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Donohue Syndrome Summary

Description: Rare autosomal recessive syndrome of extreme insulin resistance due to mutations in the binding domain of INSULIN RECEPTOR. Clinical features include severe intrauterine and postnatal growth restriction, characteristic dysmorphic FACIES; HIRSUTISM; VIRILIZATION; multiple endocrine abnormalities, and early death.

Also Known As: Leprechaunisms; Rabson Mendenhall Syndrome; Syndrome, Donohue; Syndrome, Mendenhall; Syndrome, Rabson-Mendenhall Show All >>

Networked: 164 relevant articles (2 outcomes, 8 trials/studies) for this Disease

Key Drugs and Agents for Donohue Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Insulin (Novolin) : 1 outcome 3 studies in 67 results : FDA 2
  2. Idiopathic hypertrophic subaortic stenosis (IHSS) : 1 outcome in 1 result : IBA
  3. recombinant methionyl human leptin : 1 outcome in 1 result : IBA
  4. Insulin Receptor : 4 studies in 111 results : IBA
  5. Insulin-Like Growth Factor I (IGF-1) : 3 studies in 19 results : IBA
  6. Blood Glucose (Blood Sugar) : 1 study in 1 result : IBA
  7. Glucose (Dextrose) : 18 results : FDA 175 Generic
  8. Phosphotransferases (Kinase) : 7 results : IBA
  9. Nonsense Codon (Nonsense Mutation) : 5 results : IBA
  10. Protein-Tyrosine Kinases (Tyrosine Kinase) : 5 results : IBA
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Diseases Related to Donohue Syndrome

  1. Insulin Resistance
  2. Hyperglycemia
  3. Congenital Generalized Lipodystrophy (Berardinelli-Seip Congenital Lipodystrophy)
  4. Donohue Syndrome
  5. Hypoglycemia (Reactive Hypoglycemia)
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Key Therapies for Donohue Syndrome

Efficacy Chart >>
  1. Subcutaneous Infusions : 1 outcome in 1 result
  2. Lasers (Laser) : 1 result
  3. Anesthesia : 1 result

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