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Leonard Amaral Selected Research

phenothiazine

6/2015Reversal of ABCB1-related Multidrug Resistance of Colonic Adenocarcinoma Cells by Phenothiazines.
4/2014Multidrug resistance reversing activity of newly developed phenothiazines on P-glycoprotein (ABCB1)-related resistance of mouse T-lymphoma cells.
3/2014Mechanisms by which thioridazine in combination with antibiotics cures extensively drug-resistant infections of pulmonary tuberculosis.
12/2013The mechanism by which the phenothiazine thioridazine contributes to cure problematic drug-resistant forms of pulmonary tuberculosis: recent patents for "new use".
5/2012Why thioridazine in combination with antibiotics cures extensively drug-resistant Mycobacterium tuberculosis infections.
12/2011Thioridazine induces apoptosis of multidrug-resistant mouse lymphoma cells transfected with the human ABCB1 and inhibits the expression of P-glycoprotein.
5/2011New patentable use of an old neuroleptic compound thioridazine to combat tuberculosis: a gene regulation perspective.
7/2010Phenothiazines, bacterial efflux pumps and targeting the macrophage for enhanced killing of intracellular XDRTB.
2/2010Thioridazine protects the mouse from a virulent infection by Salmonella enterica serovar Typhimurium 74.
3/2003Clinical concentrations of thioridazine kill intracellular multidrug-resistant Mycobacterium tuberculosis.

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Leonard Amaral Research Topics

Disease

24Infection
03/2014 - 05/2003
16Tuberculosis (Tuberculoses)
01/2015 - 09/2002
13Neoplasms (Cancer)
01/2015 - 05/2003
11Extensively Drug-Resistant Tuberculosis
03/2014 - 04/2008
9Lymphoma (Lymphomas)
01/2015 - 06/2009
9Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis)
12/2013 - 09/2005
5Acquired Immunodeficiency Syndrome (AIDS)
03/2012 - 07/2005
4Pulmonary Tuberculosis
03/2014 - 06/2010
2Breast Neoplasms (Breast Cancer)
05/2013 - 09/2009
2Bacterial Infections (Bacterial Infection)
05/2009 - 09/2003
1Adenocarcinoma
06/2015
1Prostatic Neoplasms (Prostate Cancer)
11/2013
1Salmonella Infections (Salmonellosis)
02/2010
1Communicable Diseases (Infectious Diseases)
05/2009
1Sudden Death
07/2006
1Cross Infection (Nosocomial Infection)
11/2004
1Urinary Tract Infections (Urinary Tract Infection)
09/2003
1T-Cell Lymphoma (Lymphoma, T Cell)
05/2003
1Staphylococcal Infections
09/2002

Drug/Important Bio-Agent (IBA)

20Thioridazine (Mellaril)FDA LinkGeneric
03/2014 - 11/2004
13Anti-Bacterial Agents (Antibiotics)IBA
03/2014 - 09/2002
10phenothiazineIBA
06/2015 - 03/2003
7P-GlycoproteinIBA
04/2014 - 06/2009
6PhenothiazinesIBA
06/2015 - 09/2003
4Ethidium (Ethidium Bromide)IBA
04/2014 - 10/2009
4Carbon MonoxideIBA
05/2013 - 07/2005
4Rifampin (Rifampicin)FDA LinkGeneric
01/2012 - 09/2005
3Doxorubicin (Adriamycin)FDA LinkGeneric
01/2015 - 12/2010
3Rhodamine 123IBA
04/2014 - 10/2009
3butyl 3-(1H-tetrazol-5-yl)oxanilate (MTB)IBA
03/2014 - 03/2005
3Isoniazid (Ftivazide)FDA LinkGeneric
06/2012 - 01/2010
3Chlorpromazine (Thorazine)FDA Link
12/2011 - 11/2004
3Verapamil (Calan)FDA LinkGeneric
12/2009 - 05/2003
2EcdysteroidsIBA
01/2015 - 01/2013
2Adenosine Triphosphate (ATP)IBA
11/2013 - 06/2009
21,3- dimethyl- 1,3- bis(4- fluorophenyl)- 1,3- bis(3- (1- (4- butypiperazinyl))propyl)disiloxaneIBA
05/2013 - 05/2009
2ATP-Binding Cassette Transporters (ABC Transporters)IBA
10/2009 - 06/2009
2Reserpine (Serpasil)FDA Link
01/2008 - 09/2002
1Paclitaxel (Taxol)FDA LinkGeneric
01/2015
1Ecdysterone (20 Hydroxyecdysone)IBA
01/2015
1Vincristine (Oncovin)FDA LinkGeneric
01/2015
1Cisplatin (Platino)FDA LinkGeneric
01/2015
1benz(a)anthracene (benzanthracene)IBA
05/2013
11,3- dimethyl- 1,3- p- fluorophenyl- 1,3- (3- morpholinopropyl)- 1,3- disiloxaneIBA
05/2013
11,3- dimethyl- 1,3- (4- fluorophenyl)- 1,3- (3- butyl- (1- piperazinyl)propyl)- 1,3- disiloxaneIBA
05/2013
1disiloxaneIBA
05/2013
19,10-Dimethyl-1,2-benzanthracene (DMBA)IBA
05/2013
1AntigensIBA
05/2013
1Epstein-Barr virus early antigenIBA
05/2013
1DioxolanesIBA
01/2013
1PyrazinamideFDA LinkGeneric
01/2010
1Azithromycin (Zithromax)FDA LinkGeneric
12/2009
1MacrolidesIBA
12/2009
1Clarithromycin (Biaxin)FDA LinkGeneric
12/2009
1DisinfectantsIBA
10/2009
1Serine Proteases (Serine Protease)IBA
09/2009
1ethyl N- allyl- N- (2- methyl- 3- (4- (4- amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonateIBA
09/2009
1FOY 305 (camostat)IBA
09/2009
1EnzymesIBA
05/2009
1Ouabain (G Strophanthin)IBA
01/2008
1Diclofenac (SR 38)FDA LinkGeneric
09/2007
1Tetracycline (Achromycin)FDA LinkGeneric
07/2007
1Tuberculin (PPD)IBA
03/2005
1VancomycinFDA LinkGeneric
11/2004
1InterferonsIBA
08/2004
1Interleukin-4 (Interleukin 4)IBA
08/2004
1InterleukinsIBA
08/2004
1Promethazine (Promet)FDA LinkGeneric
09/2003
1Sepharose (Agarose)IBA
09/2003

Therapy/Procedure

6Drug Therapy (Chemotherapy)
01/2015 - 05/2003
1Heterologous Transplantation (Xenotransplantation)
01/2015
1Chemoprevention
05/2013
1Oral Administration
01/2010
1Therapeutics
04/2008