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Timothy M Cox Selected Research

imiglucerase (Cerezyme)

6/2015Eliglustat compared with imiglucerase in patients with Gaucher's disease type 1 stabilised on enzyme replacement therapy: a phase 3, randomised, open-label, non-inferiority trial.
1/2015Enzyme replacement and substrate reduction therapy for Gaucher disease.
12/2012Effects of switching from a reduced dose imiglucerase to velaglucerase in type 1 Gaucher disease: clinical and biochemical outcomes.
1/2012Imiglucerase in the treatment of Gaucher disease: a history and perspective.
3/2010Guidelines for the restart of imiglucerase in patients with Gaucher disease: recommendations from the European Working Group on Gaucher disease.
1/2010Force majeure: therapeutic measures in response to restricted supply of imiglucerase (Cerezyme) for patients with Gaucher disease.

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Timothy M Cox Research Topics

Disease

21Gaucher Disease (Gaucher's Disease)
07/2015 - 05/2003
9Iron Overload
01/2015 - 11/2002
5Sandhoff Disease (Sandhoff's Disease)
02/2012 - 07/2006
4GM2 Gangliosidoses (GM2 Gangliosidosis)
09/2012 - 06/2009
3Osteonecrosis (Kienbock's Disease)
01/2012 - 01/2011
3Hemochromatosis (Bronze Diabetes)
03/2010 - 05/2003
2Lysosomal Storage Diseases (Lysosomal Storage Disease)
02/2014 - 10/2010
2Tay-Sachs Disease
02/2012 - 07/2006
1Myocardial Infarction
06/2015
1Psychotic Disorders (Schizoaffective Disorder)
06/2015
1Pain (Aches)
01/2015
1Plasmacytoma
01/2015
1Body Weight (Weight, Body)
01/2015
1Lymphoma (Lymphomas)
01/2015
1Acute Intermittent Porphyria (Porphyria, Acute)
01/2015
1Neurologic Manifestations (Neurological Manifestations)
02/2014
1Parkinson Disease (Parkinson's Disease)
02/2013
1Fabry Disease (Fabry's Disease)
01/2013
1Gliosis
09/2012
1Rare Diseases (Rare Disease)
01/2012
1Tyrosinemias (Tyrosinemia)
01/2012
1Alkaptonuria
01/2012
1Neurodegenerative Diseases (Neurodegenerative Disease)
09/2011
1Demyelinating Diseases (Demyelinating Disease)
09/2011
1Globoid Cell Leukodystrophy (Krabbe Disease)
09/2011
1Metachromatic Leukodystrophy (Sulfatide Lipidosis)
12/2010
1Disease Progression
12/2010
1Acute Erythroblastic Leukemia (Erythroleukemia)
10/2010
1Melanoma (Melanoma, Malignant)
10/2010
1Nervous System Diseases (Neurological Disorders)
06/2009
1Gangliosidoses (Gangliosidosis)
06/2009
1Erythropoietic Protoporphyria
02/2008
1Delayed Hypersensitivity (Hypersensitivity, Type IV)
09/2006
1Hypersensitivity (Allergy)
09/2006
1Inflammation
07/2006
1Liver Diseases (Liver Disease)
08/2005
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
08/2005
1Porphyrias
07/2005
1Variegate Porphyria (Protoporphyrinogen Oxidase Deficiency)
07/2005

Drug/Important Bio-Agent (IBA)

9Glucosylceramidase (Glucocerebrosidase)IBA
03/2015 - 05/2003
9IronIBA
01/2015 - 11/2002
6imiglucerase (Cerezyme)FDA Link
06/2015 - 01/2010
5Biological Markers (Surrogate Marker)IBA
01/2012 - 01/2004
5hepcidinIBA
06/2011 - 03/2004
4miglustat (Zavesca)FDA Link
01/2015 - 05/2003
4metal transporting protein 1 (ferroportin)IBA
09/2014 - 08/2005
4type 2 HemochromatosisIBA
10/2005 - 11/2002
3Hexosaminidases (Hexosaminidase)IBA
09/2012 - 07/2006
2CytokinesIBA
07/2015 - 01/2011
2ChemokinesIBA
07/2015 - 01/2011
2ceramide glucosyltransferaseIBA
01/2015 - 10/2010
2Chemokine CCL5IBA
01/2012 - 01/2011
2chitotriosidaseIBA
01/2011 - 01/2004
2Mannose (D-Mannose)IBA
01/2011 - 10/2004
2LipidsIBA
01/2010 - 04/2008
2G(M2) Ganglioside (Ganglioside GM2)IBA
04/2008 - 07/2006
2tartrate-resistant acid phosphatase (TSAP)IBA
09/2006 - 10/2003
2Transferrin Receptors (Transferrin Receptor)IBA
10/2005 - 05/2003
1HydrolasesIBA
07/2015
1SphingosineIBA
07/2015
1sphingosyl beta-glucosideIBA
01/2015
1N-(4-aminophenethyl)spiroperidol (NAPS)IBA
01/2015
1Uridine Diphosphate (UDP)IBA
01/2015
1heme arginateIBA
01/2015
1GlucosidasesIBA
01/2015
1ParaproteinsIBA
01/2015
1Lysergic Acid Diethylamide (LSD)IBA
02/2014
1agalsidase betaFDA Link
01/2013
1Tetracycline (Achromycin)FDA LinkGeneric
09/2012
1GlycoconjugatesIBA
09/2012
1G(M2) Activator ProteinIBA
02/2012
1Tyrosine (L-Tyrosine)FDA Link
01/2012
1nitisinone (Orfadin)FDA Link
01/2012
1Homogentisic AcidIBA
01/2012
1GalactosylceramidaseIBA
09/2011
1Transferrin (beta 2 Transferrin)IBA
06/2011
1tartaric acid (tartrate)FDA Link
10/2010
1GangliosidesIBA
10/2010
1Tissue ExtractsIBA
01/2010
1SphingolipidsIBA
01/2010
1Uridine Diphosphate Glucose (UDP Glucose)IBA
01/2010
1First StepIBA
01/2010
1Interleukin-6 (Interleukin 6)IBA
06/2009
1Sulfoglycosphingolipids (Sulfatides)IBA
04/2008
1Cyclosporine (Ciclosporin)FDA LinkGeneric
02/2008
1AntigensIBA
09/2006
1Picryl Chloride (Trinitrochlorobenzene)IBA
09/2006
1OvalbuminIBA
09/2006
1beta-N-AcetylhexosaminidasesIBA
07/2006
1HemosiderinIBA
08/2005
1Protoporphyrinogen Oxidase (Protox)IBA
07/2005
1Gold CompoundsIBA
09/2004

Therapy/Procedure

7Enzyme Replacement Therapy
06/2015 - 10/2004
5Enzyme Therapy
02/2014 - 05/2003
2Splenectomy
07/2015 - 01/2011
1Analgesia
01/2015
1Complementary Therapies (Alternative Medicine)
02/2014
1Stem Cell Transplantation
12/2010
1Nebulizers and Vaporizers (Inhaler)
04/2008
1Liver Transplantation
02/2008