect against infection.
11/2010Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice.
7/2009Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo.
1/2008Role of N-terminal amino acids in the potency of anthrax lethal factor.

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Devorah Crown Research Topics

Disease

12Anthrax
03/2015 - 01/2008
8Infection
01/2014 - 07/2009
5Edema
09/2013 - 08/2009
2Neoplasms (Cancer)
03/2013 - 07/2009
1Peritonitis
01/2014
1Toxoplasmosis
01/2014
1Shock
08/2010

Drug/Important Bio-Agent (IBA)

7anthrax toxin (anthrax lethal factor)IBA
03/2015 - 01/2008
4AntigensIBA
03/2015 - 11/2011
4edema factorIBA
03/2015 - 08/2009
2InflammasomesIBA
01/2014 - 01/2014
2Caspase 1 (ICE Protease)IBA
01/2014 - 01/2010
2Virulence Factors (Pathogenicity Factors)IBA
09/2013 - 02/2012
2Monoclonal AntibodiesIBA
09/2013 - 11/2011
2Proteins (Proteins, Gene)IBA
09/2013 - 07/2009
2Adenylate Cyclase (Adenylyl Cyclase)IBA
01/2013 - 02/2012
2Calmodulin (Calcium-Dependent Activator Protein)IBA
01/2013 - 08/2009
1AntibodiesIBA
03/2015
1arsenic trioxide (Trisenox)FDA Link
01/2014
1Uric Acid (Urate)IBA
01/2014
1sodium arseniteIBA
01/2014
1FlagellinIBA
01/2014
1Arsenicals (Arsenic Compounds)IBA
01/2014
1NigericinIBA
01/2014
1Leucine (L-Leucine)FDA Link
01/2014
1Interleukin-18 (Interleukin 18)IBA
01/2014
1marenostrin (pyrin)IBA
01/2014
1ExotoxinsIBA
09/2013
1Anti-Bacterial Agents (Antibiotics)IBA
09/2013
1Peptide Hydrolases (Proteases)IBA
03/2013
1Adenosine Monophosphate (AMP)IBA
01/2013
1Adenosine Triphosphate (ATP)IBA
01/2013
1Quinidine (Chinidin)FDA LinkGeneric
08/2010
1Cathepsin BIBA
08/2010
1CA 074 methyl esterIBA
08/2010
1Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
01/2010
1Interleukin-1 (Interleukin 1)IBA
01/2010
1Cyclic AMP (AMP, Cyclic)IBA
08/2009
1von Willebrand FactorIBA
07/2009
1Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA
05/2009
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2008

Therapy/Procedure

2Therapeutics
03/2015 - 09/2013