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Joseph L Alcorn Selected Research

Pseudoachondroplasia

7/2014Pseudoachondroplasia/COMP - translating from the bench to the bedside.
2/2012Chop (Ddit3) is essential for D469del-COMP retention and cell death in chondrocytes in an inducible transgenic mouse model of pseudoachondroplasia.
1/2010RNAi reduces expression and intracellular retention of mutant cartilage oligomeric matrix protein.
4/2009Ribozyme-mediated reduction of wild-type and mutant cartilage oligomeric matrix protein (COMP) mRNA and protein.
1/2007Unique matrix structure in the rough endoplasmic reticulum cisternae of pseudoachondroplasia chondrocytes.
4/2006Expression of mutant cartilage oligomeric matrix protein in human chondrocytes induces the pseudoachondroplasia phenotype.

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Joseph L Alcorn Research Topics

Disease

5Osteochondrodysplasias (Spondyloepiphyseal Dysplasia)
02/2012 - 04/2006
3Infection
10/2009 - 02/2005
2Pneumonia (Pneumonitis)
11/2015 - 01/2011
2Anoxia (Hypoxia)
05/2015 - 11/2013
2Fibrosis (Cirrhosis)
02/2014 - 01/2011
2Inflammation
01/2014 - 01/2011
2Substance-Related Disorders (Drug Abuse)
01/2013 - 07/2012
2Lung Injury
01/2011 - 03/2010
1Necrotizing Enterocolitis
05/2015
1Osteoarthritis
07/2014
1Antisocial Personality Disorder (Antisocial Personality)
01/2013
1Necrosis
02/2012
1Lung Diseases (Lung Disease)
01/2011
1Acute Lung Injury
03/2010
1Body Weight (Weight, Body)
03/2010
1Atherosclerosis
03/2007
1Premature Obstetric Labor (Premature Labor)
01/2007
1Adenocarcinoma
10/2004

Drug/Important Bio-Agent (IBA)

6PseudoachondroplasiaIBA
07/2014 - 04/2006
4cartilage matrix proteinIBA
01/2010 - 04/2006
3Pulmonary Surfactant-Associated Protein A (Surfactant Protein A)IBA
05/2015 - 12/2005
3Glycoproteins (Glycoprotein)IBA
01/2010 - 04/2006
3Messenger RNA (mRNA)IBA
10/2009 - 02/2005
2Bleomycin (Blenoxane)FDA LinkGeneric
02/2014 - 03/2010
2Proteins (Proteins, Gene)IBA
01/2014 - 12/2005
1OzoneIBA
11/2015
1CytokinesIBA
05/2015
1Caspase 3 (Caspase-3)IBA
11/2013
14-aminospiroperidolIBA
01/2013
1tiagabine (Gabitril)FDA Link
07/2012
1Apoptosis Inducing FactorIBA
02/2012
1CaspasesIBA
02/2012
1Adenosine DeaminaseIBA
01/2011
1AdenosineFDA LinkGeneric
01/2011
1Interleukin-6 (Interleukin 6)IBA
01/2011
1CollagenIBA
03/2010
1OxygenIBA
03/2010
1Proteasome Endopeptidase Complex (Proteasome)IBA
10/2009
1PPAR deltaIBA
03/2007
1CCAAT-Enhancer-Binding Protein-betaIBA
03/2007
1NF-kappa B (NF-kB)IBA
01/2007
1ProgesteroneFDA LinkGeneric
01/2007
1Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA
12/2005
1Pulmonary Surfactants (Pulmonary Surfactant)IBA
12/2005
1Nitric Oxide (Nitrogen Monoxide)FDA Link
02/2005
1NitritesIBA
02/2005
1Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
02/2005
1InterferonsIBA
02/2005
1Dexamethasone (Maxidex)FDA LinkGeneric
10/2004

Therapy/Procedure

1Oral Administration
05/2015
1Transplantation (Transplant Recipients)
03/2010