Transforming Growth Factor beta

A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

Also Known As:

TGF-beta; Milk Growth Factor; TGFbeta; Bone Derived Transforming Growth Factor; Factor, Milk Growth; Growth Factor, Milk; Bone-Derived Transforming Growth Factor; Platelet Transforming Growth Factor

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Intercellular Signaling Peptides and Proteins: 12097
    - Cytokines: 54678
      - Transforming Growth Factor beta: 11179
    - Transforming Growth Factors: 4743
      - Transforming Growth Factor beta: 11179
    - TGF-beta Superfamily Proteins: 1
      - Transforming Growth Factors: 4743
        Transforming Growth Factor beta: 11179
- Peptides: 22950
  - Intercellular Signaling Peptides and Proteins: 12097
    - Cytokines: 54678
      - Transforming Growth Factor beta: 11179
    - Transforming Growth Factors: 4743
      - Transforming Growth Factor beta: 11179
    - TGF-beta Superfamily Proteins: 1
      - Transforming Growth Factors: 4743
        Transforming Growth Factor beta: 11179
Biological Factors: 1315
- Intercellular Signaling Peptides and Proteins: 12097
  - Cytokines: 54678
    - Transforming Growth Factor beta: 11179
  - Transforming Growth Factors: 4743
    - Transforming Growth Factor beta: 11179
  - TGF-beta Superfamily Proteins: 1
    - Transforming Growth Factors: 4743
      - Transforming Growth Factor beta: 11179

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Disease

Drug/Important Bio-Agent (IBA)