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Jianzhong Chen Selected Research

ursolic acid

4/2015A pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis.
4/2015Dendrimeric anticancer prodrugs for targeted delivery of ursolic acid to folate receptor-expressing cancer cells: synthesis and biological evaluation.
1/2015UP12, a novel ursolic acid derivative with potential for targeting multiple signaling pathways in hepatocellular carcinoma.
1/2014Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis.

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Jianzhong Chen Research Topics

Disease

8Neoplasms (Cancer)
04/2015 - 01/2012
2Carcinoma (Carcinomatosis)
05/2015 - 05/2014
2Neoplasm Metastasis (Metastasis)
04/2015 - 09/2014
2Prostatic Neoplasms (Prostate Cancer)
09/2014 - 05/2014
1Hemorrhage
05/2015
1Melanoma (Melanoma, Malignant)
04/2015
1Hepatocellular Carcinoma (Hepatoma)
01/2015
1Endometrial Neoplasms (Endometrial Cancer)
09/2014
1Adenocarcinoma
09/2014
1Glioma (Gliomas)
09/2014
1Meningioma (Meningiomas)
09/2014
1Alzheimer Disease (Alzheimer's Disease)
10/2013
1Chronic Pancreatitis
08/2007
1Pancreatic Neoplasms (Pancreatic Cancer)
08/2007

Drug/Important Bio-Agent (IBA)

4ursolic acidIBA
04/2015 - 01/2014
2Proteins (Proteins, Gene)IBA
02/2015 - 08/2007
2Adenosine Triphosphate (ATP)IBA
01/2015 - 01/2014
2Deoxyglucose (2 Deoxy D glucose)IBA
01/2015 - 01/2014
2Glucose (Dextrose)FDA LinkGeneric
01/2015 - 01/2014
2Lactic AcidFDA LinkGeneric
01/2015 - 01/2014
2GlucokinaseIBA
01/2015 - 01/2014
2Mifepristone (RU 486)FDA Link
09/2014 - 03/2014
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
04/2015
1Cell Adhesion MoleculesIBA
04/2015
1ProdrugsIBA
04/2015
1Folic Acid (Vitamin M)FDA LinkGeneric
04/2015
1Adenosine Triphosphatases (ATPase)IBA
01/2015
1EnzymesIBA
01/2015
1Facilitative Glucose Transport Proteins (Glucose Transporter)IBA
01/2015
1NF-kappa B (NF-kB)IBA
09/2014
1PalladiumIBA
05/2014
1tebufenozide (Mimic)IBA
05/2014
1Sarcosine (Methylglycine)IBA
05/2014
1CarbonIBA
01/2014
1HexokinaseIBA
01/2014
1Free Radical ScavengersIBA
10/2013
1Tumor Suppressor Protein p53IBA
01/2012
1acetonitrileIBA
08/2007
1ApolipoproteinsIBA
08/2007

Therapy/Procedure

1Esophagectomy
05/2015
1Oral Administration
04/2015
1Chemoprevention
09/2014