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Narikazu Boku Selected Research

irinotecan (Camptosar)

10/2015Phase I study of TAS-102 and irinotecan combination therapy in Japanese patients with advanced colorectal cancer.
1/2015A phase 3 non-inferiority study of 5-FU/l-leucovorin/irinotecan (FOLFIRI) versus irinotecan/S-1 (IRIS) as second-line chemotherapy for metastatic colorectal cancer: updated results of the FIRIS study.
12/2013Randomized, open-label, phase III study comparing irinotecan with paclitaxel in patients with advanced gastric cancer without severe peritoneal metastasis after failure of prior combination chemotherapy using fluoropyrimidine plus platinum: WJOG 4007 trial.
10/2013Randomized Phase III study of 5-fluorouracil continuous infusion vs. sequential methotrexate and 5-fluorouracil therapy in far advanced gastric cancer with peritoneal metastasis (JCOG0106).
8/2013A phase I study of intravenous aflibercept with FOLFIRI in Japanese patients with previously treated metastatic colorectal cancer.
5/2013Risk factors for severe adverse effects and treatment-related deaths in Japanese patients treated with irinotecan-based chemotherapy: a postmarketing survey.
12/2012Bevacizumab in combination with irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI) in patients with metastatic colorectal cancer who were previously treated with oxaliplatin-containing regimens: a multicenter observational cohort study (TCTG 2nd-BV study).
10/2012Phase I/II study of radiologic hepatic arterial infusion of fluorouracil plus systemic irinotecan for unresectable hepatic metastases from colorectal cancer: Japan Clinical Oncology Group Trial 0208-DI.
8/2012Modified FOLFOX-6 therapy for heavily pretreated advanced gastric cancer refractory to fluorouracil, irinotecan, cisplatin and taxanes: a retrospective study.
12/2011Past and present achievements, and future direction of the Gastrointestinal Oncology Study Group (GIOSG), a Division of Japan Clinical Oncology Group (JCOG).
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Narikazu Boku Research Topics

Disease

50Stomach Neoplasms (Stomach Cancer)
11/2015 - 03/2002
37Neoplasms (Cancer)
07/2015 - 01/2002
31Colorectal Neoplasms (Colorectal Cancer)
10/2015 - 01/2003
19Neoplasm Metastasis (Metastasis)
11/2015 - 07/2003
14Pancreatic Neoplasms (Pancreatic Cancer)
07/2015 - 01/2006
9Disease Progression
01/2014 - 07/2007
8Adenocarcinoma
11/2015 - 10/2008
8Anorexia
05/2015 - 04/2008
7Neutropenia
03/2015 - 04/2008
7Diarrhea
03/2015 - 08/2009
7Esophageal Neoplasms (Esophageal Cancer)
08/2011 - 01/2002
6Nausea
05/2015 - 04/2008
6Hemorrhage
02/2015 - 04/2002
5Squamous Cell Carcinoma (Epidermoid Carcinoma)
06/2015 - 10/2002
5Fatigue
05/2015 - 04/2008
5Biliary Tract Neoplasms (Biliary Tract Cancer)
09/2013 - 11/2007
4Thrombocytopenia (Thrombopenia)
10/2014 - 11/2009
4Breast Neoplasms (Breast Cancer)
01/2014 - 12/2009
4Ascites
12/2010 - 10/2008
3Carcinoma (Carcinomatosis)
10/2015 - 10/2009
3Hypertension (High Blood Pressure)
05/2015 - 12/2012
3Colonic Neoplasms (Colon Cancer)
12/2014 - 11/2012
3Anemia
10/2014 - 04/2010
3Small Cell Carcinoma
10/2009 - 12/2005
2Dysphonia (Spastic Dysphonia)
05/2015 - 08/2013
2Drug Toxicity (Drug Safety)
03/2015 - 05/2013
2Infection
04/2014 - 05/2013
2Proteinuria
08/2013 - 11/2009
2Pleural Effusion (Pleural Effusions)
05/2013 - 10/2008
1Hematoma
02/2015
1Rupture
12/2014
1Varicose Veins (Varicose Vein)
12/2014
1Portal Hypertension
12/2014
1Lymphangitis
09/2014
1Neuroendocrine Carcinoma
09/2014
1Hepatocellular Carcinoma (Hepatoma)
04/2014
1Exanthema (Rash)
08/2013

Drug/Important Bio-Agent (IBA)

