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Byron Caughey Selected Research

PrPSc Proteins

1/2017Novel strain properties distinguishing sporadic prion diseases sharing prion protein genotype and prion type.
1/2016Advanced tests for early and accurate diagnosis of Creutzfeldt-Jakob disease.
1/2016PrPSc-Specific Antibody Reveals C-Terminal Conformational Differences between Prion Strains.
8/2014A test for Creutzfeldt-Jakob disease using nasal brushings.
6/2014Heparin binding confers prion stability and impairs its aggregation.
1/2014Anti-prion activity of a panel of aromatic chemical compounds: in vitro and in silico approaches.
1/2012Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC.
5/2011Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra.
8/2009Human variant Creutzfeldt-Jakob disease and sheep scrapie PrP(res) detection using seeded conversion of recombinant prion protein.
3/2006Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res.
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Byron Caughey Research Topics

Disease

62Prion Diseases (Transmissible Spongiform Encephalopathies)
01/2022 - 03/2002
35Scrapie
01/2022 - 03/2002
19Infections
01/2021 - 03/2002
15Neurodegenerative Diseases (Neurodegenerative Disease)
01/2022 - 01/2003
11Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease)
11/2020 - 02/2009
10Parkinson Disease (Parkinson's Disease)
01/2022 - 09/2015
10Sporadic Creutzfeldt-Jakob Disease
01/2021 - 02/2012
9Chronic Wasting Disease
11/2019 - 01/2006
7Synucleinopathies
01/2022 - 01/2018
5Proteostasis Deficiencies
11/2019 - 10/2006
5Bovine Spongiform Encephalopathy (Mad Cow Disease)
09/2016 - 02/2009
4Tauopathies
01/2022 - 01/2015
4Alzheimer Disease (Alzheimer's Disease)
01/2020 - 06/2005
3Dementia (Dementias)
01/2021 - 01/2018
3Acquired CJD
01/2020 - 01/2016
3Amyloid Plaque
10/2015 - 06/2005
3Brain Diseases (Brain Disorder)
10/2015 - 04/2010
3Neuroblastoma
01/2014 - 05/2003
2Multiple System Atrophy
01/2022 - 09/2020
2Lewy Body Disease (Lewy Body Dementia)
01/2022 - 09/2020
2Chronic Traumatic Encephalopathy
01/2020 - 01/2019
2Pick Disease of the Brain (Pick's Disease)
01/2020 - 01/2017
2Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)
01/2020 - 01/2020
2Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
01/2020 - 11/2019
2Conversion Disorder (Astasia Abasia)
01/2011 - 03/2002
1Cognitive Dysfunction
01/2021
1Parkinsonian Disorders (Parkinsonism)
01/2020
1Corticobasal Degeneration
01/2020
1Peripheral Nervous System Diseases (PNS Diseases)
01/2019
1Fatal Familial Insomnia
01/2017
1Nervous System Diseases (Neurological Disorders)
01/2017
1Neuroinflammatory Diseases
01/2016
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
01/2016
1Motor Neuron Disease (Primary Lateral Sclerosis)
01/2013
1Amyloidosis
05/2008

Drug/Important Bio-Agent (IBA)

58PrionsIBA
01/2022 - 05/2005
47Prion ProteinsIBA
01/2021 - 09/2002
20PrPSc ProteinsIBA
01/2017 - 03/2002
16Peptide Hydrolases (Proteases)FDA Link
11/2017 - 03/2002
15Proteins (Proteins, Gene)FDA Link
01/2022 - 07/2003
13Amyloid (Amyloid Fibrils)IBA
08/2019 - 06/2005
11Biomarkers (Surrogate Marker)IBA
01/2021 - 08/2012
8SynucleinsIBA
01/2022 - 01/2018
7Protein Isoforms (Isoforms)IBA
01/2019 - 03/2002
5PrPC ProteinsIBA
04/2012 - 03/2002
3Protein AggregatesIBA
01/2022 - 01/2003
3alpha-SynucleinIBA
11/2021 - 01/2021
3Codon (Codons)IBA
08/2019 - 01/2017
3Pentosan Sulfuric Polyester (Pentosan Polysulfate)FDA Link
04/2012 - 01/2006
3PorphyrinsIBA
12/2007 - 01/2006
2Biological ProductsIBA
01/2021 - 10/2015
2Pharmaceutical PreparationsIBA
01/2019 - 11/2016
2Hazardous Substances (Hazardous Materials)IBA
11/2018 - 11/2016
2Lysine (L-Lysine)FDA Link
09/2017 - 08/2015
2Polysaccharides (Glycans)IBA
05/2011 - 01/2010
2Detergents (Detergent)IBA
05/2010 - 03/2006
1ferric oxide (iron oxide)IBA
01/2021
1brazilinIBA
01/2021
1Amyloidogenic ProteinsIBA
01/2020
1thioflavin TIBA
01/2020
1Glial Fibrillary Acidic ProteinIBA
08/2019
1Phosphopyruvate Hydratase (Enolase)IBA
08/2019
1Messenger RNA (mRNA)IBA
01/2019
1Antisense OligonucleotidesIBA
01/2019
1tau Proteins (tau Protein)IBA
01/2017
1Sodium ChlorideFDA LinkGeneric
03/2016
1Dihydrotachysterol (AT 10)IBA
03/2016
1AntibodiesIBA
01/2016
1EpitopesIBA
01/2016
1ImmunosorbentsIBA
01/2016
1Peptides (Polypeptides)IBA
01/2016
1EnzymesIBA
01/2016
1Proline (L-Proline)FDA Link
08/2015
1Heparin (Liquaemin)FDA LinkGeneric
06/2014
1Pathogen-Associated Molecular Pattern MoleculesIBA
04/2014
1PACAP-related peptideIBA
01/2014
1Tetracycline (Achromycin)FDA LinkGeneric
04/2012
1Tannic AcidFDA Link
04/2012
1Complement System Proteins (Complement)IBA
02/2012
1PhosphatidylserinesIBA
02/2012
1Annexin A5IBA
02/2012
1Carrier Proteins (Binding Protein)IBA
02/2012
1BuffersIBA
05/2010
1SaltsIBA
05/2010
1Carisoprodol (Soma)FDA LinkGeneric
04/2010
1HydrogenIBA
09/2009
1DeuteriumIBA
09/2009
1TetrapyrrolesIBA
11/2007
1Basic Amino Acids (Basic Amino Acid)IBA
08/2006
1Glutamine (L-Glutamine)FDA Link
08/2006
1OligonucleotidesIBA
08/2006
1ChloridesIBA
01/2006
1Doxycycline (Periostat)FDA LinkGeneric
01/2006
1IndiumIBA
01/2006
1Indicators and Reagents (Reagents)IBA
01/2006
1tetraphenylporphine sulfonate (TPPS)IBA
01/2006

Therapy/Procedure

7Therapeutics
01/2019 - 05/2003
1Injections
01/2019
1Transplantation
11/2018
1Blood Transfusion (Blood Transfusions)
01/2011