43Fluorouracil (Carac)FDA LinkGeneric
10/2015 - 01/2002
30Cisplatin (Platino)FDA LinkGeneric
11/2015 - 01/2002
26irinotecan (Camptosar)FDA LinkGeneric
10/2015 - 01/2003
17oxaliplatin (Eloxatin)FDA LinkGeneric
10/2015 - 04/2006
15gemcitabineFDA Link
07/2015 - 12/2005
13Leucovorin (Folinic Acid)FDA Link
09/2015 - 04/2006
9Biological Markers (Surrogate Marker)IBA
04/2014 - 01/2002
8bevacizumabFDA Link
09/2015 - 08/2007
8Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
02/2012 - 01/2002
7docetaxel (Taxotere)FDA Link
06/2015 - 01/2006
7PlatinumIBA
12/2013 - 05/2006
6trastuzumab (Herceptin)FDA Link
11/2015 - 02/2010
6Paclitaxel (Taxol)FDA LinkGeneric
12/2013 - 12/2005
6capecitabine (Xeloda)FDA Link
04/2013 - 12/2008
6TegafurIBA
09/2010 - 01/2003
4cetuximab (Erbitux)FDA Link
03/2010 - 05/2008
3sunitinib (Sutent)FDA Link
04/2014 - 12/2011
3Epidermal Growth Factor Receptor (EGF Receptor)IBA
01/2014 - 01/2002
3Methotrexate (Mexate)FDA LinkGeneric
10/2013 - 06/2008
3Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
08/2013 - 12/2011
3gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA
02/2013 - 04/2010
3Epidermal Growth Factor (EGF)IBA
12/2012 - 04/2012
3TaxoidsIBA
08/2012 - 01/2006
34- ((4- Fluoro- 2- methyl- 1H- indol- 5- yl)oxy)- 6- methoxy- 7- (3- (pyrrolidin- 1- yl)propoxy)quinazoline (AZD2171)IBA
08/2012 - 11/2009
3UracilIBA
07/2010 - 01/2003
3Thymidylate SynthaseIBA
12/2005 - 01/2002
2Phosphotransferases (Kinase)IBA
08/2015 - 12/2012
2Alanine Transaminase (SGPT)IBA
10/2014 - 04/2013
2panitumumab (Vectibix)FDA Link
03/2014 - 05/2008
2Hemoglobins (Hemoglobin)IBA
04/2013 - 04/2008
2Aspartate Aminotransferases (Aspartate Transaminase)IBA
04/2013 - 02/2013
2squamous cell of head and neck CarcinomaIBA
12/2011 - 10/2002
2Mitomycin (Mitomycin-C)FDA LinkGeneric
08/2011 - 01/2003
2XELOXIBA
04/2011 - 10/2010
2erlotinib (CP 358,774)FDA Link
02/2011 - 03/2010
2potassium oxonateIBA
09/2010 - 11/2009
2L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
12/2009 - 10/2008
2Formaldehyde (Formol)FDA Link
01/2006 - 01/2002
2Glutathione S-Transferase piIBA
12/2005 - 01/2002
2Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)IBA
01/2004 - 01/2002
1TAS 102IBA
10/2015
1tyrosine receptor (receptor, tyrosine)IBA
08/2015
1Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
07/2015
1Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
05/2015
1axitinib (AG 013736)IBA
05/2015
1Polymethyl Methacrylate (Sol)IBA
03/2015
1Adenosine Triphosphate (ATP)IBA
04/2014
1ARQ 197IBA
04/2014
1pertuzumabIBA
01/2014
1lapatinib (GW572016)FDA Link
01/2014
1nimotuzumabIBA
11/2013
1afliberceptIBA
08/2013
1tivozanibIBA
08/2013

Therapy/Procedure

73Drug Therapy (Chemotherapy)
11/2015 - 03/2002
7Combination Drug Therapy (Combination Chemotherapy)
12/2013 - 01/2006
7Radiotherapy
05/2013 - 04/2003
5Adjuvant Chemotherapy
11/2015 - 03/2008
5Gastrectomy
01/2013 - 11/2004
2Aftercare (After-Treatment)
08/2015 - 01/2014
2Palliative Care (Palliative Medicine)
11/2012 - 01/2011
2Blood Transfusion (Blood Transfusions)
01/2011 - 04/2002
2Oral Administration
11/2009 - 10/2006
1Bed Rest (Bedrest)
02/2015